Aberrant alteration of peripheral B lymphocyte subsets in hepatocellular carcinoma patients
Although B lymphocytes are widely known to participate in the immune response, the conclusive roles of B lymphocyte subsets in the antitumor immune response have not yet been determined. Single-cell data from GEO datasets were first analyzed, and then a B cell flow cytometry panel was used to analyz...
Gespeichert in:
| Veröffentlicht in: | International journal of medical sciences 2023-01, Vol.20 (2), p.267-277 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 277 |
|---|---|
| container_issue | 2 |
| container_start_page | 267 |
| container_title | International journal of medical sciences |
| container_volume | 20 |
| creator | Wu, Jiaoxiang Wang, Yue Bai, Shihao Sun, Hanxiao Zhang, Jie Shu, Jie Wang, Yajie Tan, Meiyu Zhou, Lida Huang, Biao Pan, Qiuhui Sheng, Huiming |
| description | Although B lymphocytes are widely known to participate in the immune response, the conclusive roles of B lymphocyte subsets in the antitumor immune response have not yet been determined. Single-cell data from GEO datasets were first analyzed, and then a B cell flow cytometry panel was used to analyze the peripheral blood of 89 HCC patients and 33 healthy controls recruited to participate in our research. Patients with HCC had a higher frequency of B10 cells and a lower percentage of MZB cells than healthy controls. And the changes in B cell subsets might occur at an early stage. Moreover, the frequency of B10 cells decreased after surgery. Positively correlated with B10 cells, the elevated IL-10 level in HCC serum may be a new biomarker in HCC identification. For the first time, our results suggest that altered B cell subsets are associated with the development and prognosis of HCC. Increased B10 cell percentage and IL-10 in HCC patients suggest they might augment the development of liver tumors. Hence, B cell subsets and related cytokines may have predictive value in HCC patients and could be potential targets for immunotherapy in HCC. |
| doi_str_mv | 10.7150/ijms.79305 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9925981</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2772059142</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-e4239b7c578fe1539c617a3d589e8ec80b5898f6ee4aa3e551802bed50c50cc43</originalsourceid><addsrcrecordid>eNpdkUtLxDAUhYMozji68QdIwI0Io0nTNM1GUPEFghtduQhp5tbJ0DY1SYX592Z8DKMQyOXm4-QcDkKHlJwJysm5XbThTEhG-BYa0zyXUyqJ2N6YR2gvhAUhLGOC7qIRK4TMaZGP0etlBd7rLmLdRPA6WtdhV-MevO3nadHgK9ws237uzDICDkMVIAZsOzyHXkdnoGmGRntstDe2c63GaW2hi2Ef7dS6CXDwc0_Qy-3N8_X99PHp7uH68nFqWMHjFPKMyUoYLsoaKGfSFFRoNuOlhBJMSao0lXUBkGvNgHNakqyCGScmHZOzCbr41u2HqoWZSX8n36r3ttV-qZy26u9LZ-fqzX0oKTMuS5oETn4EvHsfIETV2rAKpjtwQ1CZECInTGQkocf_0IUbfJfiraiMcElTnAk6_aaMdyF4qNdmKFGrztSqM_XVWYKPNu2v0d-S2Cdr-pSs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2772059142</pqid></control><display><type>article</type><title>Aberrant alteration of peripheral B lymphocyte subsets in hepatocellular carcinoma patients</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Wu, Jiaoxiang ; Wang, Yue ; Bai, Shihao ; Sun, Hanxiao ; Zhang, Jie ; Shu, Jie ; Wang, Yajie ; Tan, Meiyu ; Zhou, Lida ; Huang, Biao ; Pan, Qiuhui ; Sheng, Huiming</creator><creatorcontrib>Wu, Jiaoxiang ; Wang, Yue ; Bai, Shihao ; Sun, Hanxiao ; Zhang, Jie ; Shu, Jie ; Wang, Yajie ; Tan, Meiyu ; Zhou, Lida ; Huang, Biao ; Pan, Qiuhui ; Sheng, Huiming</creatorcontrib><description>Although B lymphocytes are widely known to participate in the immune response, the conclusive roles of B lymphocyte subsets in the antitumor immune response have not yet been determined. Single-cell data from GEO datasets were first analyzed, and then a B cell flow cytometry panel was used to analyze the peripheral blood of 89 HCC patients and 33 healthy controls recruited to participate in our research. Patients with HCC had a higher frequency of B10 cells and a lower percentage of MZB cells than healthy controls. And the changes in B cell subsets might occur at an early stage. Moreover, the frequency of B10 cells decreased after surgery. Positively correlated with B10 cells, the elevated IL-10 level in HCC serum may be a new biomarker in HCC identification. For the first time, our results suggest that altered B cell subsets are associated with the development and prognosis of HCC. Increased B10 cell percentage and IL-10 in HCC patients suggest they might augment the development of liver tumors. Hence, B cell subsets and related cytokines may have predictive value in HCC patients and could be potential targets for immunotherapy in HCC.