Ferroptosis-related NFE2L2 and NOX4 Genes are Potential Risk Prognostic Biomarkers and Correlated with Immunogenic Features in Glioma
Ferroptosis is a newfound mode of regulated cell death that may have potential to associate with prognostic or diagnostic factors in glioma. In this research, 5 genes related to glioma were screened through the FerrDb database, and we analyzed the combination between genes and glioma of survival and...
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| Veröffentlicht in: | Cell biochemistry and biophysics 2023-03, Vol.81 (1), p.7-17 |
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| creator | Lin, Li Li, Xiaona Zhu, Shunda Long, Qingshan Hu, Yongzhen Zhang, Liyang Liu, Zexin Li, Bo Li, Xuesong |
| description | Ferroptosis is a newfound mode of regulated cell death that may have potential to associate with prognostic or diagnostic factors in glioma. In this research, 5 genes related to glioma were screened through the FerrDb database, and we analyzed the combination between genes and glioma of survival and prognosis via TCGA, GEPIA, TIMER, and other databases. Survival curve and prognostic analysis showed that the overexpression of
NFE2L2
and
NOX4
, respectively, has a remarkable link with a worse prognosis in glioma. Then, the association between the expression of the two genes and tumor-infiltrating immune cells level was explored based on the GSCA, and the immunity of
NFE2L2
and
NOX4
based on the TISIDB database was also investigated. In glioma, especially GBM, there is a strong association between gene expression and immune infiltration, even in macrophages, nTreg, and Th2 cells, which play immunosuppressive functions in TME. In conclusion, these results indicate that
NFE2L2
and
NOX4
could be risk prognosis biomarkers in glioma, and they bound up with immune infiltration and tumor immunity in tumorigenesis. |
| doi_str_mv | 10.1007/s12013-022-01124-x |
| format | Article |
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NFE2L2
and
NOX4
, respectively, has a remarkable link with a worse prognosis in glioma. Then, the association between the expression of the two genes and tumor-infiltrating immune cells level was explored based on the GSCA, and the immunity of
NFE2L2
and
NOX4
based on the TISIDB database was also investigated. In glioma, especially GBM, there is a strong association between gene expression and immune infiltration, even in macrophages, nTreg, and Th2 cells, which play immunosuppressive functions in TME. In conclusion, these results indicate that
NFE2L2
and
NOX4
could be risk prognosis biomarkers in glioma, and they bound up with immune infiltration and tumor immunity in tumorigenesis.</description><identifier>ISSN: 1085-9195</identifier><identifier>EISSN: 1559-0283</identifier><identifier>DOI: 10.1007/s12013-022-01124-x</identifier><identifier>PMID: 36627482</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Biological and Medical Physics ; Biomarkers ; Biomarkers, Tumor - genetics ; Biomedical and Life Sciences ; Biophysics ; Biotechnology ; Brain tumors ; Carcinogenesis ; Cell Biology ; Cell death ; Ferroptosis ; Ferroptosis - genetics ; Gene expression ; Genes ; Glioma ; Glioma - genetics ; Helper cells ; Humans ; Immune system ; Immunity ; Immunogenicity ; Infiltration ; Life Sciences ; Lymphocytes T ; Macrophages ; Medical prognosis ; Metastases ; NADPH Oxidase 4 - genetics ; NF-E2-Related Factor 2 - genetics ; NOX4 protein ; Pharmacology/Toxicology ; Prognosis ; Review Paper ; Survival ; Tumor-infiltrating lymphocytes ; Tumorigenesis ; Tumors</subject><ispartof>Cell biochemistry and biophysics, 2023-03, Vol.81 (1), p.7-17</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-9c01ebf90bc249fc055e1be59ea53dc839fe7c6f6d4cabdffff97e64ba45d4703</citedby><cites>FETCH-LOGICAL-c474t-9c01ebf90bc249fc055e1be59ea53dc839fe7c6f6d4cabdffff97e64ba45d4703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12013-022-01124-x$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12013-022-01124-x$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36627482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Li</creatorcontrib><creatorcontrib>Li, Xiaona</creatorcontrib><creatorcontrib>Zhu, Shunda</creatorcontrib><creatorcontrib>Long, Qingshan</creatorcontrib><creatorcontrib>Hu, Yongzhen</creatorcontrib><creatorcontrib>Zhang, Liyang</creatorcontrib><creatorcontrib>Liu, Zexin</creatorcontrib><creatorcontrib>Li, Bo</creatorcontrib><creatorcontrib>Li, Xuesong</creatorcontrib><title>Ferroptosis-related NFE2L2 and NOX4 Genes are Potential Risk Prognostic Biomarkers and Correlated with Immunogenic Features in Glioma</title><title>Cell biochemistry and biophysics</title><addtitle>Cell Biochem Biophys</addtitle><addtitle>Cell Biochem Biophys</addtitle><description>Ferroptosis is a newfound mode of regulated cell death that may have potential to associate with prognostic or diagnostic factors in glioma. In this research, 5 genes related to glioma were screened through the FerrDb database, and we analyzed the combination between genes and glioma of survival and prognosis via TCGA, GEPIA, TIMER, and other databases. Survival curve and prognostic analysis showed that the overexpression of
NFE2L2
and
NOX4
, respectively, has a remarkable link with a worse prognosis in glioma. Then, the association between the expression of the two genes and tumor-infiltrating immune cells level was explored based on the GSCA, and the immunity of
NFE2L2
and
NOX4
based on the TISIDB database was also investigated. In glioma, especially GBM, there is a strong association between gene expression and immune infiltration, even in macrophages, nTreg, and Th2 cells, which play immunosuppressive functions in TME. In conclusion, these results indicate that
NFE2L2
and
NOX4
could be risk prognosis biomarkers in glioma, and they bound up with immune infiltration and tumor immunity in tumorigenesis.</description><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biophysics</subject><subject>Biotechnology</subject><subject>Brain tumors</subject><subject>Carcinogenesis</subject><subject>Cell Biology</subject><subject>Cell death</subject><subject>Ferroptosis</subject><subject>Ferroptosis - genetics</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Glioma</subject><subject>Glioma - genetics</subject><subject>Helper cells</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Immunogenicity</subject><subject>Infiltration</subject><subject>Life Sciences</subject><subject>Lymphocytes T</subject><subject>Macrophages</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>NADPH Oxidase 4 - genetics</subject><subject>NF-E2-Related Factor 2 - genetics</subject><subject>NOX4 protein</subject><subject>Pharmacology/Toxicology</subject><subject>Prognosis</subject><subject>Review Paper</subject><subject>Survival</subject><subject>Tumor-infiltrating lymphocytes</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>1085-9195</issn><issn>1559-0283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1u1DAUhSMEoj_wAiyQJTZsArZjJ_EGCUadodKIVggkdpbj3EzdJvbUdqB9AN6b205bfhZ44yvf7xzfq1MULxh9wyht3ibGKatKynlJGeOivHpU7DMpFT611WOsaStLxZTcKw5SOqdIUiGeFntVXfNGtHy_-LmEGMM2h-RSGWE0GXryaXnE15wYj-XJN0FW4CERE4Gchgw-OzOSzy5dkNMYNj6k7Cz54MJk4gXEdKtbhHjv9sPlM3I8TbMPG_CILsHkOaKj82Q13uieFU8GMyZ4fncfFl-XR18WH8v1yep48X5dWtGIXCpLGXSDop3lQg2WSgmsA6nAyKq3baUGaGw91L2wpusHPKqBWnRGyF40tDos3u18t3M3QW9xl2hGvY0OZ7_WwTj9d8e7M70J37VSXErG0eD1nUEMlzOkrCeXLIyj8RDmpHlTCyGo5ALRV_-g52GOHtdDqpFtXUlRI8V3lI0hpQjDwzCM6puU9S5ljdnp25T1FYpe_rnGg-Q-VgSqHZCw5TcQf__9H9tfZqe2Ag</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Lin, Li</creator><creator>Li, Xiaona</creator><creator>Zhu, Shunda</creator><creator>Long, Qingshan</creator><creator>Hu, Yongzhen</creator><creator>Zhang, Liyang</creator><creator>Liu, Zexin</creator><creator>Li, Bo</creator><creator>Li, Xuesong</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230301</creationdate><title>Ferroptosis-related