Specialized pro-resolving mediators as modulators of immune responses
Specialized pro-resolving mediators (SPMs) are endogenous small molecules produced mainly from dietary omega-3 polyunsaturated fatty acids by both structural cells and cells of the active and innate immune systems. Specialized pro-resolving mediators have been shown to both limit acute inflammation...
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| Veröffentlicht in: | Seminars in immunology 2022-01, Vol.59, p.101605-101605, Article 101605 |
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| container_title | Seminars in immunology |
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| creator | Julliard, Walker A. Myo, Yu Par Aung Perelas, Apostolos Jackson, Peter D. Thatcher, Thomas H. Sime, Patricia J. |
| description | Specialized pro-resolving mediators (SPMs) are endogenous small molecules produced mainly from dietary omega-3 polyunsaturated fatty acids by both structural cells and cells of the active and innate immune systems. Specialized pro-resolving mediators have been shown to both limit acute inflammation and promote resolution and return to homeostasis following infection or injury. There is growing evidence that chronic immune disorders are characterized by deficiencies in resolution and SPMs have significant potential as novel therapeutics to prevent and treat chronic inflammation and immune system disorders. This review focuses on important breakthroughs in understanding how SPMs are produced by, and act on, cells of the adaptive immune system, specifically macrophages, B cells and T cells. We also highlight recent evidence demonstrating the potential of SPMs as novel therapeutic agents in topics including immunization, autoimmune disease and transplantation. |
| doi_str_mv | 10.1016/j.smim.2022.101605 |
| format | Article |
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Specialized pro-resolving mediators have been shown to both limit acute inflammation and promote resolution and return to homeostasis following infection or injury. There is growing evidence that chronic immune disorders are characterized by deficiencies in resolution and SPMs have significant potential as novel therapeutics to prevent and treat chronic inflammation and immune system disorders. This review focuses on important breakthroughs in understanding how SPMs are produced by, and act on, cells of the adaptive immune system, specifically macrophages, B cells and T cells. 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We also highlight recent evidence demonstrating the potential of SPMs as novel therapeutic agents in topics including immunization, autoimmune disease and transplantation.</description><subject>Adaptive immunity</subject><subject>Autoimmunity</subject><subject>B cells</subject><subject>Docosahexaenoic acid</subject><subject>Docosahexaenoic Acids - therapeutic use</subject><subject>Eicosapentaenoic acid</subject><subject>Fatty Acids, Omega-3 - therapeutic use</subject><subject>Humans</subject><subject>Immunity</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation Mediators - therapeutic use</subject><subject>Lipoxin</subject><subject>Macrophages</subject><subject>Maresin</subject><subject>Protectin</subject><subject>Resolution</subject><subject>Resolvin</subject><subject>Specialized pro-resolving mediators</subject><subject>T cells</subject><issn>1044-5323</issn><issn>1096-3618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1L5TAUhoOM-P0HZjF0OZteT5ImaUEGBvELBBfqOqTpqebSNp2kvTDz6821jujGVZKT57zn8BDyncKKApWn61XsXb9iwNhrAcQOOaBQyZxLWn7b3osiF5zxfXIY4xoAeFHSPbLPhZTAeXlALu5HtM507h822Rh8HjD6buOGp6zHxpnJh5iZmPW-mbvl5dvM9f08YJbY0Q8R4zHZbU0X8eTtPCKPlxcP59f57d3Vzfnv29wWQky5amXJhFU1NrSyStGiYggS6qJmqmgLgBZqYyrOAVtDTcksqKo1DJlUgiM_Ir-W3HGu03oWhymYTo_B9Sb81d44_flncM_6yW90VUmmJEsBP98Cgv8zY5x076LFrjMD-jnqNIeLSigBCWULaoOPMWD7PoaC3urWa731r7f-9eI_Nf34uOB7y3_hCThbAEyaNg6DjtbhYJPrgHbSjXdf5b8A3WuYWQ</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Julliard, Walker A.</creator><creator>Myo, Yu Par Aung</creator><creator>Perelas, Apostolos</creator><creator>Jackson, Peter D.</creator><creator>Thatcher, Thomas H.</creator><creator>Sime, Patricia J.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202201</creationdate><title>Specialized pro-resolving mediators as modulators of immune responses</title><author>Julliard, Walker A. ; Myo, Yu Par Aung ; Perelas, Apostolos ; Jackson, Peter D. ; Thatcher, Thomas H. ; Sime, Patricia J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-7f6825c7bed19c771492e060b4b274f400f0baa9330efa1a82c079fa2e26753e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adaptive immunity</topic><topic>Autoimmunity</topic><topic>B cells</topic><topic>Docosahexaenoic acid</topic><topic>Docosahexaenoic Acids - therapeutic use</topic><topic>Eicosapentaenoic acid</topic><topic>Fatty Acids, Omega-3 - therapeutic use</topic><topic>Humans</topic><topic>Immunity</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation Mediators - therapeutic use</topic><topic>Lipoxin</topic><topic>Macrophages</topic><topic>Maresin</topic><topic>Protectin</topic><topic>Resolution</topic><topic>Resolvin</topic><topic>Specialized pro-resolving mediators</topic><topic>T cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Julliard, Walker A.</creatorcontrib><creatorcontrib>Myo, Yu Par Aung</creatorcontrib><creatorcontrib>Perelas, Apostolos</creatorcontrib><creatorcontrib>Jackson, Peter D.</creatorcontrib><creatorcontrib>Thatcher, Thomas H.</creatorcontrib><creatorcontrib>Sime, Patricia J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Seminars in immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Julliard, Walker A.</au><au>Myo, Yu Par Aung</au><au>Perelas, Apostolos</au><au>Jackson, Peter D.</au><au>Thatcher, Thomas H.</au><au>Sime, Patricia J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specialized pro-resolving mediators as modulators of immune responses</atitle><jtitle>Seminars in immunology</jtitle><addtitle>Semin Immunol</addtitle><date>2022-01</date><risdate>2022</risdate><volume>59</volume><spage>101605</spage><epage>101605</epage><pages>101605-101605</pages><artnum>101605</artnum><issn>1044-5323</issn><eissn>1096-3618</eissn><abstract>Specialized pro-resolving mediators (SPMs) are endogenous small molecules produced mainly from dietary omega-3 polyunsaturated fatty acids by both structural cells and cells of the active and innate immune systems. 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| identifier | ISSN: 1044-5323 |
| ispartof | Seminars in immunology, 2022-01, Vol.59, p.101605-101605, Article 101605 |
| issn | 1044-5323 1096-3618 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adaptive immunity Autoimmunity B cells Docosahexaenoic acid Docosahexaenoic Acids - therapeutic use Eicosapentaenoic acid Fatty Acids, Omega-3 - therapeutic use Humans Immunity Inflammation Inflammation - drug therapy Inflammation Mediators - therapeutic use Lipoxin Macrophages Maresin Protectin Resolution Resolvin Specialized pro-resolving mediators T cells |
| title | Specialized pro-resolving mediators as modulators of immune responses |
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