Association of lumbar vertebral bone marrow and paraspinal muscle fat composition with intervertebral disc degeneration: 3T quantitative MRI findings from the population-based KORA study
Objective To assess the association of lumbar bone marrow adipose tissue fat fraction (BMAT-FF) and paraspinal muscle proton density fat fraction (PDFF) and their interplay with intervertebral disc degeneration (IVDD). Methods In this retrospective cross-sectional study based on a prospective popula...
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| Veröffentlicht in: | European radiology 2023-03, Vol.33 (3), p.1501-1512 |
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| creator | Jung, Matthias Rospleszcz, Susanne Löffler, Maximilian T. Walter, Sven S. Maurer, Elke Jungmann, Pia M. Peters, Annette Nattenmüller, Johanna Schlett, Christopher L. Bamberg, Fabian Kiefer, Lena S. Diallo, Thierno D. |
| description | Objective
To assess the association of lumbar bone marrow adipose tissue fat fraction (BMAT-FF) and paraspinal muscle proton density fat fraction (PDFF) and their interplay with intervertebral disc degeneration (IVDD).
Methods
In this retrospective cross-sectional study based on a prospective population-based cohort, BMAT-FF and PDFF of asymptomatic individuals were calculated based on 3T-MRI dual-echo and multi-echo Dixon VIBE sequences. IVDD was assessed at motion segments L1 to L5 and dichotomized based on Pfirrmann grade ≥ 4 and/or presence of other severe degenerative changes or spinal abnormalities at least at one segment. Pearson’s correlation coefficients were calculated for BMAT-FF and PDFF. Univariable and multivariable logistic regression models for IVDD were calculated.
Results
Among 335 participants (mean age: 56.2 ± 9.0 years, 43.3% female), the average BMI was 27.7 ± 4.5 kg/m
2
and the prevalence of IVDD was high (69.9%). BMAT-FF and PDFF were significantly correlated (
r
= 0.31–0.34;
p
< 0.001). The risk for IVDD increased with higher PDFF (OR = 1.45; CI 1.03, 2.04) and BMAT-FF (OR = 1.56; CI 1.16, 2.11). Pairwise combinations of PDFF and BMAT-FF quartiles revealed a lower risk for IVDD in individuals in the lowest BMAT-FF and PDFF quartile (OR = 0.21; CI 0.1, 0.48). Individuals in the highest BMAT-FF and PDFF quartile showed an increased risk for IVDD (OR = 5.12; CI 1.17, 22.34)
Conclusion
Lumbar BMAT-FF and paraspinal muscle PDFF are correlated and represent both independent and additive risk factors for IVDD. Quantitative MRI measurements of paraspinal myosteatosis and vertebral bone marrow fatty infiltration may serve as imaging biomarkers to assess the individual risk for IVDD.
Key Points
• Fat composition of the lumbar vertebral bone marrow is positively correlated with paraspinal skeletal muscle fat
.
• Higher fat-fractions of lumbar vertebral bone marrow and paraspinal muscle are both independent as well as additive risk factors for intervertebral disc degeneration
.
