Lipid Droplet Protein PLIN1 Regulates Inflammatory Polarity in Human Macrophages and is Involved in Atherosclerotic Plaque Development by Promoting Stable Lipid Storage

Aim: Perilipins (PLINs), peripheral lipid droplet (LD) proteins, play important roles in lipid accumulation and maturation in adipocytes. The relationship between PLIN family proteins and macrophage polarization in atherosclerosis has not been elucidated.Methods: The experiments used tissues from hu...

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Veröffentlicht in:	Journal of Atherosclerosis and Thrombosis 2023/02/01, Vol.30(2), pp.170-181
Hauptverfasser:	Cho, Kyu Yong, Miyoshi, Hideaki, Nakamura, Akinobu, Greenberg, Andrew S, Atsumi, Tatsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis Humans Inflammation Leukocytes, Mononuclear - metabolism Lipid droplet protein Lipid Droplets - metabolism Lipids Macrophages Macrophages - metabolism Original Perilipin Perilipin-1 - genetics Perilipin-1 - metabolism Perilipin-2 - genetics Perilipin-2 - metabolism Plaque, Atherosclerotic - metabolism RNA - metabolism
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