NAD+-Consuming Enzymes in Stem Cell Homeostasis
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme used in redox reactions, energy metabolism, and mitochondrial biogenesis. NAD+ is also required as a cofactor by nonredox NAD+-dependent enzymes. Hundreds of enzymes that consume NAD+ have been identified. The NAD+-consuming enzymes are involved...
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| Veröffentlicht in: | Oxidative medicine and cellular longevity 2023, Vol.2023, p.4985726-11 |
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| container_title | Oxidative medicine and cellular longevity |
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| creator | Ji, Xiuna Zheng, Mingyue Yu, Tao Kang, Jie Fan, Tingjun Xu, Bin |
| description | Nicotinamide adenine dinucleotide (NAD+) is a coenzyme used in redox reactions, energy metabolism, and mitochondrial biogenesis. NAD+ is also required as a cofactor by nonredox NAD+-dependent enzymes. Hundreds of enzymes that consume NAD+ have been identified. The NAD+-consuming enzymes are involved in a variety of cellular processes such as signal transduction, DNA repair, cellular senescence, and stem cell (SC) homeostasis. In this review, we discussed how different types of NAD+-consuming enzymes regulate SC functions and summarized current research on the roles of the NAD+ consumers in SC homeostasis. We hope to provide a more global and integrative insight to the mechanism and intervention of SC homeostasis via the regulation of the NAD+-consuming enzymes. |
| doi_str_mv | 10.1155/2023/4985726 |
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NAD+ is also required as a cofactor by nonredox NAD+-dependent enzymes. Hundreds of enzymes that consume NAD+ have been identified. The NAD+-consuming enzymes are involved in a variety of cellular processes such as signal transduction, DNA repair, cellular senescence, and stem cell (SC) homeostasis. In this review, we discussed how different types of NAD+-consuming enzymes regulate SC functions and summarized current research on the roles of the NAD+ consumers in SC homeostasis. We hope to provide a more global and integrative insight to the mechanism and intervention of SC homeostasis via the regulation of the NAD+-consuming enzymes.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2023/4985726</identifier><identifier>PMID: 36819783</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Adenosine diphosphate ; Aging ; Antioxidants ; Autophagy ; Cancer ; Cell cycle ; Circadian rhythm ; Dehydrogenases ; DNA methylation ; DNA repair ; Energy Metabolism ; Enzymes ; Epigenetics ; Genes ; Homeostasis ; Metabolism ; NAD - metabolism ; Oxidation-Reduction ; Oxidative stress ; Proteins ; Review ; Roles ; Senescence ; Signal Transduction ; Stem cells</subject><ispartof>Oxidative medicine and cellular longevity, 2023, Vol.2023, p.4985726-11</ispartof><rights>Copyright © 2023 Xiuna Ji et al.</rights><rights>Copyright © 2023 Xiuna Ji et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2023 Xiuna Ji et al. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3636-2927a57eada95c6c1a874b9ba7fd948a8a8c9cd689199ee09561fa9ffc05c05d3</citedby><cites>FETCH-LOGICAL-c3636-2927a57eada95c6c1a874b9ba7fd948a8a8c9cd689199ee09561fa9ffc05c05d3</cites><orcidid>0000-0003-0878-1094</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931471/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931471/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36819783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Alexander, Ivanov</contributor><contributor>Ivanov Alexander</contributor><creatorcontrib>Ji, Xiuna</creatorcontrib><creatorcontrib>Zheng, Mingyue</creatorcontrib><creatorcontrib>Yu, Tao</creatorcontrib><creatorcontrib>Kang, Jie</creatorcontrib><creatorcontrib>Fan, Tingjun</creatorcontrib><creatorcontrib>Xu, Bin</creatorcontrib><title>NAD+-Consuming Enzymes in Stem Cell Homeostasis</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Nicotinamide adenine dinucleotide (NAD+) is a coenzyme used in redox reactions, energy metabolism, and mitochondrial biogenesis. 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We hope to provide a more global and integrative insight to the mechanism and intervention of SC homeostasis via the regulation of the NAD+-consuming enzymes.