ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines
A limited number of studies are devoted to regulating expression in cancer. Hence, we aimed to unveil the regulation of expression in MCF-7 breast cancer cells (with high expression) and taxane-resistant MCF-7 sublines (manifesting even higher expression). We found that transcription is regulated pr...
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| Veröffentlicht in: | Genes 2023-01, Vol.14 (2), p.296 |
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| creator | Daniel, Petr Balušíková, Kamila Václavíková, Radka Šeborová, Karolína Ransdorfová, Šárka Valeriánová, Marie Wei, Longfei Jelínek, Michael Tlapáková, Tereza Fleischer, Thomas Kristensen, Vessela N Souček, Pavel Ojima, Iwao Kovář, Jan |
| description | A limited number of studies are devoted to regulating
expression in cancer. Hence, we aimed to unveil the regulation of
expression in MCF-7 breast cancer cells (with high
expression) and taxane-resistant MCF-7 sublines (manifesting even higher
expression). We found that
transcription is regulated primarily by the cyclic AMP response element (CRE) in hypomethylated proximal promoters in both taxane-sensitive and taxane-resistant MCF-7 cells. Furthermore, in taxane-resistant MCF-7 sublines,
co-amplification with the neighboring
gene, as witnessed by fluorescence in situ hybridization (FISH), led to
overexpression. Ultimately, we found high
mRNA levels in progesterone receptor-positive breast cancer and samples resected from premenopausal women. |
| doi_str_mv | 10.3390/genes14020296 |
| format | Article |
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expression in cancer. Hence, we aimed to unveil the regulation of
expression in MCF-7 breast cancer cells (with high
expression) and taxane-resistant MCF-7 sublines (manifesting even higher
expression). We found that
transcription is regulated primarily by the cyclic AMP response element (CRE) in hypomethylated proximal promoters in both taxane-sensitive and taxane-resistant MCF-7 cells. Furthermore, in taxane-resistant MCF-7 sublines,
co-amplification with the neighboring
gene, as witnessed by fluorescence in situ hybridization (FISH), led to
overexpression. Ultimately, we found high
mRNA levels in progesterone receptor-positive breast cancer and samples resected from premenopausal women.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes14020296</identifier><identifier>PMID: 36833223</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adaptor Proteins, Signal Transducing - genetics ; ATP Binding Cassette Transporter, Subfamily B - genetics ; Breast cancer ; Cells ; Chromosomes ; Colorectal cancer ; Cyclic AMP ; Drug Resistance, Neoplasm - genetics ; Estrogens ; Female ; Fluorescence in situ hybridization ; Gene expression ; Humans ; Hybridization ; In Situ Hybridization, Fluorescence ; LIM Domain Proteins - genetics ; MCF-7 Cells ; MicroRNAs ; Neoplasms - genetics ; Patients ; Progesterone ; Proteins ; Response Elements ; Surgery ; Taxanes ; Taxoids ; Transcription Factors - genetics</subject><ispartof>Genes, 2023-01, Vol.14 (2), p.296</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>info:eu-repo/semantics/openAccess</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-52266065fadfdd88ef4ddb44c8100e6581a4e6a31b24a0c8f6b961897056ae603</citedby><cites>FETCH-LOGICAL-c440t-52266065fadfdd88ef4ddb44c8100e6581a4e6a31b24a0c8f6b961897056ae603</cites><orcidid>0000-0001-8841-1573 ; 0000-0002-8925-2321 ; 0000-0001-9432-8960 ; 0000-0002-4294-6799 ; 0000-0002-5523-4184 ; 0000-0003-0985-8460 ; 0000-0002-3628-1161 ; 0000-0002-0471-5877</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957548/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957548/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,26544,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36833223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daniel, Petr</creatorcontrib><creatorcontrib>Balušíková, Kamila</creatorcontrib><creatorcontrib>Václavíková, Radka</creatorcontrib><creatorcontrib>Šeborová, Karolína</creatorcontrib><creatorcontrib>Ransdorfová, Šárka</creatorcontrib><creatorcontrib>Valeriánová, Marie</creatorcontrib><creatorcontrib>Wei, Longfei</creatorcontrib><creatorcontrib>Jelínek, Michael</creatorcontrib><creatorcontrib>Tlapáková, Tereza</creatorcontrib><creatorcontrib>Fleischer, Thomas</creatorcontrib><creatorcontrib>Kristensen, Vessela N</creatorcontrib><creatorcontrib>Souček, Pavel</creatorcontrib><creatorcontrib>Ojima, Iwao</creatorcontrib><creatorcontrib>Kovář, Jan</creatorcontrib><title>ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines</title><title>Genes</title><addtitle>Genes (Basel)</addtitle><description>A limited number of studies are devoted to regulating
