Association of endometriosis with cardiovascular disease: Genetic aspects (Review)
Cardiovascular disease (CVD) comprises a broad spectrum of pathological conditions that affect the heart or blood vessels, including sequelae that arise from damaged vasculature in other organs of the body, such as the brain, kidneys or eyes. Atherosclerosis is a chronic inflammatory disease of the...
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| Veröffentlicht in: | International journal of molecular medicine 2023-03, Vol.51 (3), p.1, Article 29 |
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| creator | Vazgiourakis, Vassilios M Zervou, Maria I Papageorgiou, Louis Chaniotis, Dimitrios Spandidos, Demetrios A Vlachakis, Dimitrios Eliopoulos, Elias Goulielmos, George N |
| description | Cardiovascular disease (CVD) comprises a broad spectrum of pathological conditions that affect the heart or blood vessels, including sequelae that arise from damaged vasculature in other organs of the body, such as the brain, kidneys or eyes. Atherosclerosis is a chronic inflammatory disease of the arterial intima and is the primary cause of coronary artery disease, peripheral vascular disease, heart attack, stroke and renal pathology. It represents a leading cause of mortality worldwide and the loss of human productivity that is marked by an altered immune response. Endometriosis is a heritable, heterogeneous, common gynecological condition influenced by multiple genetic, epigenetic and environmental factors, affecting up to 10% of the female population of childbearing age, causing pain and infertility; it is characterized by the ectopic growth of endometrial tissue outside the uterine cavity. Of note, epidemiological data obtained thus far have suggested a link between endometriosis and the risk of developing CVD. The similarities observed in specific molecular and cellular pathways of endometriosis and CVD may be partially explained by a shared genetic background. The present review presents and discusses the shared genetic factors which have been reported to be associated with the development of both disorders. |
| doi_str_mv | 10.3892/ijmm.2023.5232 |
| format | Article |
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Atherosclerosis is a chronic inflammatory disease of the arterial intima and is the primary cause of coronary artery disease, peripheral vascular disease, heart attack, stroke and renal pathology. It represents a leading cause of mortality worldwide and the loss of human productivity that is marked by an altered immune response. Endometriosis is a heritable, heterogeneous, common gynecological condition influenced by multiple genetic, epigenetic and environmental factors, affecting up to 10% of the female population of childbearing age, causing pain and infertility; it is characterized by the ectopic growth of endometrial tissue outside the uterine cavity. Of note, epidemiological data obtained thus far have suggested a link between endometriosis and the risk of developing CVD. The similarities observed in specific molecular and cellular pathways of endometriosis and CVD may be partially explained by a shared genetic background. The present review presents and discusses the shared genetic factors which have been reported to be associated with the development of both disorders.</description><identifier>ISSN: 1107-3756</identifier><identifier>EISSN: 1791-244X</identifier><identifier>DOI: 10.3892/ijmm.2023.5232</identifier><identifier>PMID: 36799179</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Angiogenesis ; Atherosclerosis ; Blood circulation disorders ; Blood vessels ; Cardiovascular disease ; Cardiovascular Diseases - genetics ; Cardiovascular system ; Cell cycle ; Chronic illnesses ; Coronary Artery Disease ; Cyclin-dependent kinases ; Development and progression ; Endometriosis ; Endometriosis - complications ; Endometriosis - genetics ; Endometriosis - metabolism ; Epidemiology ; Epigenetic inheritance ; Estrogens ; Female ; Gene loci ; Genetic aspects ; Genetic engineering ; Genetic polymorphisms ; Genomes ; Genomics ; Greece ; Health aspects ; Heart ; Heart attack ; Humans ; Immune response ; Inflammation ; Kinases ; Lipids ; Menstruation ; Mortality ; Risk factors ; Uterus - pathology ; Womens health</subject><ispartof>International journal of molecular medicine, 2023-03, Vol.51 (3), p.1, Article 29</ispartof><rights>COPYRIGHT 2023 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2023</rights><rights>Copyright: © Vazgiourakis et al. 2023</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-52a502a8b21bf2d8b0b0b0530e3522f28cab8f31cf1d72851e6033fcccd82a1c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36799179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vazgiourakis, Vassilios M</creatorcontrib><creatorcontrib>Zervou, Maria I</creatorcontrib><creatorcontrib>Papageorgiou, Louis</creatorcontrib><creatorcontrib>Chaniotis, Dimitrios</creatorcontrib><creatorcontrib>Spandidos, Demetrios A</creatorcontrib><creatorcontrib>Vlachakis, Dimitrios</creatorcontrib><creatorcontrib>Eliopoulos, Elias</creatorcontrib><creatorcontrib>Goulielmos, George N</creatorcontrib><title>Association of endometriosis with cardiovascular disease: Genetic aspects (Review)</title><title>International journal of molecular medicine</title><addtitle>Int J Mol Med</addtitle><description>Cardiovascular disease (CVD) comprises a broad spectrum of