NFE2L2 and NOX4 Genes are Potential Risk Prognostic Biomarkers and Correlated with Immunogenic Features in Glioma</title><author>Lin, Li ; Li, Xiaona ; Zhu, Shunda ; Long, Qingshan ; Hu, Yongzhen ; Zhang, Liyang ; Liu, Zexin ; Li, Bo ; Li, Xuesong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-9c01ebf90bc249fc055e1be59ea53dc839fe7c6f6d4cabdffff97e64ba45d4703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biochemistry</topic><topic>Biological and Medical Physics</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Li</au><au>Li, Xiaona</au><au>Zhu, Shunda</au><au>Long, Qingshan</au><au>Hu, Yongzhen</au><au>Zhang, Liyang</au><au>Liu, Zexin</au><au>Li, Bo</au><au>Li, Xuesong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ferroptosis-related NFE2L2 and NOX4 Genes are Potential Risk Prognostic Biomarkers and Correlated with Immunogenic Features in Glioma</atitle><jtitle>Cell biochemistry and biophysics</jtitle><stitle>Cell Biochem Biophys</stitle><addtitle>Cell Biochem Biophys</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>81</volume><issue>1</issue><spage>7</spage><epage>17</epage><pages>7-17</pages><issn>1085-9195</issn><eissn>1559-0283</eissn><abstract>Ferroptosis is a newfound mode of regulated cell death that may have potential to associate with prognostic or diagnostic factors in glioma. In this research, 5 genes related to glioma were screened through the FerrDb database, and we analyzed the combination between genes and glioma of survival and prognosis via TCGA, GEPIA, TIMER, and other databases. Survival curve and prognostic analysis showed that the overexpression of
NFE2L2
and
NOX4
, respectively, has a remarkable link with a worse prognosis in glioma. Then, the association between the expression of the two genes and tumor-infiltrating immune cells level was explored based on the GSCA, and the immunity of
NFE2L2
and
NOX4
based on the TISIDB database was also investigated. In glioma, especially GBM, there is a strong association between gene expression and immune infiltration, even in macrophages, nTreg, and Th2 cells, which play immunosuppressive functions in TME. In conclusion, these results indicate that
NFE2L2
and
NOX4
could be risk prognosis biomarkers in glioma, and they bound up with immune infiltration and tumor immunity in tumorigenesis.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36627482</pmid><doi>10.1007/s12013-022-01124-x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cell biochemistry and biophysics, 2023-03, Vol.81 (1), p.7-17 |
| issn | 1085-9195 1559-0283 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9925512 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Biochemistry Biological and Medical Physics Biomarkers Biomarkers, Tumor - genetics Biomedical and Life Sciences Biophysics Biotechnology Brain tumors Carcinogenesis Cell Biology Cell death Ferroptosis Ferroptosis - genetics Gene expression Genes Glioma Glioma - genetics Helper cells Humans Immune system Immunity Immunogenicity Infiltration Life Sciences Lymphocytes T Macrophages Medical prognosis Metastases NADPH Oxidase 4 - genetics NF-E2-Related Factor 2 - genetics NOX4 protein Pharmacology/Toxicology Prognosis Review Paper Survival Tumor-infiltrating lymphocytes Tumorigenesis Tumors |
| title | Ferroptosis-related NFE2L2 and NOX4 Genes are Potential Risk Prognostic Biomarkers and Correlated with Immunogenic Features in Glioma |
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