Combined, functional genomic-biochemical approach to intermediary metabolism: interaction of acivicin, a glutamine amidotransferase inhibitor, with Escherichia coli K-12

Acivicin, a modified amino acid natural product, is a glutamine analog. Thus, it might interfere with metabolism by hindering glutamine transport, formation, or usage in processes such as transamidation and translation. This molecule prevented the growth of Escherichia coli in minimal medium unless...

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Veröffentlicht in:	Journal of bacteriology 2001-06, Vol.183 (11), p.3353-3364
Hauptverfasser:	Smulski, D R, Huang, L L, McCluskey, M P, Reeve, M J, Vollmer, A C, Van Dyk, T K, LaRossa, R A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acivicin Aminohydrolases - genetics Aminohydrolases - metabolism Anthranilate Synthase Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Binding, Competitive Biochemistry Culture Media Disease Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Escherichia coli Escherichia coli - drug effects Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - growth & development Escherichia coli - metabolism Gene Expression Profiling - methods Genetics and Molecular Biology Genomics glutamine Glutamine - metabolism Glutamine amidotransferase HisHF protein Imidazoles - metabolism Isoxazoles - metabolism Isoxazoles - pharmacology Metabolism Nitrogenous Group Transferases - antagonists & inhibitors Nitrogenous Group Transferases - genetics Nitrogenous Group Transferases - metabolism Ribonucleotides - metabolism Transaminases - genetics Transaminases - metabolism
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