• Quantitative magnetic resonance imaging measurements of bone marrow and paraspinal muscle may serve as imaging biomarkers for intervertebral disc degeneration
. |
| doi_str_mv | 10.1007/s00330-022-09140-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9935727</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2777162702</sourcerecordid><originalsourceid>FETCH-LOGICAL-c404t-fbb39e4c64d08b4d6008a5b4da4b0bcf679bad7871284630b7312d84cb1a02333</originalsourceid><addsrcrecordid>eNp9kstu1DAUhiMEohd4ARbIEhs2gePLxAkLpFFFoaKoUlXWlm-ZcZXYqe1M1Vfj6fDMlLawYOUjn-_856K_qt5g-IAB-McEQCnUQEgNHWZQs2fVIWaU1Bha9vxJfFAdpXQNsMX4y-qANoThjsBh9WuZUtBOZhc8Cj0a5lHJiDY2ZquiHJAK3qJRxhhukfQGTTLKNDlfUuOc9GBRLzPSYZxCcjuVW5fXyPls46OKcUkjY1fW27jr9QnRK3QzS59dLh8bi35cnqHeeeP8KqE-hhHltUVTmOZhV1ErmaxB3y8ulyjl2dy9ql70ckj29f17XP08_XJ18q0-v_h6drI8rzUDluteKdpZphtmoFXMNACtXJRAMgVK9w3vlDS85Zi0rKGgOMXEtEwrLIFQSo-rz3vdaVajNdr6XFYSU3TlLHciSCf-zni3FquwEV1HF5zwIvD-XiCGm9mmLMZyDjsM0tswJ0E4WRBYYEYK-u4f9DrMsRx7S3GOG8JhS5E9pWNIKdr-YRgMYmsNsbeGKNYQO2sIVorePl3joeSPFwpA90AqKb-y8bH3f2R_Aw1QyTA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2777162702</pqid></control><display><type>article</type><title>Association of lumbar vertebral bone marrow and paraspinal muscle fat composition with intervertebral disc degeneration: 3T quantitative MRI findings from the population-based KORA study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Jung, Matthias ; Rospleszcz, Susanne ; Löffler, Maximilian T. ; Walter, Sven S. ; Maurer, Elke ; Jungmann, Pia M. ; Peters, Annette ; Nattenmüller, Johanna ; Schlett, Christopher L. ; Bamberg, Fabian ; Kiefer, Lena S. ; Diallo, Thierno D.</creator><creatorcontrib>Jung, Matthias ; Rospleszcz, Susanne ; Löffler, Maximilian T. ; Walter, Sven S. ; Maurer, Elke ; Jungmann, Pia M. ; Peters, Annette ; Nattenmüller, Johanna ; Schlett, Christopher L. ; Bamberg, Fabian ; Kiefer, Lena S. ; Diallo, Thierno D.</creatorcontrib><description>Objective
To assess the association of lumbar bone marrow adipose tissue fat fraction (BMAT-FF) and paraspinal muscle proton density fat fraction (PDFF) and their interplay with intervertebral disc degeneration (IVDD).
Methods
In this retrospective cross-sectional study based on a prospective population-based cohort, BMAT-FF and PDFF of asymptomatic individuals were calculated based on 3T-MRI dual-echo and multi-echo Dixon VIBE sequences. IVDD was assessed at motion segments L1 to L5 and dichotomized based on Pfirrmann grade ≥ 4 and/or presence of other severe degenerative changes or spinal abnormalities at least at one segment. Pearson’s correlation coefficients were calculated for BMAT-FF and PDFF. Univariable and multivariable logistic regression models for IVDD were calculated.
Results
Among 335 participants (mean age: 56.2 ± 9.0 years, 43.3% female), the average BMI was 27.7 ± 4.5 kg/m
2
and the prevalence of IVDD was high (69.9%). BMAT-FF and PDFF were significantly correlated (
r
= 0.31–0.34;
p
< 0.001). The risk for IVDD increased with higher PDFF (OR = 1.45; CI 1.03, 2.04) and BMAT-FF (OR = 1.56; CI 1.16, 2.11). Pairwise combinations of PDFF and BMAT-FF quartiles revealed a lower risk for IVDD in individuals in the lowest BMAT-FF and PDFF quartile (OR = 0.21; CI 0.1, 0.48). Individuals in the highest BMAT-FF and PDFF quartile showed an increased risk for IVDD (OR = 5.12; CI 1.17, 22.34)
Conclusion
Lumbar BMAT-FF and paraspinal muscle PDFF are correlated and represent both independent and additive risk factors for IVDD. Quantitative MRI measurements of paraspinal myosteatosis and vertebral bone marrow fatty infiltration may serve as imaging biomarkers to assess the individual risk for IVDD.
Key Points
• Fat composition of the lumbar vertebral bone marrow is positively correlated with paraspinal skeletal muscle fat
.
