Influence of Maternal Metabolic Status and Diet during the Perinatal Period on the Metabolic Programming by Leptin Ingested during the Suckling Period in Rats
We aimed to analyze the long-term metabolic effects of leptin supplementation at physiological doses during suckling in the offspring of diet-induced obese rats, together with the potential benefits of improving maternal diet during lactation. Thus, the offspring of: dams fed standard-diet (SD) (CON...
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| Veröffentlicht in: | Nutrients 2023-01, Vol.15 (3), p.570 |
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| description | We aimed to analyze the long-term metabolic effects of leptin supplementation at physiological doses during suckling in the offspring of diet-induced obese rats, together with the potential benefits of improving maternal diet during lactation. Thus, the offspring of: dams fed standard-diet (SD) (CON-dams), dams fed western-diet (WD) before and during gestation and lactation (WD-dams), and dams fed as WD-dams but moved to SD during lactation (REV-dams) were supplemented throughout suckling with leptin or vehicle, and fed SD or WD from weaning to four months. Under SD, leptin treatment significantly improved metabolic profile and body fat accumulation, with stronger effects in the male offspring of CON-dams and REV-dams. Under WD, the offspring of WD-dams presented metabolic alterations that were not evident in the offspring of REV-dams. Moreover, leptin supplementation improved glucose homeostasis in the male offspring of REV-dams. Conversely, leptin supplementation in females born to WD-dams and fed WD from weaning resulted in impaired insulin sensitivity and increased hepatic lipid content. These results highlight the importance of a balanced maternal diet during the perinatal period, especially lactation, for the subsequent metabolic health of the offspring and for the beneficial effects of leptin supplementation during suckling, more evident in the male offspring. |
| doi_str_mv | 10.3390/nu15030570 |
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Thus, the offspring of: dams fed standard-diet (SD) (CON-dams), dams fed western-diet (WD) before and during gestation and lactation (WD-dams), and dams fed as WD-dams but moved to SD during lactation (REV-dams) were supplemented throughout suckling with leptin or vehicle, and fed SD or WD from weaning to four months. Under SD, leptin treatment significantly improved metabolic profile and body fat accumulation, with stronger effects in the male offspring of CON-dams and REV-dams. Under WD, the offspring of WD-dams presented metabolic alterations that were not evident in the offspring of REV-dams. Moreover, leptin supplementation improved glucose homeostasis in the male offspring of REV-dams. Conversely, leptin supplementation in females born to WD-dams and fed WD from weaning resulted in impaired insulin sensitivity and increased hepatic lipid content. These results highlight the importance of a balanced maternal diet during the perinatal period, especially lactation, for the subsequent metabolic health of the offspring and for the beneficial effects of leptin supplementation during suckling, more evident in the male offspring.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu15030570</identifier><identifier>PMID: 36771278</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adiposity ; Age ; Animals ; Baby foods ; Body fat ; Carbohydrates ; Diet ; Fatty liver ; Female ; Females ; Food and nutrition ; glucose ; Health aspects ; Homeostasis ; Insulin ; Insulin resistance ; Laboratory animals ; Lactation ; Leptin ; Leptin - metabolism ; lipid content ; Lipids ; Liver ; Male ; Males ; maternal nutrition ; Maternal Nutritional Physiological Phenomena ; Metabolism ; Mothers ; Obesity ; Obesity - metabolism ; Offspring ; Overweight ; Parturition ; perinatal period ; Physiological aspects ; Physiological effects ; Pregnancy ; Pregnant women ; Prenatal Exposure Delayed Effects ; Prenatal influences ; progeny ; Rats ; Risk factors ; Sterols ; Suckling behavior ; Transcription factors ; Variance analysis ; Weaning ; Western diets ; Womens health</subject><ispartof>Nutrients, 2023-01, Vol.15 (3), p.570</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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These results highlight the importance of a balanced maternal diet during the perinatal period, especially lactation, for the subsequent metabolic health of the offspring and for the beneficial effects of leptin supplementation during suckling, more evident in the male offspring.</description><subject>Adiposity</subject><subject>Age</subject><subject>Animals</subject><subject>Baby foods</subject><subject>Body fat</subject><subject>Carbohydrates</subject><subject>Diet</subject><subject>Fatty liver</subject><subject>Female</subject><subject>Females</subject><subject>Food and nutrition</subject><subject>glucose</subject><subject>Health aspects</subject><subject>Homeostasis</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Laboratory animals</subject><subject>Lactation</subject><subject>Leptin</subject><subject>Leptin - metabolism</subject><subject>lipid content</subject><subject>Lipids</subject><subject>Liver</subject><subject>Male</subject><subject>Males</subject><subject>maternal nutrition</subject><subject>Maternal Nutritional Physiological