pathological conditions that affect the heart or blood vessels, including sequelae that arise from damaged vasculature in other organs of the body, such as the brain, kidneys or eyes. Atherosclerosis is a chronic inflammatory disease of the arterial intima and is the primary cause of coronary artery disease, peripheral vascular disease, heart attack, stroke and renal pathology. It represents a leading cause of mortality worldwide and the loss of human productivity that is marked by an altered immune response. Endometriosis is a heritable, heterogeneous, common gynecological condition influenced by multiple genetic, epigenetic and environmental factors, affecting up to 10% of the female population of childbearing age, causing pain and infertility; it is characterized by the ectopic growth of endometrial tissue outside the uterine cavity. Of note, epidemiological data obtained thus far have suggested a link between endometriosis and the risk of developing CVD. The similarities observed in specific molecular and cellular pathways of endometriosis and CVD may be partially explained by a shared genetic background. The present review presents and discusses the shared genetic factors which have been reported to be associated with the development of both disorders.</description><subject>Angiogenesis</subject><subject>Atherosclerosis</subject><subject>Blood circulation disorders</subject><subject>Blood vessels</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Cardiovascular system</subject><subject>Cell cycle</subject><subject>Chronic illnesses</subject><subject>Coronary Artery Disease</subject><subject>Cyclin-dependent kinases</subject><subject>Development and progression</subject><subject>Endometriosis</subject><subject>Endometriosis - complications</subject><subject>Endometriosis - genetics</subject><subject>Endometriosis - metabolism</subject><subject>Epidemiology</subject><subject>Epigenetic inheritance</subject><subject>Estrogens</subject><subject>Female</subject><subject>Gene loci</subject><subject>Genetic aspects</subject><subject>Genetic engineering</subject><subject>Genetic polymorphisms</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Greece</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Heart attack</subject><subject>Humans</subject><subject>Immune response</subject><subject>Inflammation</subject><subject>Kinases</subject><subject>Lipids</subject><subject>Menstruation</subject><subject>Mortality</subject><subject>Risk factors</subject><subject>Uterus - pathology</subject><subject>Womens health</subject><issn>1107-3756</issn><issn>1791-244X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkd9rFDEQx4Mo9oe--igLvujDnslkc5v4UDiKrYWCUBR8C9nZSZvjdnMme1f875vFWlso85Aw-cyXCR_G3gm-kNrA57AehgVwkAsFEl6wQ9EaUUPT_HpZ7oK3tWzV8oAd5bzmHFRj9Gt2IJetMYU8ZFernCMGN4U4VtFXNPZxoCmFmEOubsN0U6FLfYh7l3G3canqQyaX6Ut1TiNNASuXt4RTrj5e0T7Q7ac37JV3m0xv789j9vPs64_Tb_Xl9_OL09VljY1WU63AKQ5OdyA6D73u-FxKcpIKwING12kvBXrRt6CVoCWX0iNir8EJlMfs5G_udtcN1CONU3Ibu01hcOmPjS7Ypy9juLHXcW-NaaSSpgR8uA9I8feO8mTXcZfGsrOFVovGCNMs_1PXbkM2jD6WMBxCRrtqG5BKcdMWavEMVaqnIWAcyYfSf24AU8w5kX9YXHA7q7WzWjurtbPaMvD-8Xcf8H8u5R38PaA0</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Vazgiourakis, Vassilios M</creator><creator>Zervou, Maria I</creator><creator>Papageorgiou, Louis</creator><creator>Chaniotis, Dimitrios</creator><creator>Spandidos, Demetrios A</creator><creator>Vlachakis, Dimitrios</creator><creator>Eliopoulos, Elias</creator><creator>Goulielmos, George N</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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Atherosclerosis is a chronic inflammatory disease of the arterial intima and is the primary cause of coronary artery disease, peripheral vascular disease, heart attack, stroke and renal pathology. It represents a leading cause of mortality worldwide and the loss of human productivity that is marked by an altered immune response. Endometriosis is a heritable, heterogeneous, common gynecological condition influenced by multiple genetic, epigenetic and environmental factors, affecting up to 10% of the female population of childbearing age, causing pain and infertility; it is characterized by the ectopic growth of endometrial tissue outside the uterine cavity. Of note, epidemiological data obtained thus far have suggested a link between endometriosis and the risk of developing CVD. The similarities observed in specific molecular and cellular pathways of endometriosis and CVD may be partially explained by a shared genetic background. 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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Angiogenesis Atherosclerosis Blood circulation disorders Blood vessels Cardiovascular disease Cardiovascular Diseases - genetics Cardiovascular system Cell cycle Chronic illnesses Coronary Artery Disease Cyclin-dependent kinases Development and progression Endometriosis Endometriosis - complications Endometriosis - genetics Endometriosis - metabolism Epidemiology Epigenetic inheritance Estrogens Female Gene loci Genetic aspects Genetic engineering Genetic polymorphisms Genomes Genomics Greece Health aspects Heart Heart attack Humans Immune response Inflammation Kinases Lipids Menstruation Mortality Risk factors Uterus - pathology Womens health |
| title | Association of endometriosis with cardiovascular disease: Genetic aspects (Review) |
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