Development of a Universal Second-Tier Newborn Screening LC–MS/MS Method for Amino Acids, Lysophosphatidylcholines, and Organic Acids

First-tier MS-based newborn screening by flow injection analysis can have high presumptive positive rates, often due to isomeric/isobaric compounds or poor biomarker specificity. These presumptive positive samples can be analyzed by second-tier screening assays employing separations such as liquid c...

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Veröffentlicht in:	Analytical chemistry (Washington) 2023-02, Vol.95 (6), p.3187-3194
Hauptverfasser:	Kilgore, Matthew B., Platis, Dimitrios, Lim, Timothy, Isenberg, Samantha, Pickens, C. Austin, Cuthbert, Carla, Petritis, Konstantinos
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-CoA dehydrogenase Adrenoleukodystrophy Amino Acids Antifibrinolytic Agents Biomarkers Chemistry Chromatography, Liquid Column chromatography Flow injection analysis Guanidinoacetate N-methyltransferase Homocystinuria Humans Infant, Newborn INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY Liquid chromatography Lysophosphatidylcholines Maple syrup Maple syrup urine disease Mass spectrometry Mass spectroscopy Methyltransferase Multiplexing Neonatal Screening - methods Organic acids Organic Chemicals Propionic Acidemia Public health Screening Syrup Tandem Mass Spectrometry - methods
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