Feasibility Study of Lactobacillus Plantarum 299v Probiotic Supplementation in an Urban Academic Facility among Diverse Pregnant Individuals
(1) Background: Despite iron intake recommendations, over a quarter of pregnant individuals have iron deficiency. ( ®) enhances iron absorption in non-pregnant populations and may have positive effects in pregnancy among those with sufficient iron stores; however, no studies have evaluated the effec...
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| Veröffentlicht in: | Nutrients 2023-02, Vol.15 (4), p.875 |
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| creator | OjiNjideka Hemphill, Nefertiti Pezley, Lacey Steffen, Alana Elam, Gloria Kominiarek, Michelle A Odoms-Young, Angela Kessee, Nicollette Hamm, Alyshia Tussing-Humphreys, Lisa Koenig, Mary Dawn |
| description | (1) Background: Despite iron intake recommendations, over a quarter of pregnant individuals have iron deficiency.
(
®) enhances iron absorption in non-pregnant populations and may have positive effects in pregnancy among those with sufficient iron stores; however, no studies have evaluated the effect of
® on maternal and neonatal iron status among individuals at risk for iron deficiency anemia in pregnancy. Thus, this study aims to assess the feasibility and preliminary efficacy of daily oral
® maternal supplementation among diverse pregnant individuals. (2) Methods: In this double-blind placebo-controlled randomized supplementation feasibility study, participants were randomized to probiotic
® + prenatal vitamin with iron or placebo + prenatal vitamin with iron from 15-20 weeks of gestation through delivery. (3) Results: Of the 20 enrolled and randomized participants, 58% (7/12) from the
® group and 75% (6/8) from the placebo group were retained. Adherence to supplementation was 72% for
®/placebo and 73% for the prenatal vitamin. A slower decline in maternal hematological and iron parameters across pregnancy was observed in the
® group compared to placebo. (4) Conclusions:
® may be a tolerable therapy during pregnancy and has the potential to affect maternal and neonatal hematological and iron status. |
| doi_str_mv | 10.3390/nu15040875 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9966742</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2779630450</sourcerecordid><originalsourceid>FETCH-LOGICAL-c406t-30c4e6dfc6404694aeabd30985b1ea8d070b49c0311eca24d4e12479e53074c93</originalsourceid><addsrcrecordid>eNpdkdFqFDEUhoMottTe-AAS8EaE1TNJJjO5EUrrtoUFC7XXIZOcXVNmkjWZLOw7-NBmaa3VXOQEzsfH-XMIedvAJ84VfA6laUFA37UvyDGDji2kFPzls_cROc35Hg6ng07y1-SIy54rxtkx-bVEk_3gRz_v6e1c3J7GNV0ZO8fBWD-OJdOb0YTZpDJRptSO3qQ4-Dh7S2_LdjvihLU7-xioD9QEepeGep9Z43Cq0PKgOdjNFMOGXvgdpozVgptQvfQ6OL_zrpgxvyGv1rXg6WM9IXfLr9_Prxarb5fX52erhRUg5wUHK1C6tZUChFTCoBkcB9W3Q4OmdzXmIJQF3jRoDRNOYMNEp7Dl0Amr-An58uDdlmFCZ2uAZEa9TX4yaa-j8frfTvA_9CbutFJSdoJVwYdHQYo_C-ZZTz5bHOtHYSxZs64H6KEBWdH3_6H3saRQ41WqU5KDaKFSHx8om2LOCddPwzSgD3vWf_dc4XfPx39C_2yV_wbkmaTr</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2779630450</pqid></control><display><type>article</type><title>Feasibility Study of Lactobacillus Plantarum 299v Probiotic Supplementation in an Urban Academic Facility among Diverse Pregnant Individuals</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>OjiNjideka Hemphill, Nefertiti ; Pezley, Lacey ; Steffen, Alana ; Elam, Gloria ; Kominiarek, Michelle A ; Odoms-Young, Angela ; Kessee, Nicollette ; Hamm, Alyshia ; Tussing-Humphreys, Lisa ; Koenig, Mary Dawn</creator><creatorcontrib>OjiNjideka Hemphill, Nefertiti ; Pezley, Lacey ; Steffen, Alana ; Elam, Gloria ; Kominiarek, Michelle A ; Odoms-Young, Angela ; Kessee, Nicollette ; Hamm, Alyshia ; Tussing-Humphreys, Lisa ; Koenig, Mary Dawn</creatorcontrib><description>(1) Background: Despite iron intake recommendations, over a quarter of pregnant individuals have iron deficiency.