• Higher fat-fractions of lumbar vertebral bone marrow and paraspinal muscle are both independent as well as additive risk factors for intervertebral disc degeneration
.
• Quantitative magnetic resonance imaging measurements of bone marrow and paraspinal muscle may serve as imaging biomarkers for intervertebral disc degeneration
.</description><identifier>ISSN: 1432-1084</identifier><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-022-09140-4</identifier><identifier>PMID: 36241920</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abnormalities ; Adipose tissue ; Adipose Tissue - diagnostic imaging ; Aged ; Biomarkers ; Bone composition ; Bone imaging ; Bone marrow ; Bone Marrow - diagnostic imaging ; Composition ; Correlation coefficient ; Correlation coefficients ; Cross-Sectional Studies ; Degeneration ; Degenerative disc disease ; Diagnostic Radiology ; Female ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Intervertebral Disc ; Intervertebral Disc Degeneration - diagnostic imaging ; Intervertebral discs ; Lumbar Vertebrae - diagnostic imaging ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Middle Aged ; Muscles ; Musculoskeletal ; Neuroradiology ; Paraspinal Muscles - diagnostic imaging ; Population studies ; Population-based studies ; Prospective Studies ; Proton density (concentration) ; Protons ; Quartiles ; Radiology ; Regression analysis ; Regression models ; Retrospective Studies ; Risk factors ; Segments ; Skeletal muscle ; Ultrasound ; Vertebrae</subject><ispartof>European radiology, 2023-03, Vol.33 (3), p.1501-1512</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-fbb39e4c64d08b4d6008a5b4da4b0bcf679bad7871284630b7312d84cb1a02333</citedby><cites>FETCH-LOGICAL-c404t-fbb39e4c64d08b4d6008a5b4da4b0bcf679bad7871284630b7312d84cb1a02333</cites><orcidid>0000-0002-1124-4284</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-022-09140-4$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-022-09140-4$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36241920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, Matthias</creatorcontrib><creatorcontrib>Rospleszcz, Susanne</creatorcontrib><creatorcontrib>Löffler, Maximilian T.</creatorcontrib><creatorcontrib>Walter, Sven S.</creatorcontrib><creatorcontrib>Maurer, Elke</creatorcontrib><creatorcontrib>Jungmann, Pia M.</creatorcontrib><creatorcontrib>Peters, Annette</creatorcontrib><creatorcontrib>Nattenmüller, Johanna</creatorcontrib><creatorcontrib>Schlett, Christopher L.</creatorcontrib><creatorcontrib>Bamberg, Fabian</creatorcontrib><creatorcontrib>Kiefer, Lena S.</creatorcontrib><creatorcontrib>Diallo, Thierno D.</creatorcontrib><title>Association of lumbar vertebral bone marrow and paraspinal muscle fat composition with intervertebral disc degeneration: 3T quantitative MRI findings from the population-based KORA study</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objective
To assess the association of lumbar bone marrow adipose tissue fat fraction (BMAT-FF) and paraspinal muscle proton density fat fraction (PDFF) and their interplay with intervertebral disc degeneration (IVDD).
Methods
In this retrospective cross-sectional study based on a prospective population-based cohort, BMAT-FF and PDFF of asymptomatic individuals were calculated based on 3T-MRI dual-echo and multi-echo Dixon VIBE sequences. IVDD was assessed at motion segments L1 to L5 and dichotomized based on Pfirrmann grade ≥ 4 and/or presence of other severe degenerative changes or spinal abnormalities at least at one segment. Pearson’s correlation coefficients were calculated for BMAT-FF and PDFF. Univariable and multivariable logistic regression models for IVDD were calculated.
