Hopeless Neuroma-The Neurotized Free Flap Tissue Augmentation as Salvage Therapy-A Concept and Clinical Demonstration
Therapy-resistant neuroma pain is a devastating condition for patients and surgeons. Although various methods are described to surgically deal with neuromas, some discontinuity and stump neuroma therapies have anatomical limitations. It is widely known that a neurotizable target for axon ingrowth is...
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Veröffentlicht in: | Journal of personalized medicine 2023-02, Vol.13 (2), p.313 |
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creator | Aman, Martin Glaser, Julia J Boecker, Arne H Thielen, Mirjam Eisa, Amr Bigdeli, Amir K Gazyakan, Emre Kneser, Ulrich Harhaus, Leila |
description | Therapy-resistant neuroma pain is a devastating condition for patients and surgeons. Although various methods are described to surgically deal with neuromas, some discontinuity and stump neuroma therapies have anatomical limitations. It is widely known that a neurotizable target for axon ingrowth is beneficial for dealing with neuromas. The nerve needs "something to do". Furthermore, sufficient soft tissue coverage plays a major role in sufficient neuroma therapy. We aimed, therefore, to demonstrate our approach for therapy of resistant neuromas with insufficient tissue coverage using free flaps, which are sensory neurotized via anatomical constant branches. The central idea is to provide a new target, a new "to do" for the painful mislead axons, as well as an augmentation of deficient soft tissues. As indication is key, we furthermore demonstrate clinical cases and common neurotizable workhorse flaps. |
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Although various methods are described to surgically deal with neuromas, some discontinuity and stump neuroma therapies have anatomical limitations. It is widely known that a neurotizable target for axon ingrowth is beneficial for dealing with neuromas. The nerve needs "something to do". Furthermore, sufficient soft tissue coverage plays a major role in sufficient neuroma therapy. We aimed, therefore, to demonstrate our approach for therapy of resistant neuromas with insufficient tissue coverage using free flaps, which are sensory neurotized via anatomical constant branches. The central idea is to provide a new target, a new "to do" for the painful mislead axons, as well as an augmentation of deficient soft tissues. As indication is key, we furthermore demonstrate clinical cases and common neurotizable workhorse flaps.</description><identifier>ISSN: 2075-4426</identifier><identifier>EISSN: 2075-4426</identifier><identifier>DOI: 10.3390/jpm13020313</identifier><identifier>PMID: 36836547</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Axon guidance ; Catheters ; Morbidity ; Pain ; Patients ; Precision medicine ; Scars ; Soft tissues ; Surgery ; Ultrasonic imaging ; Veins & arteries</subject><ispartof>Journal of personalized medicine, 2023-02, Vol.13 (2), p.313</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Although various methods are described to surgically deal with neuromas, some discontinuity and stump neuroma therapies have anatomical limitations. It is widely known that a neurotizable target for axon ingrowth is beneficial for dealing with neuromas. The nerve needs "something to do". Furthermore, sufficient soft tissue coverage plays a major role in sufficient neuroma therapy. We aimed, therefore, to demonstrate our approach for therapy of resistant neuromas with insufficient tissue coverage using free flaps, which are sensory neurotized via anatomical constant branches. The central idea is to provide a new target, a new "to do" for the painful mislead axons, as well as an augmentation of deficient soft tissues. As indication is key, we furthermore demonstrate clinical cases and common neurotizable workhorse flaps.</description><subject>Axon guidance</subject><subject>Catheters</subject><subject>Morbidity</subject><subject>Pain</subject><subject>Patients</subject><subject>Precision medicine</subject><subject>Scars</subject><subject>Soft tissues</subject><subject>Surgery</subject><subject>Ultrasonic imaging</subject><subject>Veins & arteries</subject><issn>2075-4426</issn><issn>2075-4426</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkt9rFDEQxxdRbKl98l0CvgiyNbv5_SIcp2eFog_ee8hlZ685ssma7Bbav95c7yxXMXnIMPl8JzOTqaq3Db4iROFPu3FoCG4xaciL6rzFgtWUtvzliX1WXea8w2VJ1rYcv67OCJeEMyrOq_k6juAhZ_QD5hQHU69v4WBP7gE6tEoAaOXNiNYu5xnQYt4OECYzuRiQyeiX8XdmC6jokhnv6wVaxmBhnJAJHVp6F5w1Hn2BIYY8pUfdm-pVb3yGy-N5Ua1XX9fL6_rm57fvy8VNbangU93RjQTRM4mpYY0gjeop6TCVQlBGLW14izfF05Om7XDHpKDKgpRM9IpTRS6qz4ew47wZoLMl7WS8HpMbTLrX0Tj9_Ca4W72Nd1opzgknJcCHY4AUf8-QJz24bMF7EyDOWbdCYixKM_fo-3_QXZxTKNUVSiiGG_aY0ZHaGg_ahT6Wd-0-qF6I8jtKtYwW6uo_VNkdDM7GAL0r_meCjweBTTHnBP1TjQ3W-znRJ3NS6HenbXli_04F-QNTJba5</recordid><startdate>20230210</startdate><enddate>20230210</enddate><creator>Aman, Martin</creator><creator>Glaser, Julia J</creator><creator>Boecker, Arne H</creator><creator>Thielen, Mirjam</creator><creator>Eisa, Amr</creator><creator>Bigdeli, Amir K</creator><creator>Gazyakan, Emre</creator><creator>Kneser, Ulrich</creator><creator>Harhaus, Leila</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3580-8486</orcidid><orcidid>https://orcid.org/0000-0003-2826-2793</orcidid><orcidid>https://orcid.org/0000-0003-0337-8570</orcidid><orcidid>https://orcid.org/0000-0002-7061-0512</orcidid><orcidid>https://orcid.org/0000-0001-8852-5132</orcidid><orcidid>https://orcid.org/0000-0002-3402-2860</orcidid></search><sort><creationdate>20230210</creationdate><title>Hopeless Neuroma-The Neurotized Free Flap Tissue Augmentation as Salvage Therapy-A Concept and Clinical Demonstration</title><author>Aman, Martin ; 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subjects | Axon guidance Catheters Morbidity Pain Patients Precision medicine Scars Soft tissues Surgery Ultrasonic imaging Veins & arteries |
title | Hopeless Neuroma-The Neurotized Free Flap Tissue Augmentation as Salvage Therapy-A Concept and Clinical Demonstration |
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