(
®) enhances iron absorption in non-pregnant populations and may have positive effects in pregnancy among those with sufficient iron stores; however, no studies have evaluated the effect of
® on maternal and neonatal iron status among individuals at risk for iron deficiency anemia in pregnancy. Thus, this study aims to assess the feasibility and preliminary efficacy of daily oral
® maternal supplementation among diverse pregnant individuals. (2) Methods: In this double-blind placebo-controlled randomized supplementation feasibility study, participants were randomized to probiotic
® + prenatal vitamin with iron or placebo + prenatal vitamin with iron from 15-20 weeks of gestation through delivery. (3) Results: Of the 20 enrolled and randomized participants, 58% (7/12) from the
® group and 75% (6/8) from the placebo group were retained. Adherence to supplementation was 72% for
®/placebo and 73% for the prenatal vitamin. A slower decline in maternal hematological and iron parameters across pregnancy was observed in the
® group compared to placebo. (4) Conclusions:
® may be a tolerable therapy during pregnancy and has the potential to affect maternal and neonatal hematological and iron status.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu15040875</identifier><identifier>PMID: 36839232</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Anemia ; Blood ; Childbirth & labor ; Coronaviruses ; COVID-19 ; Data collection ; Disease transmission ; Double-Blind Method ; Electronic health records ; Feasibility Studies ; Female ; Hematology ; Humans ; Infant, Newborn ; Iron ; Lactobacilli ; Lactobacillus plantarum ; Medical research ; Neonates ; Nutrient deficiency ; Obstetrics ; Pandemics ; Placebos ; Pregnancy ; Probiotics ; Vitamins ; Womens health</subject><ispartof>Nutrients, 2023-02, Vol.15 (4), p.875</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-30c4e6dfc6404694aeabd30985b1ea8d070b49c0311eca24d4e12479e53074c93</citedby><cites>FETCH-LOGICAL-c406t-30c4e6dfc6404694aeabd30985b1ea8d070b49c0311eca24d4e12479e53074c93</cites><orcidid>0000-0002-2217-1105 ; 0000-0003-3385-8460</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966742/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966742/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36839232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OjiNjideka Hemphill, Nefertiti</creatorcontrib><creatorcontrib>Pezley, Lacey</creatorcontrib><creatorcontrib>Steffen, Alana</creatorcontrib><creatorcontrib>Elam, Gloria</creatorcontrib><creatorcontrib>Kominiarek, Michelle A</creatorcontrib><creatorcontrib>Odoms-Young, Angela</creatorcontrib><creatorcontrib>Kessee, Nicollette</creatorcontrib><creatorcontrib>Hamm, Alyshia</creatorcontrib><creatorcontrib>Tussing-Humphreys, Lisa</creatorcontrib><creatorcontrib>Koenig, Mary Dawn</creatorcontrib><title>Feasibility Study of Lactobacillus Plantarum 299v Probiotic Supplementation in an Urban Academic Facility among Diverse Pregnant Individuals</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>(1) Background: Despite iron intake recommendations, over a quarter of pregnant individuals have iron deficiency.