</description><identifier>ISSN: 1449-1907</identifier><identifier>EISSN: 1449-1907</identifier><identifier>DOI: 10.7150/ijms.79305</identifier><identifier>PMID: 36794164</identifier><language>eng</language><publisher>Australia: Ivyspring International Publisher Pty Ltd</publisher><subject>Antigens ; B-Lymphocyte Subsets ; Carcinoma, Hepatocellular ; Cytokines ; Datasets ; Flow cytometry ; Genes ; Genomics ; Hepatitis ; Humans ; Interleukin-10 ; Liver cancer ; Liver Neoplasms ; Lymphocytes ; Monoclonal antibodies ; Patients ; Research Paper ; Statistical analysis ; Tumors</subject><ispartof>International journal of medical sciences, 2023-01, Vol.20 (2), p.267-277</ispartof><rights>The author(s).</rights><rights>2023. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The author(s) 2023</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925981/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925981/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36794164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Jiaoxiang</creatorcontrib><creatorcontrib>Wang, Yue</creatorcontrib><creatorcontrib>Bai, Shihao</creatorcontrib><creatorcontrib>Sun, Hanxiao</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Shu, Jie</creatorcontrib><creatorcontrib>Wang, Yajie</creatorcontrib><creatorcontrib>Tan, Meiyu</creatorcontrib><creatorcontrib>Zhou, Lida</creatorcontrib><creatorcontrib>Huang, Biao</creatorcontrib><creatorcontrib>Pan, Qiuhui</creatorcontrib><creatorcontrib>Sheng, Huiming</creatorcontrib><title>Aberrant alteration of peripheral B lymphocyte subsets in hepatocellular carcinoma patients</title><title>International journal of medical sciences</title><addtitle>Int J Med Sci</addtitle><description>Although B lymphocytes are widely known to participate in the immune response, the conclusive roles of B lymphocyte subsets in the antitumor immune response have not yet been determined. Single-cell data from GEO datasets were first analyzed, and then a B cell flow cytometry panel was used to analyze the peripheral blood of 89 HCC patients and 33 healthy controls recruited to participate in our research. Patients with HCC had a higher frequency of B10 cells and a lower percentage of MZB cells than healthy controls. And the changes in B cell subsets might occur at an early stage. Moreover, the frequency of B10 cells decreased after surgery. Positively correlated with B10 cells, the elevated IL-10 level in HCC serum may be a new biomarker in HCC identification. For the first time, our results suggest that altered B cell subsets are associated with the development and prognosis of HCC. Increased B10 cell percentage and IL-10 in HCC patients suggest they might augment the development of liver tumors. Hence, B cell subsets and related cytokines may have predictive value in HCC patients and could be potential targets for immunotherapy in HCC.</description><subject>Antigens</subject><subject>B-Lymphocyte Subsets</subject><subject>Carcinoma, Hepatocellular</subject><subject>Cytokines</subject><subject>Datasets</subject><subject>Flow cytometry</subject><subject>Genes</subject><subject>Genomics</subject><subject>Hepatitis</subject><subject>Humans</subject><subject>Interleukin-10</subject><subject>Liver cancer</subject><subject>Liver Neoplasms</subject><subject>Lymphocytes</subject><subject>Monoclonal antibodies</subject><subject>Patients</subject><subject>Research Paper</subject><subject>Statistical analysis</subject><subject>Tumors</subject><issn>1449-1907</issn><issn>1449-1907</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkUtLxDAUhYMozji68QdIwI0Io0nTNM1GUPEFghtduQhp5tbJ0DY1SYX592Z8DKMQyOXm4-QcDkKHlJwJysm5XbThTEhG-BYa0zyXUyqJ2N6YR2gvhAUhLGOC7qIRK4TMaZGP0etlBd7rLmLdRPA6WtdhV-MevO3nadHgK9ws237uzDICDkMVIAZsOzyHXkdnoGmGRntstDe2c63GaW2hi2Ef7dS6CXDwc0_Qy-3N8_X99PHp7uH68nFqWMHjFPKMyUoYLsoaKGfSFFRoNuOlhBJMSao0lXUBkGvNgHNakqyCGScmHZOzCbr41u2HqoWZSX8n36r3ttV-qZy26u9LZ-fqzX0oKTMuS5oETn4EvHsfIETV2rAKpjtwQ1CZECInTGQkocf_0IUbfJfiraiMcElTnAk6_aaMdyF4qNdmKFGrztSqM_XVWYKPNu2v0d-S2Cdr-pSs</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Wu, Jiaoxiang</creator><creator>Wang, Yue</creator><creator>Bai, Shihao</creator><creator>Sun, Hanxiao</creator><creator>Zhang, Jie</creator><creator>Shu, Jie</creator><creator>Wang, Yajie</creator><creator>Tan, Meiyu</creator><creator>Zhou, Lida</creator><creator>Huang, Biao</creator><creator>Pan, Qiuhui</creator><creator>Sheng, Huiming</creator><general>Ivyspring International Publisher Pty Ltd</general><general>Ivyspring International Publisher</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230101</creationdate><title>Aberrant alteration of peripheral B lymphocyte subsets in