expression in cancer. Hence, we aimed to unveil the regulation of
expression in MCF-7 breast cancer cells (with high
expression) and taxane-resistant MCF-7 sublines (manifesting even higher
expression). We found that
transcription is regulated primarily by the cyclic AMP response element (CRE) in hypomethylated proximal promoters in both taxane-sensitive and taxane-resistant MCF-7 cells. Furthermore, in taxane-resistant MCF-7 sublines,
co-amplification with the neighboring
gene, as witnessed by fluorescence in situ hybridization (FISH), led to
overexpression. Ultimately, we found high
mRNA levels in progesterone receptor-positive breast cancer and samples resected from premenopausal women.</description><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>ATP Binding Cassette Transporter, Subfamily B - genetics</subject><subject>Breast cancer</subject><subject>Cells</subject><subject>Chromosomes</subject><subject>Colorectal cancer</subject><subject>Cyclic AMP</subject><subject>Drug Resistance, Neoplasm - genetics</subject><subject>Estrogens</subject><subject>Female</subject><subject>Fluorescence in situ hybridization</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Hybridization</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>LIM Domain Proteins - genetics</subject><subject>MCF-7 Cells</subject><subject>MicroRNAs</subject><subject>Neoplasms - genetics</subject><subject>Patients</subject><subject>Progesterone</subject><subject>Proteins</subject><subject>Response Elements</subject><subject>Surgery</subject><subject>Taxanes</subject><subject>Taxoids</subject><subject>Transcription Factors - genetics</subject><issn>2073-4425</issn><issn>2073-4425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>3HK</sourceid><recordid>eNpdkctv1DAQxi0EolXpkSuyxIVLqN9xLki7oS-pFVUpZ8txJsVVYi92sqL_PV71oRYf7LH90zffzCD0kZKvnDfk6BYCZCoII6xRb9A-IzWvhGDy7Yt4Dx3mfEfK2oFEvkd7XGnOGeP7aLtat2uKV9Nm9C4G3MYwWx8ybu9decGryyt8DXkTQwZ8PMIEYa6-J7-FgG-uz68UPi0esC83-9cGqArs82zDjC_bk6rG6wQ2z7i1wUHCP5du9MXzB_RusGOGw8fzAP06Ob5pz6qLH6fn7eqickKQuZKMKUWUHGw_9L3WMIi-74RwmhICSmpqBSjLaceEJU4PqmsU1U1NpLKgCD9A3x50N0s3Qe-K-2RHs0l-suneROvN65_gf5vbuDVNI2spdBHADwIulbJ8MCEmayjRku12JVRBvjzmSPHPAnk2k88OxrG0Iy7ZsFoTooTQdUE__4fexSWF0oFC1Y1oGq5loaqnnDHnBMOzX0rMbu7m1dwL_-llkc_005T5P9YDpe0</recordid><startdate>20230123</startdate><enddate>20230123</enddate><creator>Daniel, Petr</creator><creator>Balušíková, Kamila</creator><creator>Václavíková, Radka</creator><creator>Šeborová, Karolína</creator><creator>Ransdorfová, Šárka</creator><creator>Valeriánová, Marie</creator><creator>Wei, Longfei</creator><creator>Jelínek, Michael</creator><creator>Tlapáková, Tereza</creator><creator>Fleischer, Thomas</creator><creator>Kristensen, Vessela N</creator><creator>Souček, Pavel</creator><creator>Ojima, Iwao</creator><creator>Kovář, Jan</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>3HK</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8841-1573</orcidid><orcidid>https://orcid.org/0000-0002-8925-2321</orcidid><orcidid>https://orcid.org/0000-0001-9432-8960</orcidid><orcidid>https://orcid.org/0000-0002-4294-6799</orcidid><orcidid>https://orcid.org/0000-0002-5523-4184</orcidid><orcidid>https://orcid.org/0000-0003-0985-8460</orcidid><orcidid>https://orcid.org/0000-0002-3628-1161</orcidid><orcidid>https://orcid.org/0000-0002-0471-5877</orcidid></search><sort><creationdate>20230123</creationdate><title>ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines</title><author>Daniel, Petr ; Balušíková, Kamila ; Václavíková, Radka ; Šeborová, Karolína ; Ransdorfová, Šárka ; Valeriánová, Marie ; Wei, Longfei ; Jelínek, Michael ; Tlapáková, Tereza ; Fleischer, Thomas ; Kristensen, Vessela N ; Souček, Pavel ; Ojima, Iwao ; Kovář, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-52266065fadfdd88ef4ddb44c8100e6581a4e6a31b24a0c8f6b961897056ae603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adaptor