Evocalcet Rescues Secondary Hyperparathyroidism-driven Cortical Porosity in CKD Male Rats

Abstract To elucidate the effect of evocalcet, a new oral calcimimetic to bone of secondary hyperparathyroidism (SHPT) with chronic kidney disease (CKD), the rats were 5/6 nephrectomized and fed on a high-phosphate diet. The treated rats were then divided into vehicle groups and evocalcet administer...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2023-02, Vol.164 (4)
Hauptverfasser:	Hasegawa, Tomoka, Tokunaga, Shin, Yamamoto, Tomomaya, Sakai, Mariko, Hongo, Hiromi, Kawata, Takehisa, Amizuka, Norio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone turnover Cell death Cortical bone Demineralization Endocrinology Glycoproteins Hyperparathyroidism Hyperparathyroidism, Secondary - etiology Kidney diseases Male Mineralization Mortality Naphthalenes Osteocytes Osteolysis Parathyroid Hormone Pit1 protein Porosity Rats Renal Insufficiency, Chronic - complications
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