</description><subject>Adenosine diphosphate</subject><subject>Aging</subject><subject>Antioxidants</subject><subject>Autophagy</subject><subject>Cancer</subject><subject>Cell cycle</subject><subject>Circadian rhythm</subject><subject>Dehydrogenases</subject><subject>DNA methylation</subject><subject>DNA repair</subject><subject>Energy Metabolism</subject><subject>Enzymes</subject><subject>Epigenetics</subject><subject>Genes</subject><subject>Homeostasis</subject><subject>Metabolism</subject><subject>NAD - metabolism</subject><subject>Oxidation-Reduction</subject><subject>Oxidative stress</subject><subject>Proteins</subject><subject>Review</subject><subject>Roles</subject><subject>Senescence</subject><subject>Signal Transduction</subject><subject>Stem cells</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc9LwzAcxYMobk5vnqXgRZh1-dE2_V6EMacTRA_qOWRpumWsyWxWZf71ZmwO9SD5QgLfD4-89xA6JfiKkDTtUUxZL4E85TTbQ20CCY0xQLK_e2PcQkfezzDOGE3IIWqxLCfAc9ZGvcf-TTceOOubythJNLSfq0r7yNjoeamraKDn82jkKu38Unrjj9FBKeden2zvDnq9Hb4MRvHD0939oP8QK5axLKZAuUy5loWEVGWKyJwnYxhLXhaQ5DIcBarIciAAWmNIM1JKKEuF0zAF66Drje6iGVe6UNouazkXi9pUsl4JJ434vbFmKibuXQAwknASBC62ArV7a7Rfisp4FdxIq13jBeUcWJKnIb0OOv-DzlxT22BvTXGgLA9ZddDlhlK1877W5e4zBIt1E2LdhNg2EfCznwZ28Hf0AehugKmxhfww_8t9ARXcjyE</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Ji, Xiuna</creator><creator>Zheng, Mingyue</creator><creator>Yu, Tao</creator><creator>Kang, Jie</creator><creator>Fan, Tingjun</creator><creator>Xu, Bin</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0878-1094</orcidid></search><sort><creationdate>2023</creationdate><title>NAD+-Consuming Enzymes in Stem Cell Homeostasis</title><author>Ji, Xiuna ; Zheng, Mingyue ; Yu, Tao ; Kang, Jie ; Fan, Tingjun ; Xu, Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3636-2927a57eada95c6c1a874b9ba7fd948a8a8c9cd689199ee09561fa9ffc05c05d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adenosine diphosphate</topic><topic>Aging</topic><topic>Antioxidants</topic><topic>Autophagy</topic><topic>Cancer</topic><topic>Cell cycle</topic><topic>Circadian rhythm</topic><topic>Dehydrogenases</topic><topic>DNA methylation</topic><topic>DNA repair</topic><topic>Energy Metabolism</topic><topic>Enzymes</topic><topic>Epigenetics</topic><topic>Genes</topic><topic>Homeostasis</topic><topic>Metabolism</topic><topic>NAD - metabolism</topic><topic>Oxidation-Reduction</topic><topic>Oxidative stress</topic><topic>Proteins</topic><topic>Review</topic><topic>Roles</topic><topic>Senescence</topic><topic>Signal Transduction</topic><topic>Stem cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ji, Xiuna</creatorcontrib><creatorcontrib>Zheng, Mingyue</creatorcontrib><creatorcontrib>Yu, Tao</creatorcontrib><creatorcontrib>Kang, Jie</creatorcontrib><creatorcontrib>Fan, Tingjun</creatorcontrib><creatorcontrib>Xu, Bin</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ji, Xiuna</au><au>Zheng, Mingyue</au><au>Yu, Tao</au><au>Kang, Jie</au><au>Fan, Tingjun</au><au>Xu, Bin</au><au>Alexander, Ivanov</au><au>Ivanov Alexander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NAD+-Consuming Enzymes in Stem Cell Homeostasis</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2023</date><risdate>2023</risdate><volume>2023</volume><spage>4985726</spage><epage>11</epage><pages>4985726-11</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Nicotinamide adenine dinucleotide (NAD+) is a coenzyme used in redox reactions, energy metabolism, and mitochondrial biogenesis. NAD+ is also required as a cofactor by nonredox NAD+-dependent enzymes. Hundreds of enzymes that consume NAD+ have been identified. The NAD+-consuming enzymes are involved in a variety of cellular processes such as signal transduction, DNA repair, cellular senescence, and stem cell (SC) homeostasis. In this review, we discussed how different types of NAD+-consuming enzymes regulate SC functions and summarized current research on the roles of the NAD+ consumers in SC homeostasis. We hope to provide a more global and integrative insight to the mechanism and intervention of SC homeostasis via the regulation of the NAD+-consuming enzymes.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>36819783</pmid><doi>10.1155/2023/4985726</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-0878-1094</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; PubMed Central Open Access; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adenosine diphosphate Aging Antioxidants Autophagy Cancer Cell cycle Circadian rhythm Dehydrogenases DNA methylation DNA repair Energy Metabolism Enzymes Epigenetics Genes Homeostasis Metabolism NAD - metabolism Oxidation-Reduction Oxidative stress Proteins Review Roles Senescence Signal Transduction Stem cells |
| title | NAD+-Consuming Enzymes in Stem Cell Homeostasis |
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