Rheological Properties of Non-Adhesive Embolizing Compounds-The Key to Fine-Tuning Embolization Process-Modeling in Endovascular Surgery
The study of polymers' rheological properties is of paramount importance both for the problems of their industrial production as well as for their practical application. Two polymers used for embolization of arteriovenous malformations (AVMs) are studied in this work: Onyx-18 and Squid-12 . Vis...
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| Veröffentlicht in: | Polymers 2023-02, Vol.15 (4), p.1060 |
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| creator | Kuianova, Iuliia Chupakhin, Alexander Besov, Alexey Gorbatykh, Anton Kislitsin, Dmitry Orlov, Kirill Parshin, Daniil |
| description | The study of polymers' rheological properties is of paramount importance both for the problems of their industrial production as well as for their practical application. Two polymers used for embolization of arteriovenous malformations (AVMs) are studied in this work: Onyx-18
and Squid-12
. Viscosity curve tests and computational fluid dynamics (CFD) were used to uncover viscosity law as a function of shear rate as well as behavior of the polymers in catheter or pathological tissue models. The property of thermal activation of viscosity was demonstrated, namely, the law of dependence of viscosity on temperature in the range from 20 °C to 37 °C was established. A zone of viscosity nonmonotonicity was identified, and a physical interpretation of the dependence of the embolic polymers' viscosity on the shear rate was given on the basis of Cisco's model. The obtained empirical constants will be useful for researchers based on the CFD of AVMs. A description of the process of temperature activation of the embolic polymers' viscosity is important for understanding the mechanics of the embolization process by practicing surgeons as well as for producing new prospective embolic agents. |
| doi_str_mv | 10.3390/polym15041060 |
| format | Article |
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and Squid-12
. Viscosity curve tests and computational fluid dynamics (CFD) were used to uncover viscosity law as a function of shear rate as well as behavior of the polymers in catheter or pathological tissue models. The property of thermal activation of viscosity was demonstrated, namely, the law of dependence of viscosity on temperature in the range from 20 °C to 37 °C was established. A zone of viscosity nonmonotonicity was identified, and a physical interpretation of the dependence of the embolic polymers' viscosity on the shear rate was given on the basis of Cisco's model. The obtained empirical constants will be useful for researchers based on the CFD of AVMs. A description of the process of temperature activation of the embolic polymers' viscosity is important for understanding the mechanics of the embolization process by practicing surgeons as well as for producing new prospective embolic agents.</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym15041060</identifier><identifier>PMID: 36850343</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adhesives ; Alcohol ; Analysis ; Computational fluid dynamics ; Embolization ; Fistula ; Iodine ; Laboratories ; Mathematical models ; Polymers ; Rheological properties ; Rheology ; Shear rate ; Software ; Surgery ; Temperature ; Temperature dependence ; Tumors ; Viscosity</subject><ispartof>Polymers, 2023-02, Vol.15 (4), p.1060</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-87aae1e5dda86c664cb773f0d3fb0d46d6809e732a9b58310d2ff954fe946d383</citedby><cites>FETCH-LOGICAL-c482t-87aae1e5dda86c664cb773f0d3fb0d46d6809e732a9b58310d2ff954fe946d383</cites><orcidid>0000-0003-0359-648X ; 0000-0002-2496-3042</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966492/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966492/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36850343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuianova, Iuliia</creatorcontrib><creatorcontrib>Chupakhin, Alexander</creatorcontrib><creatorcontrib>Besov, Alexey</creatorcontrib><creatorcontrib>Gorbatykh, Anton</creatorcontrib><creatorcontrib>Kislitsin, Dmitry</creatorcontrib><creatorcontrib>Orlov, Kirill</creatorcontrib><creatorcontrib>Parshin, Daniil</creatorcontrib><title>Rheological Properties of Non-Adhesive Embolizing Compounds-The Key to Fine-Tuning Embolization Process-Modeling in Endovascular Surgery</title><title>Polymers</title><addtitle>Polymers (Basel)</addtitle><description>The study of polymers' rheological properties is of paramount importance both for the problems of their industrial production as well as for their practical application. Two polymers used for embolization of arteriovenous malformations (AVMs) are studied in this work: Onyx-18
and Squid-12
. Viscosity curve tests and computational fluid dynamics (CFD) were used to uncover viscosity law as a function of shear rate as well as behavior of the polymers in catheter or pathological tissue models. The property of thermal activation of viscosity was demonstrated, namely, the law of dependence of viscosity on temperature in the range from 20 °C to 37 °C was established. A zone of viscosity nonmonotonicity was identified, and a physical interpretation of the dependence of the embolic polymers' viscosity on the shear rate was given on the basis of Cisco's model. The obtained empirical constants will be useful for researchers based on the CFD of AVMs. A description of the process of temperature activation of the embolic polymers' viscosity is important for understanding the mechanics of the embolization process by practicing surgeons as well as for producing new prospective embolic agents.