Lithium in Cancer Therapy: Friend or Foe?
Lithium, a trace element important for fetal health and development, is considered a metal drug with a well-established clinical regime, economical production process, and a mature storage system. Several studies have shown that lithium affects tumor development by regulating inositol monophosphate...
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| Veröffentlicht in: | Cancers 2023-02, Vol.15 (4), p.1095 |
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| creator | Yang, Chunhao Zhu, Bo Zhan, Mingjie Hua, Zi-Chun |
| description | Lithium, a trace element important for fetal health and development, is considered a metal drug with a well-established clinical regime, economical production process, and a mature storage system. Several studies have shown that lithium affects tumor development by regulating inositol monophosphate (IMPase) and glycogen synthase kinase-3 (GSK-3). Lithium can also promote proliferation and programmed cell death (PCD) in tumor cells through a number of new targets, such as the nuclear receptor NR4A1 and Hedgehog-Gli. Lithium may increase cancer treatment efficacy while reducing side effects, suggesting that it can be used as an adjunctive therapy. In this review, we summarize the effects of lithium on tumor progression and discuss the underlying mechanisms. Additionally, we discuss lithium's limitations in antitumor clinical applications, including its narrow therapeutic window and potential pro-cancer effects on the tumor immune system. |
| doi_str_mv | 10.3390/cancers15041095 |
| format | Article |
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Several studies have shown that lithium affects tumor development by regulating inositol monophosphate (IMPase) and glycogen synthase kinase-3 (GSK-3). Lithium can also promote proliferation and programmed cell death (PCD) in tumor cells through a number of new targets, such as the nuclear receptor NR4A1 and Hedgehog-Gli. Lithium may increase cancer treatment efficacy while reducing side effects, suggesting that it can be used as an adjunctive therapy. In this review, we summarize the effects of lithium on tumor progression and discuss the underlying mechanisms. Additionally, we discuss lithium's limitations in antitumor clinical applications, including its narrow therapeutic window and potential pro-cancer effects on the tumor immune system.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers15041095</identifier><identifier>PMID: 36831437</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antitumor activity ; Apoptosis ; Autophagy ; Binding sites ; Bisphosphonates ; Cachexia ; Cancer ; Cancer therapies ; Care and treatment ; Catalysis ; Cell death ; Cell proliferation ; Chemotherapy ; Chloride ; Dosage and administration ; Drug resistance ; Enzymes ; Fetuses ; Glycogen ; Glycogen synthase kinase 3 ; Hypotheses ; Immune system ; Inositol monophosphate ; Kinases ; Leukemia ; Ligands ; Lithium ; Magnesium ; Melanoma ; Metabolism ; Phosphatase ; Phosphorylation ; Proteins ; Review ; Side effects ; Signal transduction ; Sodium ; Tumor cells ; Tumor necrosis factor-TNF ; Tumors</subject><ispartof>Cancers, 2023-02, Vol.15 (4), p.1095</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Several studies have shown that lithium affects tumor development by regulating inositol monophosphate (IMPase) and glycogen synthase kinase-3 (GSK-3). Lithium can also promote proliferation and programmed cell death (PCD) in tumor cells through a number of new targets, such as the nuclear receptor NR4A1 and Hedgehog-Gli. Lithium may increase cancer treatment efficacy while reducing side effects, suggesting that it can be used as an adjunctive therapy. In this review, we summarize the effects of lithium on tumor progression and discuss the underlying mechanisms. Additionally, we discuss lithium's limitations in antitumor clinical applications, including its narrow therapeutic window and potential pro-cancer effects on the tumor immune system.</description><subject>Antitumor activity</subject><subject>Apoptosis</subject><subject>Autophagy</subject><subject>Binding sites</subject><subject>Bisphosphonates</subject><subject>Cachexia</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Catalysis</subject><subject>Cell death</subject><subject>Cell proliferation</subject><subject>Chemotherapy</subject><subject>Chloride</subject><subject>Dosage and administration</subject><subject>Drug resistance</subject><subject>Enzymes</subject><subject>Fetuses</subject><subject>Glycogen</subject><subject>Glycogen synthase kinase 3</subject><subject>Hypotheses</subject><subject>Immune system</subject><subject>Inositol