Granulosa cells from immature follicles exhibit restricted glycolysis and reduced energy production: a dominant problem in polycystic ovary syndrome

Purpose We hypothesized that immature oocytes are associated with impaired energy production in surrounding granulosa cells (GCs) in polycystic ovary syndrome (PCOS). Thus, this study investigated mitochondrial function, determined expression of glycolytic regulatory enzymes, and measured ATP levels...

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Veröffentlicht in:	Journal of assisted reproduction and genetics 2023-02, Vol.40 (2), p.343-359
Hauptverfasser:	Mazloomi, Sahar, Farimani, Marzieh Sanoee, Tavilani, Heidar, Karimi, Jamshid, Amiri, Iraj, Abbasi, Ebrahim, Khodadadi, Iraj
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Antioxidants - metabolism Catalase Enzymes Female Follicles Gene expression Glycolysis Granulosa cells Granulosa Cells - metabolism Gynecology Hexokinase Human Genetics Humans Kinases Medicine Medicine & Public Health Membrane potential Mitochondria Oocytes Ovaries Phosphofructokinase Phosphofructokinases - genetics Phosphofructokinases - metabolism Polycystic ovary syndrome Polycystic Ovary Syndrome - genetics Polycystic Ovary Syndrome - metabolism Pregnancy Pyruvate kinase Pyruvic acid Reactive oxygen species Reactive Oxygen Species - metabolism Reproductive Medicine Reproductive Physiology and Disease Superoxide dismutase
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