hepatocellular carcinoma patients</title><author>Wu, Jiaoxiang ; Wang, Yue ; Bai, Shihao ; Sun, Hanxiao ; Zhang, Jie ; Shu, Jie ; Wang, Yajie ; Tan, Meiyu ; Zhou, Lida ; Huang, Biao ; Pan, Qiuhui ; Sheng, Huiming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-e4239b7c578fe1539c617a3d589e8ec80b5898f6ee4aa3e551802bed50c50cc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antigens</topic><topic>B-Lymphocyte Subsets</topic><topic>Carcinoma, Hepatocellular</topic><topic>Cytokines</topic><topic>Datasets</topic><topic>Flow cytometry</topic><topic>Genes</topic><topic>Genomics</topic><topic>Hepatitis</topic><topic>Humans</topic><topic>Interleukin-10</topic><topic>Liver cancer</topic><topic>Liver Neoplasms</topic><topic>Lymphocytes</topic><topic>Monoclonal antibodies</topic><topic>Patients</topic><topic>Research Paper</topic><topic>Statistical analysis</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Wu, Jiaoxiang</creatorcontrib><creatorcontrib>Wang, Yue</creatorcontrib><creatorcontrib>Bai, Shihao</creatorcontrib><creatorcontrib>Sun, Hanxiao</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Shu, Jie</creatorcontrib><creatorcontrib>Wang, Yajie</creatorcontrib><creatorcontrib>Tan, Meiyu</creatorcontrib><creatorcontrib>Zhou, Lida</creatorcontrib><creatorcontrib>Huang, Biao</creatorcontrib><creatorcontrib>Pan, Qiuhui</creatorcontrib><creatorcontrib>Sheng, Huiming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Jiaoxiang</au><au>Wang, Yue</au><au>Bai, Shihao</au><au>Sun, Hanxiao</au><au>Zhang, Jie</au><au>Shu, Jie</au><au>Wang, Yajie</au><au>Tan, Meiyu</au><au>Zhou, Lida</au><au>Huang, Biao</au><au>Pan, Qiuhui</au><au>Sheng, Huiming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aberrant alteration of peripheral B lymphocyte subsets in hepatocellular carcinoma patients</atitle><jtitle>International journal of medical sciences</jtitle><addtitle>Int J Med Sci</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>20</volume><issue>2</issue><spage>267</spage><epage>277</epage><pages>267-277</pages><issn>1449-1907</issn><eissn>1449-1907</eissn><abstract>Although B lymphocytes are widely known to participate in the immune response, the conclusive roles of B lymphocyte subsets in the antitumor immune response have not yet been determined. Single-cell data from GEO datasets were first analyzed, and then a B cell flow cytometry panel was used to analyze the peripheral blood of 89 HCC patients and 33 healthy controls recruited to participate in our research. Patients with HCC had a higher frequency of B10 cells and a lower percentage of MZB cells than healthy controls. And the changes in B cell subsets might occur at an early stage. Moreover, the frequency of B10 cells decreased after surgery. Positively correlated with B10 cells, the elevated IL-10 level in HCC serum may be a new biomarker in HCC identification. For the first time, our results suggest that altered B cell subsets are associated with the development and prognosis of HCC. Increased B10 cell percentage and IL-10 in HCC patients suggest they might augment the development of liver tumors. Hence, B cell subsets and related cytokines may have predictive value in HCC patients and could be potential targets for immunotherapy in HCC.</abstract><cop>Australia</cop><pub>Ivyspring International Publisher Pty Ltd</pub><pmid>36794164</pmid><doi>10.7150/ijms.79305</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1449-1907 |
| ispartof | International journal of medical sciences, 2023-01, Vol.20 (2), p.267-277 |
| issn | 1449-1907 1449-1907 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9925981 |
| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Antigens B-Lymphocyte Subsets Carcinoma, Hepatocellular Cytokines Datasets Flow cytometry Genes Genomics Hepatitis Humans Interleukin-10 Liver cancer Liver Neoplasms Lymphocytes Monoclonal antibodies Patients Research Paper Statistical analysis Tumors |
| title | Aberrant alteration of peripheral B lymphocyte subsets in hepatocellular carcinoma patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T22%3A06%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aberrant%20alteration%20of%20peripheral%20B%20lymphocyte%20subsets%20in%20hepatocellular%20carcinoma%20patients&rft.jtitle=International%20journal%20of%20medical%20sciences&rft.au=Wu,%20Jiaoxiang&rft.date=2023-01-01&rft.volume=20&rft.issue=2&rft.spage=267&rft.epage=277&rft.pages=267-277&rft.issn=1449-1907&rft.eissn=1449-1907&rft_id=info:doi/10.7150/ijms.79305&rft_dat=%3Cproquest_pubme%3E2772059142%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2772059142&rft_id=info:pmid/36794164&rfr_iscdi=true |