monophosphate</subject><subject>Kinases</subject><subject>Leukemia</subject><subject>Ligands</subject><subject>Lithium</subject><subject>Magnesium</subject><subject>Melanoma</subject><subject>Metabolism</subject><subject>Phosphatase</subject><subject>Phosphorylation</subject><subject>Proteins</subject><subject>Review</subject><subject>Side effects</subject><subject>Signal transduction</subject><subject>Sodium</subject><subject>Tumor cells</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumors</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkUFvGyEQhVGVqI6cnHurVuolOTiBHXZZckgVWXVbyVIv7hmxeLCxdsEFb6X8--AmcZyocGAE730zwxDyidFrAElvjPYGY2IV5YzK6gM5K6koJ3Ut-clRPCIXKW1oXgBM1OIjGUHdAOMgzsjV3O3WbugL54vpP16xWGPU24fbYhYd-mURYjEL-PWcnFrdJbx4Psfk9-zbYvpjMv_1_ef0fj4xvGl2E2Z1IwVqY1tboQZdAgiwklkm2pJbCxJbA0Ja5I2lLWqLJZTcmBpoyyoYk7sn7nZoe1wa9LuoO7WNrtfxQQXt1NsX79ZqFf4qKSteC54Bl8-AGP4MmHaqd8lg12mPYUiqFA2lgkEubEy-vJNuwhB9bi-rhORV2TTiVbXSHSrnbch5zR6q7nM-yjJuX_f1f1R5L7F3Jni0Lt-_Mdw8GUwMKUW0hx4ZVfsBq3cDzo7Px19z0L-MEx4BiiWftw</recordid><startdate>20230208</startdate><enddate>20230208</enddate><creator>Yang, Chunhao</creator><creator>Zhu, Bo</creator><creator>Zhan, Mingjie</creator><creator>Hua, Zi-Chun</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6043-8774</orcidid></search><sort><creationdate>20230208</creationdate><title>Lithium in Cancer Therapy: Friend or Foe?</title><author>Yang, Chunhao ; Zhu, Bo ; Zhan, Mingjie ; Hua, Zi-Chun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-1fa897eacfbf5ea3a23373f91f17b24ff39ebc379fe48f0beafe2324cc630b153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antitumor activity</topic><topic>Apoptosis</topic><topic>Autophagy</topic><topic>Binding sites</topic><topic>Bisphosphonates</topic><topic>Cachexia</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Catalysis</topic><topic>Cell death</topic><topic>Cell proliferation</topic><topic>Chemotherapy</topic><topic>Chloride</topic><topic>Dosage and administration</topic><topic>Drug resistance</topic><topic>Enzymes</topic><topic>Fetuses</topic><topic>Glycogen</topic><topic>Glycogen synthase kinase 3</topic><topic>Hypotheses</topic><topic>Immune system</topic><topic>Inositol monophosphate</topic><topic>Kinases</topic><topic>Leukemia</topic><topic>Ligands</topic><topic>Lithium</topic><topic>Magnesium</topic><topic>Melanoma</topic><topic>Metabolism</topic><topic>Phosphatase</topic><topic>Phosphorylation</topic><topic>Proteins</topic><topic>Review</topic><topic>Side effects</topic><topic>Signal transduction</topic><topic>Sodium</topic><topic>Tumor cells</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Chunhao</creatorcontrib><creatorcontrib>Zhu, Bo</creatorcontrib><creatorcontrib>Zhan, Mingjie</creatorcontrib><creatorcontrib>Hua, Zi-Chun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Chunhao</au><au>Zhu, Bo</au><au>Zhan, Mingjie</au><au>Hua, Zi-Chun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lithium in Cancer Therapy: Friend or Foe?</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2023-02-08</date><risdate>2023</risdate><volume>15</volume><issue>4</issue><spage>1095</spage><pages>1095-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Lithium, a trace element important for fetal health and development, is considered a metal drug with a well-established clinical regime, economical production process, and a mature storage system. Several studies have shown that lithium affects tumor development by regulating inositol monophosphate (IMPase) and glycogen synthase kinase-3 (GSK-3). Lithium can also promote proliferation and programmed cell death (PCD) in tumor cells through a number of new targets, such as the nuclear receptor NR4A1 and Hedgehog-Gli. Lithium may increase cancer treatment efficacy while reducing side effects, suggesting that it can be used as an adjunctive therapy. In this review, we summarize the effects of lithium on tumor progression and discuss the underlying mechanisms. Additionally, we discuss lithium's limitations in antitumor clinical applications, including its narrow therapeutic window and potential pro-cancer effects on the tumor immune system.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36831437</pmid><doi>10.3390/cancers15041095</doi><orcidid>https://orcid.org/0000-0001-6043-8774</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Antitumor activity Apoptosis Autophagy Binding sites Bisphosphonates Cachexia Cancer Cancer therapies Care and treatment Catalysis Cell death Cell proliferation Chemotherapy Chloride Dosage and administration Drug resistance Enzymes Fetuses Glycogen Glycogen synthase kinase 3 Hypotheses Immune system Inositol monophosphate Kinases Leukemia Ligands Lithium Magnesium Melanoma Metabolism Phosphatase Phosphorylation Proteins Review Side effects Signal transduction Sodium Tumor cells Tumor necrosis factor-TNF Tumors |
| title | Lithium in Cancer Therapy: Friend or Foe? |
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