Natural History of Anal HPV Infection in Women Treated for Cervical Intraepithelial Neoplasia
Women with high-grade squamous intraepithelial lesions/cervical intraepithelial neoplasia (HSIL/CIN) are at high risk of anal human papillomavirus HPV infection, and it has also been suggested that self-inoculation of the virus from the anal canal to the cervix could explain HPV recurrence in the ce...
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| Veröffentlicht in: | Cancers 2023-02, Vol.15 (4), p.1147 |
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| creator | Pino, Marta Del Matas, Isabel Carrillo, Pilar Martí, Cristina Glickman, Ariel Carreras-Dieguez, Núria Marimon, Lorena Saco, Adela Rakislova, Natalia Torné, Aureli Ordi, Jaume |
| description | Women with high-grade squamous intraepithelial lesions/cervical intraepithelial neoplasia (HSIL/CIN) are at high risk of anal human papillomavirus HPV infection, and it has also been suggested that self-inoculation of the virus from the anal canal to the cervix could explain HPV recurrence in the cervix after treatment of HSIL/CIN. We aimed to evaluate the bidirectional interactions of HPV infection between these two anatomical sites. We evaluated 68 immunocompetent women undergoing excisional treatment for HSIL/CIN. Immediately before treatment, samples from the anus and the cervix were obtained (baseline anal and cervical HPV status). Cervical HPV clearance after treatment was defined as treatment success. The first follow-up control was scheduled 4-6 months after treatment for cervical and anal samples. High resolution anoscopy (HRA) was performed on patients with persistent anal HPV infections or abnormal anal cytology in the first control. Baseline anal HPV was positive in 42/68 (61.8%) of the women. Anal HPV infection persisted after treatment in 29/68 (42.6%) of the women. One-third of these women (10/29; 34.5%) had HSIL/anal intraepithelial neoplasia (AIN). Among women achieving treatment success, cervical HPV in the first control was positive in 34.6% and 17.6% of the patients with positive and negative baseline anal HPV infection, respectively (
= 0.306). In conclusion, patients with persisting anal HPV after HSIL/CIN treatment are at high risk of HSIL/AIN, suggesting that these women would benefit from anal exploration. The study also suggests that women with anal HPV infection treated for HSIL/CIN might be at higher risk of recurrent cervical HPV even after successful treatment. |
| doi_str_mv | 10.3390/cancers15041147 |
| format | Article |
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= 0.306). In conclusion, patients with persisting anal HPV after HSIL/CIN treatment are at high risk of HSIL/AIN, suggesting that these women would benefit from anal exploration. The study also suggests that women with anal HPV infection treated for HSIL/CIN might be at higher risk of recurrent cervical HPV even after successful treatment.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers15041147</identifier><identifier>PMID: 36831490</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Anus ; Cancer ; Care and treatment ; Cellular biology ; Cervical cancer ; Cervix ; Cytology ; Exploration ; Genetic aspects ; HIV ; Human immunodeficiency virus ; Human papillomavirus ; Immunization ; Immunocompetence ; Infections ; Inoculation ; Medical screening ; Natural history ; Papillomavirus infections ; Recurrent infection</subject><ispartof>Cancers, 2023-02, Vol.15 (4), p.1147</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-84bdb38f2be644e1ab8fd1b33a342b6dde94c37688f28bffcafadbbed24ca6923</citedby><cites>FETCH-LOGICAL-c488t-84bdb38f2be644e1ab8fd1b33a342b6dde94c37688f28bffcafadbbed24ca6923</cites><orcidid>0000-0002-7147-3599 ; 0000-0003-2178-2403 ; 0000-0002-4820-7954 ; 0000-0002-2943-3550 ; 0000-0003-4700-9507</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954768/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954768/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36831490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pino, Marta Del</creatorcontrib><creatorcontrib>Matas, Isabel</creatorcontrib><creatorcontrib>Carrillo, Pilar</creatorcontrib><creatorcontrib>Martí, Cristina</creatorcontrib><creatorcontrib>Glickman, Ariel</creatorcontrib><creatorcontrib>Carreras-Dieguez, Núria</creatorcontrib><creatorcontrib>Marimon, Lorena</creatorcontrib><creatorcontrib>Saco, Adela</creatorcontrib><creatorcontrib>Rakislova, Natalia</creatorcontrib><creatorcontrib>Torné, Aureli</creatorcontrib><creatorcontrib>Ordi, Jaume</creatorcontrib><title>Natural History of Anal HPV Infection in Women Treated for Cervical Intraepithelial Neoplasia</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Women with high-grade squamous intraepithelial lesions/cervical intraepithelial neoplasia (HSIL/CIN) are at high risk of anal human papillomavirus HPV infection, and it has also been suggested that self-inoculation of the virus from the anal canal to the cervix could explain HPV recurrence in the cervix after treatment of HSIL/CIN. We aimed to evaluate the bidirectional interactions of HPV infection between these two anatomical sites. We evaluated 68 immunocompetent women undergoing excisional treatment for HSIL/CIN. Immediately before treatment, samples from the anus and the cervix were obtained (baseline anal and cervical HPV status). Cervical HPV clearance after treatment was defined as treatment success. The first follow-up control was scheduled 4-6 months after treatment for cervical and anal samples. High resolution anoscopy (HRA) was performed on patients with persistent anal HPV infections or abnormal anal cytology in the first control. Baseline anal HPV was positive in 42/68 (61.8%) of the women. Anal HPV infection persisted after treatment in 29/68 (42.6%) of the women. One-third of these women (10/29; 34.5%) had HSIL/anal intraepithelial neoplasia (AIN). Among women achieving treatment success, cervical HPV in the first control was positive in 34.6% and 17.6% of the patients with positive and negative baseline anal HPV infection, respectively (