Results
Among 335 participants (mean age: 56.2 ± 9.0 years, 43.3% female), the average BMI was 27.7 ± 4.5 kg/m
2
and the prevalence of IVDD was high (69.9%). BMAT-FF and PDFF were significantly correlated (
r
= 0.31–0.34;
p
< 0.001). The risk for IVDD increased with higher PDFF (OR = 1.45; CI 1.03, 2.04) and BMAT-FF (OR = 1.56; CI 1.16, 2.11). Pairwise combinations of PDFF and BMAT-FF quartiles revealed a lower risk for IVDD in individuals in the lowest BMAT-FF and PDFF quartile (OR = 0.21; CI 0.1, 0.48). Individuals in the highest BMAT-FF and PDFF quartile showed an increased risk for IVDD (OR = 5.12; CI 1.17, 22.34)
Conclusion
Lumbar BMAT-FF and paraspinal muscle PDFF are correlated and represent both independent and additive risk factors for IVDD. Quantitative MRI measurements of paraspinal myosteatosis and vertebral bone marrow fatty infiltration may serve as imaging biomarkers to assess the individual risk for IVDD.
Key Points
• Fat composition of the lumbar vertebral bone marrow is positively correlated with paraspinal skeletal muscle fat
.
• Higher fat-fractions of lumbar vertebral bone marrow and paraspinal muscle are both independent as well as additive risk factors for intervertebral disc degeneration
.
• Quantitative magnetic resonance imaging measurements of bone marrow and paraspinal muscle may serve as imaging biomarkers for intervertebral disc degeneration
.</description><subject>Abnormalities</subject><subject>Adipose tissue</subject><subject>Adipose Tissue - diagnostic imaging</subject><subject>Aged</subject><subject>Biomarkers</subject><subject>Bone composition</subject><subject>Bone imaging</subject><subject>Bone marrow</subject><subject>Bone Marrow - diagnostic imaging</subject><subject>Composition</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Cross-Sectional Studies</subject><subject>Degeneration</subject><subject>Degenerative disc disease</subject><subject>Diagnostic Radiology</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Intervertebral Disc</subject><subject>Intervertebral Disc Degeneration - diagnostic imaging</subject><subject>Intervertebral discs</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Muscles</subject><subject>Musculoskeletal</subject><subject>Neuroradiology</subject><subject>Paraspinal Muscles - diagnostic imaging</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Prospective Studies</subject><subject>Proton density (concentration)</subject><subject>Protons</subject><subject>Quartiles</subject><subject>Radiology</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Segments</subject><subject>Skeletal muscle</subject><subject>Ultrasound</subject><subject>Vertebrae</subject><issn>1432-1084</issn><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kstu1DAUhiMEohd4ARbIEhs2gePLxAkLpFFFoaKoUlXWlm-ZcZXYqe1M1Vfj6fDMlLawYOUjn-_856K_qt5g-IAB-McEQCnUQEgNHWZQs2fVIWaU1Bha9vxJfFAdpXQNsMX4y-qANoThjsBh9WuZUtBOZhc8Cj0a5lHJiDY2ZquiHJAK3qJRxhhukfQGTTLKNDlfUuOc9GBRLzPSYZxCcjuVW5fXyPls46OKcUkjY1fW27jr9QnRK3QzS59dLh8bi35cnqHeeeP8KqE-hhHltUVTmOZhV1ErmaxB3y8ulyjl2dy9ql70ckj29f17XP08_XJ18q0-v_h6drI8rzUDluteKdpZphtmoFXMNACtXJRAMgVK9w3vlDS85Zi0rKGgOMXEtEwrLIFQSo-rz3vdaVajNdr6XFYSU3TlLHciSCf-zni3FquwEV1HF5zwIvD-XiCGm9mmLMZyDjsM0tswJ0E4WRBYYEYK-u4f9DrMsRx7S3GOG8JhS5E9pWNIKdr-YRgMYmsNsbeGKNYQO2sIVorePl3joeSPFwpA90AqKb-y8bH3f2R_Aw1QyTA</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Jung, Matthias</creator><creator>Rospleszcz, Susanne</creator><creator>Löffler, Maximilian T.</creator><creator>Walter, Sven S.</creator><creator>Maurer, Elke</creator><creator>Jungmann, Pia M.</creator><creator>Peters, Annette</creator><creator>Nattenmüller, Johanna</creator><creator>Schlett, Christopher L.