Phenomena</subject><subject>Metabolism</subject><subject>Mothers</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Offspring</subject><subject>Overweight</subject><subject>Parturition</subject><subject>perinatal period</subject><subject>Physiological aspects</subject><subject>Physiological effects</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Prenatal influences</subject><subject>progeny</subject><subject>Rats</subject><subject>Risk factors</subject><subject>Sterols</subject><subject>Suckling behavior</subject><subject>Transcription factors</subject><subject>Variance analysis</subject><subject>Weaning</subject><subject>Western diets</subject><subject>Womens health</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkl1rFDEUhgdRbKm98QdIwBsRtuY7MzdCqV8LWyxWr0Mmc7JNnUnWSUbon_G3mmnX7lYEk4ucJM_7kpxzquo5wSeMNfhNmIjADAuFH1WHFCu6kJKzx3vxQXWc0jWeh8JKsqfVAZNKEarqw-rXMrh-gmABRYfOTYYxmB6dQzZt7L1Fl9nkKSETOvTOQ0bdNPqwRvkK0AWU0OSCz1HsUAy35zvxxRjXoxmGWdHeoBVssg9oGdaQMnT7XpeT_d7Pm61Vwb6YnJ5VT5zpExxv16Pq24f3X88-LVafPy7PTlcLK7DMCwEKO4lb4ixXTNaCqA5zTltcA6uFYtQ2IB3H0rlGCGmEpIJ3tWmpkAJqdlS9vfPdTO0AnYWQR9PrzegHM97oaLx-eBP8lV7Hn7ppKBFMFINXW4Mx_pjK9_Tgk4W-NwHilDTDHLMaS8L_i1KlhCSlcrPry7_Q6zjNBbqleCMIJnJHrU0P2gcXyxPtbKpPFWdUMFXTQp38gyqzg8HbGMD5cv5A8PpOYMeY0gjuPh0E67n39K73CvxiP4H36J9OY78BmCbS6Q</recordid><startdate>20230121</startdate><enddate>20230121</enddate><creator>Castillo, Pedro</creator><creator>Pomar, Catalina Amadora</creator><creator>Palou, Andreu</creator><creator>Palou, Mariona</creator><creator>Picó, Catalina</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8113-761X</orcidid><orcidid>https://orcid.org/0000-0001-9918-3764</orcidid><orcidid>https://orcid.org/0000-0001-6759-5844</orcidid><orcidid>https://orcid.org/0000-0002-0295-4452</orcidid></search><sort><creationdate>20230121</creationdate><title>Influence of Maternal Metabolic Status and Diet during the Perinatal Period on the Metabolic Programming by Leptin Ingested during the Suckling Period in Rats</title><author>Castillo, Pedro ; Pomar, Catalina Amadora ; Palou, Andreu ; Palou, Mariona ; Picó, Catalina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-5e70f60b1fc47368517d0442b08e385732c9e6f406ff9556a56254d8ab2565e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adiposity</topic><topic>Age</topic><topic>Animals</topic><topic>Baby foods</topic><topic>Body fat</topic><topic>Carbohydrates</topic><topic>Diet</topic><topic>Fatty liver</topic><topic>Female</topic><topic>Females</topic><topic>Food and nutrition</topic><topic>glucose</topic><topic>Health aspects</topic><topic>Homeostasis</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Laboratory animals</topic><topic>Lactation</topic><topic>Leptin</topic><topic>Leptin - metabolism</topic><topic>lipid content</topic><topic>Lipids</topic><topic>Liver</topic><topic>Male</topic><topic>Males</topic><topic>maternal nutrition</topic><topic>Maternal Nutritional Physiological Phenomena</topic><topic>Metabolism</topic><topic>Mothers</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Offspring</topic><topic>Overweight</topic><topic>Parturition</topic><topic>perinatal period</topic><topic>Physiological aspects</topic><topic>Physiological effects</topic><topic>Pregnancy</topic><topic>Pregnant women</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Prenatal influences</topic><topic>progeny</topic><topic>Rats</topic><topic>Risk factors</topic><topic>Sterols</topic><topic>Suckling behavior</topic><topic>Transcription factors</topic><topic>Variance analysis</topic><topic>Weaning</topic><topic>Western diets</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castillo, Pedro</creatorcontrib><creatorcontrib>Pomar, Catalina Amadora</creatorcontrib><creatorcontrib>Palou, Andreu</creatorcontrib><creatorcontrib>Palou, Mariona</creatorcontrib><creatorcontrib>Picó, Catalina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castillo, Pedro</au><au>Pomar, Catalina Amadora</au><au>Palou, Andreu</au><au>Palou, Mariona</au><au>Picó, Catalina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Maternal Metabolic Status and Diet during the Perinatal Period on the Metabolic Programming by Leptin Ingested during the Suckling Period in Rats</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2023-01-21</date><risdate>2023</risdate><volume>15</volume><issue>3</issue><spage>570</spage><pages>570-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>We aimed to analyze the long-term metabolic effects of leptin supplementation at physiological doses during suckling in the offspring of diet-induced obese rats, together with the potential benefits of improving maternal diet during lactation. 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| subjects | Adiposity Age Animals Baby foods Body fat Carbohydrates Diet Fatty liver Female Females Food and nutrition glucose Health aspects Homeostasis Insulin Insulin resistance Laboratory animals Lactation Leptin Leptin - metabolism lipid content Lipids Liver Male Males maternal nutrition Maternal Nutritional Physiological Phenomena Metabolism Mothers Obesity Obesity - metabolism Offspring Overweight Parturition perinatal period Physiological aspects Physiological effects Pregnancy Pregnant women Prenatal Exposure Delayed Effects Prenatal influences progeny Rats Risk factors Sterols Suckling behavior Transcription factors Variance analysis Weaning Western diets Womens health |
| title | Influence of Maternal Metabolic Status and Diet during the Perinatal Period on the Metabolic Programming by Leptin Ingested during the Suckling Period in Rats |
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