Vascular endothelial growth factor A is a potential prognostic biomarker and correlates with immune cell infiltration in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer‐related deaths among cancer patients. Vascular endothelial growth factor A (VEGFA) is involved in regulating biological processes, such as angiogenesis and vascular permeability, and is very closely related to the pathogenesis of v...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2023-02, Vol.27 (4), p.538-552 |
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| creator | Qi, Yuchen Song, Yinghui Cai, Mengting Li, Jianwen Yu, Zhangtao Li, Yuhang Huang, Junkai Jiang, Yu Peng, Chuang Jiang, Bo Liu, Sulai |
| description | Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer‐related deaths among cancer patients. Vascular endothelial growth factor A (VEGFA) is involved in regulating biological processes, such as angiogenesis and vascular permeability, and is very closely related to the pathogenesis of various tumours, especially vascular‐rich, solid tumours. Clinical data of patients with HCC and other tumours were analysed through public databases, such as the TCGA database, Gene Expression Omnibus database, Human Protein Atlas database, STRING, Tumour Immune Estimation Resource and Kaplan–Meier Plotter. The tumour tissues and adjacent normal tissues of patients with HCC from Hunan Provincial People's Hospital were collected to verify the expression of VEGFA by immunohistochemistry, immunofluorescence, Western blotting and qPCR. VEGFA expression is elevated in multiple tumour types and correlates with the prognosis of tumour patients. VEGFA is involved in regulating the tumour microenvironment and immune cell function in tumour development. Inhibition of VEGFA reduces proliferation, invasion, and migration and promotes apoptosis in HCC cells. VEGFA is a potential predictive biomarker for the diagnosis and prognosis of HCC. |
| doi_str_mv | 10.1111/jcmm.17678 |
| format | Article |
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Vascular endothelial growth factor A (VEGFA) is involved in regulating biological processes, such as angiogenesis and vascular permeability, and is very closely related to the pathogenesis of various tumours, especially vascular‐rich, solid tumours. Clinical data of patients with HCC and other tumours were analysed through public databases, such as the TCGA database, Gene Expression Omnibus database, Human Protein Atlas database, STRING, Tumour Immune Estimation Resource and Kaplan–Meier Plotter. The tumour tissues and adjacent normal tissues of patients with HCC from Hunan Provincial People's Hospital were collected to verify the expression of VEGFA by immunohistochemistry, immunofluorescence, Western blotting and qPCR. VEGFA expression is elevated in multiple tumour types and correlates with the prognosis of tumour patients. VEGFA is involved in regulating the tumour microenvironment and immune cell function in tumour development. Inhibition of VEGFA reduces proliferation, invasion, and migration and promotes apoptosis in HCC cells. VEGFA is a potential predictive biomarker for the diagnosis and prognosis of HCC.</description><identifier>ISSN: 1582-1838</identifier><identifier>ISSN: 1582-4934</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.17678</identifier><identifier>PMID: 36729917</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Angiogenesis ; Antibodies ; Apoptosis ; Biomarkers ; Biomarkers, Tumor - genetics ; Carcinoma, Hepatocellular - pathology ; Cell Line, Tumor ; Cell Movement - genetics ; Cell proliferation ; Cell Proliferation - genetics ; Cells ; Gene expression ; Genomes ; Genomics ; Hepatitis ; Hepatocellular carcinoma ; Humans ; immune infiltrates ; Immunofluorescence ; Immunohistochemistry ; Immunotherapy ; Liver cancer ; Liver Neoplasms - pathology ; Medical prognosis ; Metastases ; Microenvironments ; Original ; Patients ; Permeability ; Prognosis ; prognostic biomarker ; Proteins ; Solid tumors ; Tumor microenvironment ; Tumor Microenvironment - genetics ; Tumors ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - genetics ; Vascular Endothelial Growth Factor A - metabolism ; VEGFA ; Western blotting</subject><ispartof>Journal of cellular and molecular medicine, 2023-02, Vol.27 (4), p.538-552</ispartof><rights>2023 The Authors. published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.