HLA-haploidentical hematopoietic stem cells transplantation with regulatory and conventional T-cell adoptive immunotherapy in pediatric patients with very high-risk acute leukemia

Allogeneic hematopoietic stem cell transplantation (HSCT) is still needed for many children with very high-risk acute leukemia. An HLA-haploidentical family donor is a suitable option for those without an HLA-matched donor. Here we present outcomes of a novel HLA-haploidentical HSCT (haplo-HSCT) str...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2023-05, Vol.58 (5), p.526-533
Hauptverfasser:	Massei, M. S., Capolsini, I., Mastrodicasa, E., Perruccio, K., Arcioni, F., Cerri, C., Gurdo, G., Sciabolacci, S., Falzetti, F., Zei, T., Iacucci Ostini, R., Brogna, M., Panizza, B. M., Saldi, S., Merluzzi, M., Tognellini, R., Marchesi, M., Minelli, O., Aristei, C., Velardi, A., Pierini, A., Ruggeri, L., Martelli, M. F., Carotti, A., Caniglia, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 14/1 631/250/1904 692/308/575 Acute lymphoblastic leukemia Acute myeloid leukemia Adolescent Adoptive immunotherapy CD25 antigen CD34 antigen CD4 antigen Cell Biology Child Cyclophosphamide Fludarabine Foxp3 protein Graft vs Host Disease - etiology Graft-versus-host reaction Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cells Histocompatibility antigen HLA Humans Immunoregulation Immunotherapy Immunotherapy, Adoptive - adverse effects Internal Medicine Irradiation Leukemia Leukemia, Myeloid, Acute - complications Lymphatic leukemia Lymphocytes Lymphocytes T Medicine Medicine & Public Health Patients Pediatrics Public Health Radiation Risk Stem cell transplantation Stem Cells Strategy Thymus Transplantation Transplantation Conditioning - adverse effects
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