Autophagy and the Insulin-like Growth Factor (IGF) System in Colonic Cells: Implications for Colorectal Neoplasia

Colorectal cancer (CRC) is one of the most common human malignancies worldwide. Along with apoptosis and inflammation, autophagy is one of three important mechanisms in CRC. The presence of autophagy/mitophagy in most normal mature intestinal epithelial cells has been confirmed, where it has mainly...

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Veröffentlicht in:	International journal of molecular sciences 2023-02, Vol.24 (4), p.3665
1. Verfasser:	Kasprzak, Aldona
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiinfectives and antibacterials Antimicrobial peptides Apoptosis Autophagy B cells Carcinogenesis Carcinogens Cell differentiation Cell growth Cell proliferation Colon - metabolism Colon - pathology Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Development and progression Differentiation DNA damage Dysbacteriosis Epithelial cells Epithelium Gastrointestinal diseases Growth factors Heterogeneity Humans Inflammatory bowel disease Inflammatory bowel diseases Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Insulin-like growth factors Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestine Kinases Malignancy Metabolic disorders Metabolic syndrome Microorganisms Molecular modelling Mucin Mucins Mutation Panitumumab Peptides Physiological aspects Protein binding Protein turnover Proteins Reactive oxygen species Receptor, IGF Type 1 - metabolism Review Signal Transduction Tumor Microenvironment
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