</rights><rights>2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.</rights><rights>2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4488-6ccdedb103524da4835a7d8cb755b79b54a8232fe72834998ac90e84a1a8df9e3</citedby><cites>FETCH-LOGICAL-c4488-6ccdedb103524da4835a7d8cb755b79b54a8232fe72834998ac90e84a1a8df9e3</cites><orcidid>0000-0002-5257-3922 ; 0000-0002-6310-5374 ; 0000-0002-6592-6678</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930434/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9930434/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36729917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qi, Yuchen</creatorcontrib><creatorcontrib>Song, Yinghui</creatorcontrib><creatorcontrib>Cai, Mengting</creatorcontrib><creatorcontrib>Li, Jianwen</creatorcontrib><creatorcontrib>Yu, Zhangtao</creatorcontrib><creatorcontrib>Li, Yuhang</creatorcontrib><creatorcontrib>Huang, Junkai</creatorcontrib><creatorcontrib>Jiang, Yu</creatorcontrib><creatorcontrib>Peng, Chuang</creatorcontrib><creatorcontrib>Jiang, Bo</creatorcontrib><creatorcontrib>Liu, Sulai</creatorcontrib><title>Vascular endothelial growth factor A is a potential prognostic biomarker and correlates with immune cell infiltration in hepatocellular carcinoma</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer‐related deaths among cancer patients. Vascular endothelial growth factor A (VEGFA) is involved in regulating biological processes, such as angiogenesis and vascular permeability, and is very closely related to the pathogenesis of various tumours, especially vascular‐rich, solid tumours. Clinical data of patients with HCC and other tumours were analysed through public databases, such as the TCGA database, Gene Expression Omnibus database, Human Protein Atlas database, STRING, Tumour Immune Estimation Resource and Kaplan–Meier Plotter. The tumour tissues and adjacent normal tissues of patients with HCC from Hunan Provincial People's Hospital were collected to verify the expression of VEGFA by immunohistochemistry, immunofluorescence, Western blotting and qPCR. VEGFA expression is elevated in multiple tumour types and correlates with the prognosis of tumour patients. VEGFA is involved in regulating the tumour microenvironment and immune cell function in tumour development. Inhibition of VEGFA reduces proliferation, invasion, and migration and promotes apoptosis in HCC cells. VEGFA is a potential predictive biomarker for the diagnosis and prognosis of HCC.</description><subject>Angiogenesis</subject><subject>Antibodies</subject><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - genetics</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - genetics</subject><subject>Cells</subject><subject>Gene expression</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Hepatitis</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>immune infiltrates</subject><subject>Immunofluorescence</subject><subject>Immunohistochemistry</subject><subject>Immunotherapy</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - pathology</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Microenvironments</subject><subject>Original</subject><subject>Patients</subject><subject>Permeability</subject><subject>Prognosis</subject><subject>prognostic biomarker</subject><subject>Proteins</subject><subject>Solid tumors</subject><subject>Tumor microenvironment</subject><subject>Tumor Microenvironment - genetics</subject><subject>Tumors</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>VEGFA</subject><subject>Western