(
®) enhances iron absorption in non-pregnant populations and may have positive effects in pregnancy among those with sufficient iron stores; however, no studies have evaluated the effect of
® on maternal and neonatal iron status among individuals at risk for iron deficiency anemia in pregnancy. Thus, this study aims to assess the feasibility and preliminary efficacy of daily oral
® maternal supplementation among diverse pregnant individuals. (2) Methods: In this double-blind placebo-controlled randomized supplementation feasibility study, participants were randomized to probiotic
® + prenatal vitamin with iron or placebo + prenatal vitamin with iron from 15-20 weeks of gestation through delivery. (3) Results: Of the 20 enrolled and randomized participants, 58% (7/12) from the
® group and 75% (6/8) from the placebo group were retained. Adherence to supplementation was 72% for
®/placebo and 73% for the prenatal vitamin. A slower decline in maternal hematological and iron parameters across pregnancy was observed in the
® group compared to placebo. (4) Conclusions:
® may be a tolerable therapy during pregnancy and has the potential to affect maternal and neonatal hematological and iron status.</description><subject>Anemia</subject><subject>Blood</subject><subject>Childbirth & labor</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Data collection</subject><subject>Disease transmission</subject><subject>Double-Blind Method</subject><subject>Electronic health records</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Iron</subject><subject>Lactobacilli</subject><subject>Lactobacillus plantarum</subject><subject>Medical research</subject><subject>Neonates</subject><subject>Nutrient deficiency</subject><subject>Obstetrics</subject><subject>Pandemics</subject><subject>Placebos</subject><subject>Pregnancy</subject><subject>Probiotics</subject><subject>Vitamins</subject><subject>Womens health</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkdFqFDEUhoMottTe-AAS8EaE1TNJJjO5EUrrtoUFC7XXIZOcXVNmkjWZLOw7-NBmaa3VXOQEzsfH-XMIedvAJ84VfA6laUFA37UvyDGDji2kFPzls_cROc35Hg6ng07y1-SIy54rxtkx-bVEk_3gRz_v6e1c3J7GNV0ZO8fBWD-OJdOb0YTZpDJRptSO3qQ4-Dh7S2_LdjvihLU7-xioD9QEepeGep9Z43Cq0PKgOdjNFMOGXvgdpozVgptQvfQ6OL_zrpgxvyGv1rXg6WM9IXfLr9_Prxarb5fX52erhRUg5wUHK1C6tZUChFTCoBkcB9W3Q4OmdzXmIJQF3jRoDRNOYMNEp7Dl0Amr-An58uDdlmFCZ2uAZEa9TX4yaa-j8frfTvA_9CbutFJSdoJVwYdHQYo_C-ZZTz5bHOtHYSxZs64H6KEBWdH3_6H3saRQ41WqU5KDaKFSHx8om2LOCddPwzSgD3vWf_dc4XfPx39C_2yV_wbkmaTr</recordid><startdate>20230209</startdate><enddate>20230209</enddate><creator>OjiNjideka Hemphill, Nefertiti</creator><creator>Pezley, Lacey</creator><creator>Steffen, Alana</creator><creator>Elam, Gloria</creator><creator>Kominiarek, Michelle A</creator><creator>Odoms-Young, Angela</creator><creator>Kessee, Nicollette</creator><creator>Hamm, Alyshia</creator><creator>Tussing-Humphreys, Lisa</creator><creator>Koenig, Mary Dawn</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2217-1105</orcidid><orcidid>https://orcid.org/0000-0003-3385-8460</orcidid></search><sort><creationdate>20230209</creationdate><title>Feasibility Study of Lactobacillus Plantarum 299v Probiotic Supplementation in an Urban Academic Facility among Diverse Pregnant Individuals</title><author>OjiNjideka Hemphill, Nefertiti ; Pezley, Lacey ; Steffen, Alana ; Elam, Gloria ; Kominiarek, Michelle A ; Odoms-Young, Angela ; Kessee, Nicollette ; Hamm, Alyshia ; Tussing-Humphreys, Lisa ; Koenig, Mary Dawn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-30c4e6dfc6404694aeabd30985b1ea8d070b49c0311eca24d4e12479e53074c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anemia</topic><topic>Blood</topic><topic>Childbirth & labor</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Data collection</topic><topic>Disease transmission</topic><topic>Double-Blind Method</topic><topic>Electronic