Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study

Based on its wide range of immunosuppressive properties, hydroxychloroquine (HCQ) is used for the treatment of several autoimmune diseases. Limited literature is available on the relationship between HCQ concentration and its immunosuppressive effect. To gain insight in this relationship, we perform...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunologic research 2023-08, Vol.71 (4), p.617-627
Hauptverfasser:	in ‘t Veld, Aliede E., Grievink, Hendrika W., van der Plas, Johan L., Eveleens Maarse, Boukje C., van Kraaij, Sebastiaan J. W., Woutman, Tess D., Schoonakker, Mascha, Klarenbeek, Naomi B., de Kam, Marieke L., Kamerling, Ingrid M. C., Jansen, Manon A. A., Moerland, Matthijs
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Autoimmune diseases B-lymphocytes Biomedical and Life Sciences Biomedicine Cell growth Cell proliferation Clinical trials Cytokines drugs Health services humans Hydroxychloroquine Immunology Immunosuppression Internal Medicine Lymphocytes Lymphocytes B Lymphocytes T Medicine/Public Health Original Original Article Pharmacology Physicochemical properties Placebos T-lymphocytes TLR3 protein TLR7 protein TLR9 protein Toll-like receptors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!