In vitro transcriptomic analyses reveal pathway perturbations, estrogenic activities, and potencies of data-poor BPA alternative chemicals

Since initial regulatory action in 2010 in Canada, bisphenol A (BPA) has been progressively replaced by structurally related alternative chemicals. Unfortunately, many of these chemicals are data-poor, limiting toxicological risk assessment. We used high-throughput transcriptomics to evaluate potent...

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Veröffentlicht in:	Toxicological sciences 2023-02, Vol.191 (2), p.266-275
Hauptverfasser:	Matteo, Geronimo, Leingartner, Karen, Rowan-Carroll, Andrea, Meier, Matthew, Williams, Andrew, Beal, Marc A, Gagné, Matthew, Farmahin, Reza, Wickramasuriya, Shamika, Reardon, Anthony J F, Barton-Maclaren, Tara, Christopher Corton, J, Yauk, Carole L, Atlas, Ella
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzhydryl Compounds - toxicity Endocrine Toxicology Estrogen Receptor alpha - metabolism Estrogens - adverse effects Estrogens - pharmacology Estrone Gene Expression Profiling Humans MCF-7 Cells Transcriptome
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