health records</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Iron</topic><topic>Lactobacilli</topic><topic>Lactobacillus plantarum</topic><topic>Medical research</topic><topic>Neonates</topic><topic>Nutrient deficiency</topic><topic>Obstetrics</topic><topic>Pandemics</topic><topic>Placebos</topic><topic>Pregnancy</topic><topic>Probiotics</topic><topic>Vitamins</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OjiNjideka Hemphill, Nefertiti</creatorcontrib><creatorcontrib>Pezley, Lacey</creatorcontrib><creatorcontrib>Steffen, Alana</creatorcontrib><creatorcontrib>Elam, Gloria</creatorcontrib><creatorcontrib>Kominiarek, Michelle A</creatorcontrib><creatorcontrib>Odoms-Young, Angela</creatorcontrib><creatorcontrib>Kessee, Nicollette</creatorcontrib><creatorcontrib>Hamm, Alyshia</creatorcontrib><creatorcontrib>Tussing-Humphreys, Lisa</creatorcontrib><creatorcontrib>Koenig, Mary Dawn</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OjiNjideka Hemphill, Nefertiti</au><au>Pezley, Lacey</au><au>Steffen, Alana</au><au>Elam, Gloria</au><au>Kominiarek, Michelle A</au><au>Odoms-Young, Angela</au><au>Kessee, Nicollette</au><au>Hamm, Alyshia</au><au>Tussing-Humphreys, Lisa</au><au>Koenig, Mary Dawn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feasibility Study of Lactobacillus Plantarum 299v Probiotic Supplementation in an Urban Academic Facility among Diverse Pregnant Individuals</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2023-02-09</date><risdate>2023</risdate><volume>15</volume><issue>4</issue><spage>875</spage><pages>875-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>(1) Background: Despite iron intake recommendations, over a quarter of pregnant individuals have iron deficiency.
(
®) enhances iron absorption in non-pregnant populations and may have positive effects in pregnancy among those with sufficient iron stores; however, no studies have evaluated the effect of
® on maternal and neonatal iron status among individuals at risk for iron deficiency anemia in pregnancy. Thus, this study aims to assess the feasibility and preliminary efficacy of daily oral
® maternal supplementation among diverse pregnant individuals. (2) Methods: In this double-blind placebo-controlled randomized supplementation feasibility study, participants were randomized to probiotic
® + prenatal vitamin with iron or placebo + prenatal vitamin with iron from 15-20 weeks of gestation through delivery. (3) Results: Of the 20 enrolled and randomized participants, 58% (7/12) from the
® group and 75% (6/8) from the placebo group were retained. Adherence to supplementation was 72% for
®/placebo and 73% for the prenatal vitamin. A slower decline in maternal hematological and iron parameters across pregnancy was observed in the
® group compared to placebo. (4) Conclusions:
® may be a tolerable therapy during pregnancy and has the potential to affect maternal and neonatal hematological and iron status.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36839232</pmid><doi>10.3390/nu15040875</doi><orcidid>https://orcid.org/0000-0002-2217-1105</orcidid><orcidid>https://orcid.org/0000-0003-3385-8460</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2023-02, Vol.15 (4), p.875 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Anemia Blood Childbirth & labor Coronaviruses COVID-19 Data collection Disease transmission Double-Blind Method Electronic health records Feasibility Studies Female Hematology Humans Infant, Newborn Iron Lactobacilli Lactobacillus plantarum Medical research Neonates Nutrient deficiency Obstetrics Pandemics Placebos Pregnancy Probiotics Vitamins Womens health |
| title | Feasibility Study of Lactobacillus Plantarum 299v Probiotic Supplementation in an Urban Academic Facility among Diverse Pregnant Individuals |
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