blotting</subject><issn>1582-1838</issn><issn>1582-4934</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kV2P1CAUhonRuB964w8wJN6YTWYthRa4MdlM_MxuvFFvySmlM4wUKlAn-zP8x9KdcaNeyE1pzpOH8-ZF6BmpLkk5r3Z6HC8Jb7l4gE5JI-oVk5Q9PN6JoOIEnaW0qyraEiofoxPa8lpKwk_Rz6-Q9OwgYuP7kLfGWXB4E8M-b_EAOoeIr7BNGPAUsvF5GU8xbHxI2Wrc2TBC_GYiBt9jHWI0DrJJeG-LwI7j7A3Wxjls_WBdjpBt8OUHb80EOSyju-c1RG19kT1BjwZwyTw9fs_Rl7dvPq_fr64_vfuwvrpeacaEWLVa96bvSEWbmvXABG2A90J3vGk6LruGgahpPRheC8qkFKBlZQQDAqIfpKHn6PXBO83daHpdskVwaoq2BLpVAaz6e-LtVm3CDyUlrRhlRfDyKIjh-2xSVqNNSx7wJsxJ1ZwTWXateEFf_IPuwhx9ibdQLZVCcFGoiwOlY0gpmuF-GVKppWm1NK3umi7w8z_Xv0d_V1sAcgD21pnb_6jUx_XNzUH6C8qKuIw</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Qi, Yuchen</creator><creator>Song, Yinghui</creator><creator>Cai, Mengting</creator><creator>Li, Jianwen</creator><creator>Yu, Zhangtao</creator><creator>Li, Yuhang</creator><creator>Huang, Junkai</creator><creator>Jiang, Yu</creator><creator>Peng, Chuang</creator><creator>Jiang, Bo</creator><creator>Liu, Sulai</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5257-3922</orcidid><orcidid>https://orcid.org/0000-0002-6310-5374</orcidid><orcidid>https://orcid.org/0000-0002-6592-6678</orcidid></search><sort><creationdate>202302</creationdate><title>Vascular endothelial growth factor A is a potential prognostic biomarker and correlates with immune cell infiltration in hepatocellular carcinoma</title><author>Qi, Yuchen ; Song, Yinghui ; Cai, Mengting ; Li, Jianwen ; Yu, Zhangtao ; Li, Yuhang ; Huang, Junkai ; Jiang, Yu ; Peng, Chuang ; Jiang, Bo ; Liu, Sulai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4488-6ccdedb103524da4835a7d8cb755b79b54a8232fe72834998ac90e84a1a8df9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Angiogenesis</topic><topic>Antibodies</topic><topic>Apoptosis</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qi, Yuchen</au><au>Song, Yinghui</au><au>Cai, Mengting</au><au>Li, Jianwen</au><au>Yu, Zhangtao</au><au>Li, Yuhang</au><au>Huang, Junkai</au><au>Jiang, Yu</au><au>Peng, Chuang</au><au>Jiang, Bo</au><au>Liu, Sulai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular endothelial growth factor A is a potential prognostic biomarker and correlates with immune cell infiltration in hepatocellular carcinoma</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2023-02</date><risdate>2023</risdate><volume>27</volume><issue>4</issue><spage>538</spage><epage>552</epage><pages>538-552</pages><issn>1582-1838</issn><issn>1582-4934</issn><eissn>1582-4934</eissn><abstract>Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer‐related deaths among cancer patients. Vascular endothelial growth factor A (VEGFA) is involved in regulating biological processes, such as angiogenesis and vascular permeability, and is very closely related to the pathogenesis of various tumours, especially vascular‐rich, solid tumours. Clinical data of patients with HCC and other tumours were analysed through public databases, such as the TCGA database, Gene Expression Omnibus database, Human Protein Atlas database, STRING, Tumour Immune Estimation Resource and Kaplan–Meier Plotter. The tumour tissues and adjacent normal tissues of patients with HCC from Hunan Provincial People's Hospital were collected to verify the expression of VEGFA by immunohistochemistry, immunofluorescence, Western blotting and qPCR. VEGFA expression is elevated in multiple tumour types and correlates with the prognosis of tumour patients. VEGFA is involved in regulating the tumour microenvironment and immune cell function in tumour development. Inhibition of VEGFA reduces proliferation, invasion, and migration and promotes apoptosis in HCC cells. VEGFA is a potential predictive biomarker for the diagnosis and prognosis of HCC.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>36729917</pmid><doi>10.1111/jcmm.17678</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-5257-3922</orcidid><orcidid>https://orcid.org/0000-0002-6310-5374</orcidid><orcidid>https://orcid.org/0000-0002-6592-6678</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Angiogenesis Antibodies Apoptosis Biomarkers Biomarkers, Tumor - genetics Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Cells Gene expression Genomes Genomics Hepatitis Hepatocellular carcinoma Humans immune infiltrates Immunofluorescence Immunohistochemistry Immunotherapy Liver cancer Liver Neoplasms - pathology Medical prognosis Metastases Microenvironments Original Patients Permeability Prognosis prognostic biomarker Proteins Solid tumors Tumor microenvironment Tumor Microenvironment - genetics Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism VEGFA Western blotting |
| title | Vascular endothelial growth factor A is a potential prognostic biomarker and correlates with immune cell infiltration in hepatocellular carcinoma |
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