DNA Repair Genes Polymorphisms: Impact on Acute Myeloid Leukemia Patients Outcome

DNA Repair Genes Polymorphisms: Impact on Acute Myeloid Leukemia Patients Outcome

ATM; XRCC6 and LIG4 genes play an important role in repairing the double-strand DNA breaks and maintaining the genome stability. Single nucleotide polymorphisms (SNPs) in these genes could affect these genes expression and function. The aim of this study was to address the effect of SNP of the DNA r...

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Veröffentlicht in:Asian Pacific Journal of Cancer Prevention 2022-10, Vol.23 (10), p.3577-3585
Hauptverfasser: Aref, Salah, El Menshawy, Nadia, Abou Zeid, Tarek, Gouda, Enas, Abdel Aziz, Nora
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Sprache:eng
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Cross-Sectional Studies
DNA Ligase ATP - genetics
DNA Repair - genetics
Genetic Predisposition to Disease
Genotype
Humans
Leukemia, Myeloid, Acute - genetics
Polymorphism, Single Nucleotide
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container_end_page 3585
container_issue 10
container_start_page 3577
container_title Asian Pacific Journal of Cancer Prevention
container_volume 23
creator Aref, Salah
El Menshawy, Nadia
Abou Zeid, Tarek
Gouda, Enas
Abdel Aziz, Nora
description ATM; XRCC6 and LIG4 genes play an important role in repairing the double-strand DNA breaks and maintaining the genome stability. Single nucleotide polymorphisms (SNPs) in these genes could affect these genes expression and function. The aim of this study was to address the effect of SNP of the DNA repairing genes on corresponding  gene expression as well as AML patient's outcome. This is cross sectional study included 95 newly diagnosed AML patients. For all subjects included in our study SNPs  and expression of ATM (rs189037G>A), XRCC6 (rs2267437C>G) and LIG4 (rs1805388C>T) genes were evaluated by RFLP and real time PCR. The following SNPs in ATM (AA); XRCC6 (GG); and LIG4 (TT) are associated with down regulation of the corresponding genes (P
doi_str_mv 10.31557/APJCP.2022.23.10.3577
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Single nucleotide polymorphisms (SNPs) in these genes could affect these genes expression and function. The aim of this study was to address the effect of SNP of the DNA repairing genes on corresponding  gene expression as well as AML patient's outcome. This is cross sectional study included 95 newly diagnosed AML patients. For all subjects included in our study SNPs  and expression of ATM (rs189037G&gt;A), XRCC6 (rs2267437C&gt;G) and LIG4 (rs1805388C&gt;T) genes were evaluated by RFLP and real time PCR. The following SNPs in ATM (AA); XRCC6 (GG); and LIG4 (TT) are associated with down regulation of the corresponding genes (P&lt;0.001). The lower expression of ATM and LIG4 genes are associated with shorter OS and DFS. Cox regression multivariate analysis revealed that lower expression of ATM HR : 2.02 (CI: 1.12-3.64; p=0.020. The following SNPs of ATM (AA); XRCC6 (GG); and LIG4 (TT) are associated with down regulation of corresponding genes expression. 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Single nucleotide polymorphisms (SNPs) in these genes could affect these genes expression and function. The aim of this study was to address the effect of SNP of the DNA repairing genes on corresponding  gene expression as well as AML patient's outcome. This is cross sectional study included 95 newly diagnosed AML patients. For all subjects included in our study SNPs  and expression of ATM (rs189037G&gt;A), XRCC6 (rs2267437C&gt;G) and LIG4 (rs1805388C&gt;T) genes were evaluated by RFLP and real time PCR. The following SNPs in ATM (AA); XRCC6 (GG); and LIG4 (TT) are associated with down regulation of the corresponding genes (P&lt;0.001). The lower expression of ATM and LIG4 genes are associated with shorter OS and DFS. Cox regression multivariate analysis revealed that lower expression of ATM HR : 2.02 (CI: 1.12-3.64; p=0.020. The following SNPs of ATM (AA); XRCC6 (GG); and LIG4 (TT) are associated with down regulation of corresponding genes expression. 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subjects Cross-Sectional Studies
DNA Ligase ATP - genetics
DNA Repair - genetics
Genetic Predisposition to Disease
Genotype
Humans
Leukemia, Myeloid, Acute - genetics
Polymorphism, Single Nucleotide
title DNA Repair Genes Polymorphisms: Impact on Acute Myeloid Leukemia Patients Outcome
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