Dynamic SUMOylation of MORC2 orchestrates chromatin remodelling and DNA repair in response to DNA damage and drives chemoresistance in breast cancer

SUMOylation regulates a plethora of biological processes, and its inhibitors are currently under investigation in clinical trials as anticancer agents. Thus, identifying new targets with site-specific SUMOylation and defining their biological functions will not only provide new mechanistic insights...

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Veröffentlicht in:	Theranostics 2023-01, Vol.13 (3), p.973-990
Hauptverfasser:	Zhang, Fang-Lin, Yang, Shao-Ying, Liao, Li, Zhang, Tai-Mei, Zhang, Yin-Ling, Hu, Shu-Yuan, Deng, Ling, Huang, Min-Ying, Andriani, Lisa, Ma, Xiao-Yan, Shao, Zhi-Min, Li, Da-Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Chromatin Chromatin Assembly and Disassembly DNA Damage DNA Repair Drug Resistance, Neoplasm - genetics Female Humans Research Paper Sumoylation Transcription Factors - metabolism
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