Thermosensitive Biodegradable Hydrogels for Local and Controlled Cerebral Delivery of Proteins: MRI-Based Monitoring of In Vitro and In Vivo Protein Release

Hydrogels have been suggested as novel drug delivery systems for sustained release of therapeutic proteins in various neurological disorders. The main advantage these systems offer is the controlled, prolonged exposure to a therapeutically effective dose of the released drug after a single intracere...

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Veröffentlicht in:	ACS biomaterials science & engineering 2023-02, Vol.9 (2), p.760-772
Hauptverfasser:	Yanev, Pavel, van Tilborg, Geralda A.F., Boere, Kristel W. M., Stowe, Ann M., van der Toorn, Annette, Viergever, Max A., Hennink, Wim E., Vermonden, Tina, Dijkhuizen, Rick M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Controlled Release and Delivery Systems Drug Delivery Systems Hydrogels - chemistry Magnetic Resonance Imaging Male Polymers Proteins Rats Rats, Wistar
Online-Zugang:	Volltext
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