The sodium channel subunit SCNN1B suppresses colorectal cancer via suppression of active c-Raf and MAPK signaling cascade

The incidence of colorectal cancer (CRC) is rising worldwide. Here, we identified SCNN1B as an outlier down-regulated in CRC and it functions as a tumor suppressor. SCNN1B mRNA and protein expression were down-regulated in primary CRC and CRC cells. In a tissue microarray cohort ( N = 153), SCNN1B...

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Veröffentlicht in:	Oncogene 2023-02, Vol.42 (8), p.601-612
Hauptverfasser:	Qian, Yun, Zhou, Lianxin, Luk, Simson Tsz Yat, Xu, Jiaying, Li, Weilin, Gou, Hongyan, Chen, Huarong, Kang, Wei, Yu, Jun, Wong, Chi Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	13/2 13/51 13/95 14 38 38/77 42 631/67/1504/1885 631/67/68 631/80/86/2368 96 96/1 96/95 Apoptosis Cell Biology Cell cycle Cell growth Cell Line, Tumor Cell migration Cell Proliferation Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology DNA microarrays Ectopic expression Epithelial Sodium Channels - metabolism Extracellular signal-regulated kinase Gene expression Gene set enrichment analysis Human Genetics Humans Internal Medicine K-Ras protein Kinases MAP kinase MAP Kinase Signaling System Medicine Medicine & Public Health Mitogen-Activated Protein Kinase Kinases - metabolism Oncology Phosphorylation Proto-Oncogene Proteins c-raf - genetics Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Raf protein Signal Transduction Sodium channels Sodium Channels - metabolism Tumor suppressor genes Tumors Xenografts
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