</description><subject>Adhesives</subject><subject>Alcohol</subject><subject>Analysis</subject><subject>Computational fluid dynamics</subject><subject>Embolization</subject><subject>Fistula</subject><subject>Iodine</subject><subject>Laboratories</subject><subject>Mathematical models</subject><subject>Polymers</subject><subject>Rheological properties</subject><subject>Rheology</subject><subject>Shear rate</subject><subject>Software</subject><subject>Surgery</subject><subject>Temperature</subject><subject>Temperature dependence</subject><subject>Tumors</subject><subject>Viscosity</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkk1v1DAQhiMEolXpkSuKxIVLihM7dnJBWq22pWr5ECxny2tPdl05nsVOVlp-AT8bR12qXYR98MjzzPtq7Mmy1yW5orQl77fo9n1ZE1YSTp5l5xURtGCUk-dH8Vl2GeMDSYvVnJfiZXZGeVMTyuh59vvbBtDh2mrl8q8BtxAGCzHHLv-MvpiZDUS7g3zRr9DZX9av8zn2Wxy9icVyA_kd7PMB82vroViOfgIOrBos-klTQ4zFJzTgpqz1-cIb3KmoR6dC_n0Mawj7V9mLTrkIl4fzIvtxvVjOPxb3X25u57P7QrOmGopGKAUl1MaohmvOmV4JQTtiaLcihnHDG9KCoJVqV3VDS2Kqrmtr1kGbkrShF9mHR93tuOrBaPBDUE5ug-1V2EtUVp5mvN3INe5k2ya3tkoC7w4CAX-OEAfZ26jBOeUBxygr0RDBWfqThL79B33AMfjUXqJEy6moqyNqrRxI6ztMvnoSlTPBKGWVqCbbq_9QaRvorUYPnU33JwXFY4EOGGOA7qnHkshpeuTJ9CT-zfHDPNF_Z4X-ARDxwfs</recordid><startdate>20230220</startdate><enddate>20230220</enddate><creator>Kuianova, Iuliia</creator><creator>Chupakhin, Alexander</creator><creator>Besov, Alexey</creator><creator>Gorbatykh, Anton</creator><creator>Kislitsin, Dmitry</creator><creator>Orlov, Kirill</creator><creator>Parshin, Daniil</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0359-648X</orcidid><orcidid>https://orcid.org/0000-0002-2496-3042</orcidid></search><sort><creationdate>20230220</creationdate><title>Rheological Properties of Non-Adhesive Embolizing Compounds-The Key to Fine-Tuning Embolization Process-Modeling in Endovascular Surgery</title><author>Kuianova, Iuliia ; Chupakhin, Alexander ; Besov, Alexey ; Gorbatykh, Anton ; Kislitsin, Dmitry ; Orlov, Kirill ; Parshin, Daniil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-87aae1e5dda86c664cb773f0d3fb0d46d6809e732a9b58310d2ff954fe946d383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adhesives</topic><topic>Alcohol</topic><topic>Analysis</topic><topic>Computational fluid dynamics</topic><topic>Embolization</topic><topic>Fistula</topic><topic>Iodine</topic><topic>Laboratories</topic><topic>Mathematical models</topic><topic>Polymers</topic><topic>Rheological properties</topic><topic>Rheology</topic><topic>Shear rate</topic><topic>Software</topic><topic>Surgery</topic><topic>Temperature</topic><topic>Temperature dependence</topic><topic>Tumors</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuianova, Iuliia</creatorcontrib><creatorcontrib>Chupakhin, Alexander</creatorcontrib><creatorcontrib>Besov, Alexey</creatorcontrib><creatorcontrib>Gorbatykh, Anton</creatorcontrib><creatorcontrib>Kislitsin, Dmitry</creatorcontrib><creatorcontrib>Orlov, Kirill</creatorcontrib><creatorcontrib>Parshin, Daniil</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>https://resources.nclive.org/materials</collection><collection>Materials science collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuianova, Iuliia</au><au>Chupakhin, Alexander</au><au>Besov, Alexey</au><au>Gorbatykh, Anton</au><au>Kislitsin, Dmitry</au><au>Orlov, Kirill</au><au>Parshin, Daniil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rheological Properties of Non-Adhesive Embolizing Compounds-The Key to Fine-Tuning Embolization Process-Modeling in Endovascular Surgery</atitle><jtitle>Polymers</jtitle><addtitle>Polymers (Basel)</addtitle><date>2023-02-20</date><risdate>2023</risdate><volume>15</volume><issue>4</issue><spage>1060</spage><pages>1060-</pages><issn>2073-4360</issn><eissn>2073-4360</eissn><abstract>The study of polymers' rheological properties is of paramount importance both for the problems of their industrial production as well as for their practical application. Two polymers used for embolization of arteriovenous malformations (AVMs) are studied in this work: Onyx-18
and Squid-12
. Viscosity curve tests and computational fluid dynamics (CFD) were used to uncover viscosity law as a function of shear rate as well as behavior of the polymers in catheter or pathological tissue models. The property of thermal activation of viscosity was demonstrated, namely, the law of dependence of viscosity on temperature in the range from 20 °C to 37 °C was established. A zone of viscosity nonmonotonicity was identified, and a physical interpretation of the dependence of the embolic polymers' viscosity on the shear rate was given on the basis of Cisco's model. The obtained empirical constants will be useful for researchers based on the CFD of AVMs. A description of the process of temperature activation of the embolic polymers' viscosity is important for understanding the mechanics of the embolization process by practicing surgeons as well as for producing new prospective embolic agents.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36850343</pmid><doi>10.3390/polym15041060</doi><orcidid>https://orcid.org/0000-0003-0359-648X</orcidid><orcidid>https://orcid.org/0000-0002-2496-3042</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Polymers, 2023-02, Vol.15 (4), p.1060 |
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| subjects | Adhesives Alcohol Analysis Computational fluid dynamics Embolization Fistula Iodine Laboratories Mathematical models Polymers Rheological properties Rheology Shear rate Software Surgery Temperature Temperature dependence Tumors Viscosity |
| title | Rheological Properties of Non-Adhesive Embolizing Compounds-The Key to Fine-Tuning Embolization Process-Modeling in Endovascular Surgery |
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