Proteins, Signal Transducing - genetics</topic><topic>ATP Binding Cassette Transporter, Subfamily B - genetics</topic><topic>Breast cancer</topic><topic>Cells</topic><topic>Chromosomes</topic><topic>Colorectal cancer</topic><topic>Cyclic AMP</topic><topic>Drug Resistance, Neoplasm - genetics</topic><topic>Estrogens</topic><topic>Female</topic><topic>Fluorescence in situ hybridization</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Hybridization</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>LIM Domain Proteins - genetics</topic><topic>MCF-7 Cells</topic><topic>MicroRNAs</topic><topic>Neoplasms - genetics</topic><topic>Patients</topic><topic>Progesterone</topic><topic>Proteins</topic><topic>Response Elements</topic><topic>Surgery</topic><topic>Taxanes</topic><topic>Taxoids</topic><topic>Transcription Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daniel, Petr</creatorcontrib><creatorcontrib>Balušíková, Kamila</creatorcontrib><creatorcontrib>Václavíková, Radka</creatorcontrib><creatorcontrib>Šeborová, Karolína</creatorcontrib><creatorcontrib>Ransdorfová, Šárka</creatorcontrib><creatorcontrib>Valeriánová, Marie</creatorcontrib><creatorcontrib>Wei, Longfei</creatorcontrib><creatorcontrib>Jelínek, Michael</creatorcontrib><creatorcontrib>Tlapáková, Tereza</creatorcontrib><creatorcontrib>Fleischer, Thomas</creatorcontrib><creatorcontrib>Kristensen, Vessela N</creatorcontrib><creatorcontrib>Souček, Pavel</creatorcontrib><creatorcontrib>Ojima, Iwao</creatorcontrib><creatorcontrib>Kovář, Jan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daniel, Petr</au><au>Balušíková, Kamila</au><au>Václavíková, Radka</au><au>Šeborová, Karolína</au><au>Ransdorfová, Šárka</au><au>Valeriánová, Marie</au><au>Wei, Longfei</au><au>Jelínek, Michael</au><au>Tlapáková, Tereza</au><au>Fleischer, Thomas</au><au>Kristensen, Vessela N</au><au>Souček, Pavel</au><au>Ojima, Iwao</au><au>Kovář, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines</atitle><jtitle>Genes</jtitle><addtitle>Genes (Basel)</addtitle><date>2023-01-23</date><risdate>2023</risdate><volume>14</volume><issue>2</issue><spage>296</spage><pages>296-</pages><issn>2073-4425</issn><eissn>2073-4425</eissn><abstract>A limited number of studies are devoted to regulating
expression in cancer. Hence, we aimed to unveil the regulation of
expression in MCF-7 breast cancer cells (with high
expression) and taxane-resistant MCF-7 sublines (manifesting even higher
expression). We found that
transcription is regulated primarily by the cyclic AMP response element (CRE) in hypomethylated proximal promoters in both taxane-sensitive and taxane-resistant MCF-7 cells. Furthermore, in taxane-resistant MCF-7 sublines,
co-amplification with the neighboring
gene, as witnessed by fluorescence in situ hybridization (FISH), led to
overexpression. Ultimately, we found high
mRNA levels in progesterone receptor-positive breast cancer and samples resected from premenopausal women.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36833223</pmid><doi>10.3390/genes14020296</doi><orcidid>https://orcid.org/0000-0001-8841-1573</orcidid><orcidid>https://orcid.org/0000-0002-8925-2321</orcidid><orcidid>https://orcid.org/0000-0001-9432-8960</orcidid><orcidid>https://orcid.org/0000-0002-4294-6799</orcidid><orcidid>https://orcid.org/0000-0002-5523-4184</orcidid><orcidid>https://orcid.org/0000-0003-0985-8460</orcidid><orcidid>https://orcid.org/0000-0002-3628-1161</orcidid><orcidid>https://orcid.org/0000-0002-0471-5877</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; NORA - Norwegian Open Research Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adaptor Proteins, Signal Transducing - genetics ATP Binding Cassette Transporter, Subfamily B - genetics Breast cancer Cells Chromosomes Colorectal cancer Cyclic AMP Drug Resistance, Neoplasm - genetics Estrogens Female Fluorescence in situ hybridization Gene expression Humans Hybridization In Situ Hybridization, Fluorescence LIM Domain Proteins - genetics MCF-7 Cells MicroRNAs Neoplasms - genetics Patients Progesterone Proteins Response Elements Surgery Taxanes Taxoids Transcription Factors - genetics |
| title | ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines |
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