</creator><creator>Bamberg, Fabian</creator><creator>Kiefer, Lena S.</creator><creator>Diallo, Thierno D.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1124-4284</orcidid></search><sort><creationdate>20230301</creationdate><title>Association of lumbar vertebral bone marrow and paraspinal muscle fat composition with intervertebral disc degeneration: 3T quantitative MRI findings from the population-based KORA study</title><author>Jung, Matthias ; Rospleszcz, Susanne ; Löffler, Maximilian T. ; Walter, Sven S. ; Maurer, Elke ; Jungmann, Pia M. ; Peters, Annette ; Nattenmüller, Johanna ; Schlett, Christopher L. ; Bamberg, Fabian ; Kiefer, Lena S. ; Diallo, Thierno D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-fbb39e4c64d08b4d6008a5b4da4b0bcf679bad7871284630b7312d84cb1a02333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abnormalities</topic><topic>Adipose tissue</topic><topic>Adipose Tissue - diagnostic imaging</topic><topic>Aged</topic><topic>Biomarkers</topic><topic>Bone composition</topic><topic>Bone imaging</topic><topic>Bone marrow</topic><topic>Bone Marrow - diagnostic imaging</topic><topic>Composition</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>Cross-Sectional Studies</topic><topic>Degeneration</topic><topic>Degenerative disc disease</topic><topic>Diagnostic Radiology</topic><topic>Female</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Intervertebral Disc</topic><topic>Intervertebral Disc Degeneration - diagnostic imaging</topic><topic>Intervertebral discs</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Muscles</topic><topic>Musculoskeletal</topic><topic>Neuroradiology</topic><topic>Paraspinal Muscles - diagnostic imaging</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Prospective Studies</topic><topic>Proton density (concentration)</topic><topic>Protons</topic><topic>Quartiles</topic><topic>Radiology</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Segments</topic><topic>Skeletal muscle</topic><topic>Ultrasound</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Matthias</creatorcontrib><creatorcontrib>Rospleszcz, Susanne</creatorcontrib><creatorcontrib>Löffler, Maximilian T.</creatorcontrib><creatorcontrib>Walter, Sven S.</creatorcontrib><creatorcontrib>Maurer, Elke</creatorcontrib><creatorcontrib>Jungmann, Pia M.</creatorcontrib><creatorcontrib>Peters, Annette</creatorcontrib><creatorcontrib>Nattenmüller, Johanna</creatorcontrib><creatorcontrib>Schlett, Christopher L.</creatorcontrib><creatorcontrib>Bamberg, Fabian</creatorcontrib><creatorcontrib>Kiefer, Lena S.</creatorcontrib><creatorcontrib>Diallo, Thierno D.</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Matthias</au><au>Rospleszcz, Susanne</au><au>Löffler, Maximilian T.</au><au>Walter, Sven S.</au><au>Maurer, Elke</au><au>Jungmann, Pia M.</au><au>Peters, Annette</au><au>Nattenmüller, Johanna</au><au>Schlett, Christopher L.</au><au>Bamberg, Fabian</au><au>Kiefer, Lena S.</au><au>Diallo, Thierno D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of lumbar vertebral bone marrow and paraspinal muscle fat composition with intervertebral disc degeneration: 3T quantitative MRI findings from the population-based KORA study</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>33</volume><issue>3</issue><spage>1501</spage><epage>1512</epage><pages>1501-1512</pages><issn>1432-1084</issn><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objective
To assess the association of lumbar bone marrow adipose tissue fat fraction (BMAT-FF) and paraspinal muscle proton density fat fraction (PDFF) and their interplay with intervertebral disc degeneration (IVDD).
