Effect of Tight Glycemic Control on Pancreatic Beta Cell Function in Newly Diagnosed Pediatric Type 1 Diabetes: A Randomized Clinical Trial

IMPORTANCE: Near normalization of glucose levels instituted immediately after diagnosis of type 1 diabetes has been postulated to preserve pancreatic beta cell function by reducing glucotoxicity. Previous studies have been hampered by an inability to achieve tight glycemic goals. OBJECTIVE: To deter...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2023-03, Vol.329 (12), p.980-989
Hauptverfasser:	McVean, Jennifer, Forlenza, Gregory P, Beck, Roy W, Bauza, Colleen, Bailey, Ryan, Buckingham, Bruce, DiMeglio, Linda A, Sherr, Jennifer L, Clements, Mark, Neyman, Anna, Evans-Molina, Carmella, Sims, Emily K, Messer, Laurel H, Ekhlaspour, Laya, McDonough, Ryan, Van Name, Michelle, Rojas, Diana, Beasley, Shannon, DuBose, Stephanie, Kollman, Craig, Moran, Antoinette
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Automation Beta cells Blood Glucose - drug effects Blood Glucose Self-Monitoring C-Peptide - pharmacology C-Peptide - therapeutic use Child Clinical trials Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - drug therapy Diabetic ketoacidosis Diagnosis Double-Blind Method Double-blind studies Factorial design Female Glucose Glucose monitoring Glycated Hemoglobin Glycemic Control Humans Hypoglycemia Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - adverse effects Insulin Insulin - administration & dosage Insulin - adverse effects Insulin-Secreting Cells - drug effects Ketoacidosis Management Online First Original Investigation Pancreas Pediatrics Peptides Randomization Verapamil
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