Ensembles of human myosin-19 bound to calmodulin and regulatory light chain RLC12B drive multimicron transport

Myosin-19 (Myo19) controls the size, morphology, and distribution of mitochondria, but the underlying role of Myo19 motor activity is unknown. Complicating mechanistic in vitro studies, the identity of the light chains (LCs) of Myo19 remains unsettled. Here, we show by coimmunoprecipitation, reconst...

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Veröffentlicht in:	The Journal of biological chemistry 2023-02, Vol.299 (2), p.102906-102906, Article 102906
Hauptverfasser:	Pollard, Luther W., Coscia, Stephen M., Rebowski, Grzegorz, Palmer, Nicholas J., Holzbaur, Erika L.F., Dominguez, Roberto, Ostap, E. Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	actin gliding Actins - metabolism calcium Calcium - metabolism calmodulin Calmodulin - metabolism HeLa Cells Humans mass spectrometry–based proteomics mitochondrial dynamics Myo19 myosin-19 myosin-XIX Myosins - metabolism processivity Qdot regulatory light chain
Online-Zugang:	Volltext
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