Methods
In this retrospective cross-sectional study based on a prospective population-based cohort, BMAT-FF and PDFF of asymptomatic individuals were calculated based on 3T-MRI dual-echo and multi-echo Dixon VIBE sequences. IVDD was assessed at motion segments L1 to L5 and dichotomized based on Pfirrmann grade ≥ 4 and/or presence of other severe degenerative changes or spinal abnormalities at least at one segment. Pearson’s correlation coefficients were calculated for BMAT-FF and PDFF. Univariable and multivariable logistic regression models for IVDD were calculated.
Results
Among 335 participants (mean age: 56.2 ± 9.0 years, 43.3% female), the average BMI was 27.7 ± 4.5 kg/m
2
and the prevalence of IVDD was high (69.9%). BMAT-FF and PDFF were significantly correlated (
r
= 0.31–0.34;
p
< 0.001). The risk for IVDD increased with higher PDFF (OR = 1.45; CI 1.03, 2.04) and BMAT-FF (OR = 1.56; CI 1.16, 2.11). Pairwise combinations of PDFF and BMAT-FF quartiles revealed a lower risk for IVDD in individuals in the lowest BMAT-FF and PDFF quartile (OR = 0.21; CI 0.1, 0.48). Individuals in the highest BMAT-FF and PDFF quartile showed an increased risk for IVDD (OR = 5.12; CI 1.17, 22.34)
Conclusion
Lumbar BMAT-FF and paraspinal muscle PDFF are correlated and represent both independent and additive risk factors for IVDD. Quantitative MRI measurements of paraspinal myosteatosis and vertebral bone marrow fatty infiltration may serve as imaging biomarkers to assess the individual risk for IVDD.
Key Points
• Fat composition of the lumbar vertebral bone marrow is positively correlated with paraspinal skeletal muscle fat
.
• Higher fat-fractions of lumbar vertebral bone marrow and paraspinal muscle are both independent as well as additive risk factors for intervertebral disc degeneration
.
• Quantitative magnetic resonance imaging measurements of bone marrow and paraspinal muscle may serve as imaging biomarkers for intervertebral disc degeneration
.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36241920</pmid><doi>10.1007/s00330-022-09140-4</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-1124-4284</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-1084 |
| ispartof | European radiology, 2023-03, Vol.33 (3), p.1501-1512 |
| issn | 1432-1084 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9935727 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Abnormalities Adipose tissue Adipose Tissue - diagnostic imaging Aged Biomarkers Bone composition Bone imaging Bone marrow Bone Marrow - diagnostic imaging Composition Correlation coefficient Correlation coefficients Cross-Sectional Studies Degeneration Degenerative disc disease Diagnostic Radiology Female Humans Imaging Internal Medicine Interventional Radiology Intervertebral Disc Intervertebral Disc Degeneration - diagnostic imaging Intervertebral discs Lumbar Vertebrae - diagnostic imaging Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical imaging Medicine Medicine & Public Health Middle Aged Muscles Musculoskeletal Neuroradiology Paraspinal Muscles - diagnostic imaging Population studies Population-based studies Prospective Studies Proton density (concentration) Protons Quartiles Radiology Regression analysis Regression models Retrospective Studies Risk factors Segments Skeletal muscle Ultrasound Vertebrae |
| title | Association of lumbar vertebral bone marrow and paraspinal muscle fat composition with intervertebral disc degeneration: 3T quantitative MRI findings from the population-based KORA study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T03%3A46%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20lumbar%20vertebral%20bone%20marrow%20and%20paraspinal%20muscle%20fat%20composition%20with%20intervertebral%20disc%20degeneration:%203T%20quantitative%20MRI%20findings%20from%20the%20population-based%20KORA%20study&rft.jtitle=European%20radiology&rft.au=Jung,%20Matthias&rft.date=2023-03-01&rft.volume=33&rft.issue=3&rft.spage=1501&rft.epage=1512&rft.pages=1501-1512&rft.issn=1432-1084&rft.eissn=1432-1084&rft_id=info:doi/10.1007/s00330-022-09140-4&rft_dat=%3Cproquest_pubme%3E2777162702%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2777162702&rft_id=info:pmid/36241920&rfr_iscdi=true |