Hopeless Neuroma-The Neurotized Free Flap Tissue Augmentation as Salvage Therapy-A Concept and Clinical Demonstration

Therapy-resistant neuroma pain is a devastating condition for patients and surgeons. Although various methods are described to surgically deal with neuromas, some discontinuity and stump neuroma therapies have anatomical limitations. It is widely known that a neurotizable target for axon ingrowth is...

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Veröffentlicht in:Journal of personalized medicine 2023-02, Vol.13 (2), p.313
Hauptverfasser: Aman, Martin, Glaser, Julia J, Boecker, Arne H, Thielen, Mirjam, Eisa, Amr, Bigdeli, Amir K, Gazyakan, Emre, Kneser, Ulrich, Harhaus, Leila
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container_issue 2
container_start_page 313
container_title Journal of personalized medicine
container_volume 13
creator Aman, Martin
Glaser, Julia J
Boecker, Arne H
Thielen, Mirjam
Eisa, Amr
Bigdeli, Amir K
Gazyakan, Emre
Kneser, Ulrich
Harhaus, Leila
description Therapy-resistant neuroma pain is a devastating condition for patients and surgeons. Although various methods are described to surgically deal with neuromas, some discontinuity and stump neuroma therapies have anatomical limitations. It is widely known that a neurotizable target for axon ingrowth is beneficial for dealing with neuromas. The nerve needs "something to do". Furthermore, sufficient soft tissue coverage plays a major role in sufficient neuroma therapy. We aimed, therefore, to demonstrate our approach for therapy of resistant neuromas with insufficient tissue coverage using free flaps, which are sensory neurotized via anatomical constant branches. The central idea is to provide a new target, a new "to do" for the painful mislead axons, as well as an augmentation of deficient soft tissues. As indication is key, we furthermore demonstrate clinical cases and common neurotizable workhorse flaps.
doi_str_mv 10.3390/jpm13020313
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source PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Axon guidance
Catheters
Morbidity
Pain
Patients
Precision medicine
Scars
Soft tissues
Surgery
Ultrasonic imaging
Veins & arteries
title Hopeless Neuroma-The Neurotized Free Flap Tissue Augmentation as Salvage Therapy-A Concept and Clinical Demonstration
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