= 0.306). In conclusion, patients with persisting anal HPV after HSIL/CIN treatment are at high risk of HSIL/AIN, suggesting that these women would benefit from anal exploration. The study also suggests that women with anal HPV infection treated for HSIL/CIN might be at higher risk of recurrent cervical HPV even after successful treatment.</description><subject>Anus</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Cellular biology</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Cytology</subject><subject>Exploration</subject><subject>Genetic aspects</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Human papillomavirus</subject><subject>Immunization</subject><subject>Immunocompetence</subject><subject>Infections</subject><subject>Inoculation</subject><subject>Medical screening</subject><subject>Natural history</subject><subject>Papillomavirus infections</subject><subject>Recurrent infection</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1rHSEUhofS0IQk6-6K0E03N_HrjropXC5tcyEkXaTtqog6x8Qwo7c6E8i_r0O-Q3ThOfqcVz28TfOR4CPGFD52JjrIhSwxJ4SLd80exYIu2lbx98_i3eawlGtcB2NEtOJDs8tayQhXeK_5e2bGKZsenYQypnyLkkerOOc_f6NN9ODGkCIKEf1JA0R0kcGM0CGfMlpDvgmusps4ZgPbMF5BH2p-BmnbmxLMQbPjTV_g8H7db359_3axPlmcnv_YrFenC8elHBeS284y6amFlnMgxkrfEcuYYZzatutAccdEKysirffOeNNZCx3lzrSKsv3m653udrIDdA7mB_V6m8Ng8q1OJuiXJzFc6ct0o5Va8qpbBb7cC-T0b4Iy6iEUB31vIqSpaCokxoJwgiv6-RV6naZcWzZTQi2pIlQ9UZemBx2iT_VeN4vqleAME0yoqNTRG1SdHQzBpQg-1P0XBcd3BS6nUjL4xz8SrGdT6FemqBWfnrfmkX-wAPsPqxGz-w</recordid><startdate>20230210</startdate><enddate>20230210</enddate><creator>Pino, Marta Del</creator><creator>Matas, Isabel</creator><creator>Carrillo, Pilar</creator><creator>Martí, Cristina</creator><creator>Glickman, Ariel</creator><creator>Carreras-Dieguez, Núria</creator><creator>Marimon, Lorena</creator><creator>Saco, Adela</creator><creator>Rakislova, Natalia</creator><creator>Torné, Aureli</creator><creator>Ordi, Jaume</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7147-3599</orcidid><orcidid>https://orcid.org/0000-0003-2178-2403</orcidid><orcidid>https://orcid.org/0000-0002-4820-7954</orcidid><orcidid>https://orcid.org/0000-0002-2943-3550</orcidid><orcidid>https://orcid.org/0000-0003-4700-9507</orcidid></search><sort><creationdate>20230210</creationdate><title>Natural History of Anal HPV Infection in Women Treated for Cervical Intraepithelial Neoplasia</title><author>Pino, Marta Del ; 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We aimed to evaluate the bidirectional interactions of HPV infection between these two anatomical sites. We evaluated 68 immunocompetent women undergoing excisional treatment for HSIL/CIN. Immediately before treatment, samples from the anus and the cervix were obtained (baseline anal and cervical HPV status). Cervical HPV clearance after treatment was defined as treatment success. The first follow-up control was scheduled 4-6 months after treatment for cervical and anal samples. High resolution anoscopy (HRA) was performed on patients with persistent anal HPV infections or abnormal anal cytology in the first control. Baseline anal HPV was positive in 42/68 (61.8%) of the women. Anal HPV infection persisted after treatment in 29/68 (42.6%) of the women. One-third of these women (10/29; 34.5%) had HSIL/anal intraepithelial neoplasia (AIN). Among women achieving treatment success, cervical HPV in the first control was positive in 34.6% and 17.6% of the patients with positive and negative baseline anal HPV infection, respectively (
= 0.306). In conclusion, patients with persisting anal HPV after HSIL/CIN treatment are at high risk of HSIL/AIN, suggesting that these women would benefit from anal exploration. The study also suggests that women with anal HPV infection treated for HSIL/CIN might be at higher risk of recurrent cervical HPV even after successful treatment.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36831490</pmid><doi>10.3390/cancers15041147</doi><orcidid>https://orcid.org/0000-0002-7147-3599</orcidid><orcidid>https://orcid.org/0000-0003-2178-2403</orcidid><orcidid>https://orcid.org/0000-0002-4820-7954</orcidid><orcidid>https://orcid.org/0000-0002-2943-3550</orcidid><orcidid>https://orcid.org/0000-0003-4700-9507</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Anus Cancer Care and treatment Cellular biology Cervical cancer Cervix Cytology Exploration Genetic aspects HIV Human immunodeficiency virus Human papillomavirus Immunization Immunocompetence Infections Inoculation Medical screening Natural history Papillomavirus infections Recurrent infection |
| title | Natural History of Anal HPV Infection in Women Treated for Cervical Intraepithelial Neoplasia |
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