Oxidation State in Peritoneal Dialysis in Patients with Type 2 Diabetes Mellitus
End-stage renal disease (ESRD) progression is closely related to oxidative stress (OS). The study objective was to determine the oxidant and antioxidant status in peritoneal dialysis (PD) patients with type 2 diabetes mellitus (DM). An analytical cross-sectional study from the PD program was carried...
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| Veröffentlicht in: | International journal of molecular sciences 2023-01, Vol.24 (3), p.2669 |
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| creator | Pazarín-Villaseñor, Leonardo García-Salas, Yessica Yanowsky-Escatell, Francisco Gerardo Pacheco-Moisés, Fermín Paul Andrade-Sierra, Jorge Campos-Bayardo, Tannia Isabel Román-Rojas, Daniel García-Sánchez, Andrés Miranda-Díaz, Alejandra Guillermina |
| description | End-stage renal disease (ESRD) progression is closely related to oxidative stress (OS). The study objective was to determine the oxidant and antioxidant status in peritoneal dialysis (PD) patients with type 2 diabetes mellitus (DM). An analytical cross-sectional study from the PD program was carried out with 62 patients, 22 with and 40 without DM. Lipoperoxides (LPO) levels in patients with DM, 3.74 ± 1.09 mM/L, and without DM, 3.87 ± 0.84 mM/L were found to increase compared to healthy controls (HC) 3.05 ± 0.58 mM/L (
= 0.006). The levels of the oxidative DNA damage marker (8-OH-dG) were found to be significantly increased in patients with DM, 1.71 ng/mL (0.19-71.92) and without DM, 1.05 ng/mL (0.16-68.80) front to 0.15 ng/mL (0.15-0.1624) of HC (
= 0.001). The antioxidant enzyme superoxide dismutase (SOD) activity was found to be significantly increased in patients with DM, 0.37 ± 0.15 U/mL, and without DM, 0.37 ± 0.17 compared to HC, 0.23 ± 0.05 U/mL (
= 0.038). The activity of the enzyme glutathione peroxidase (GPx) showed a significant increase (
< 0.001) in patients with DM, 3.56 ± 2.18 nmol/min/mL, and without DM, 3.28 ± 1.46 nmol/min/mL, contrary to the activity obtained in HC, 1.55 ± 0.34 nmol/min/mL. In conclusion, we found an imbalance of oxidative status in patients undergoing PD with and without DM through the significant increase in LPO oxidants and the marker of oxidative damage in DNA. The activity of the antioxidant enzymes SOD and GPx were significantly increased in patients with and without DM undergoing PD, possibly in an attempt to compensate for the deregulation of oxidants. Antioxidant enzymes could be promising therapeutic strategies as a complement to the management of chronic kidney diseases. |
| doi_str_mv | 10.3390/ijms24032669 |
| format | Article |
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= 0.006). The levels of the oxidative DNA damage marker (8-OH-dG) were found to be significantly increased in patients with DM, 1.71 ng/mL (0.19-71.92) and without DM, 1.05 ng/mL (0.16-68.80) front to 0.15 ng/mL (0.15-0.1624) of HC (
= 0.001). The antioxidant enzyme superoxide dismutase (SOD) activity was found to be significantly increased in patients with DM, 0.37 ± 0.15 U/mL, and without DM, 0.37 ± 0.17 compared to HC, 0.23 ± 0.05 U/mL (
= 0.038). The activity of the enzyme glutathione peroxidase (GPx) showed a significant increase (
< 0.001) in patients with DM, 3.56 ± 2.18 nmol/min/mL, and without DM, 3.28 ± 1.46 nmol/min/mL, contrary to the activity obtained in HC, 1.55 ± 0.34 nmol/min/mL. In conclusion, we found an imbalance of oxidative status in patients undergoing PD with and without DM through the significant increase in LPO oxidants and the marker of oxidative damage in DNA. The activity of the antioxidant enzymes SOD and GPx were significantly increased in patients with and without DM undergoing PD, possibly in an attempt to compensate for the deregulation of oxidants. Antioxidant enzymes could be promising therapeutic strategies as a complement to the management of chronic kidney diseases.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24032669</identifier><identifier>PMID: 36768992</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antioxidants ; Antioxidants - metabolism ; Body mass index ; Creatinine ; Cross-Sectional Studies ; Deregulation ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 ; DNA damage ; DNA repair ; End-stage renal disease ; Enzymes ; Glucose ; Glutathione peroxidase ; Glutathione Peroxidase - metabolism ; Health care ; Hemodialysis ; Humans ; Hyperglycemia ; Hypertension ; Kidney diseases ; Lipid Peroxides ; Malnutrition ; Metabolism ; Metabolites ; Mortality ; Nitric oxide ; Overweight ; Oxidants ; Oxidation ; Oxidative Stress ; Oxidizing agents ; Peritoneal Dialysis ; Peritoneum ; Peroxidase ; Potassium ; Proteins ; Regression analysis ; Superoxide Dismutase - metabolism ; Transplants & implants</subject><ispartof>International journal of molecular sciences, 2023-01, Vol.24 (3), p.2669</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-cd53fffdc2596432e9641e40358512a494fcb8613dcf3561f121d3da429e24a53</citedby><cites>FETCH-LOGICAL-c412t-cd53fffdc2596432e9641e40358512a494fcb8613dcf3561f121d3da429e24a53</cites><orcidid>0000-0002-0621-5075 ; 0000-0001-8755-9058 ; 0000-0002-1663-8223 ; 0000-0002-4435-9686 ; 0000-0002-0924-4365</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916940/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916940/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36768992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pazarín-Villaseñor, Leonardo</creatorcontrib><creatorcontrib>García-Salas, Yessica</creatorcontrib><creatorcontrib>Yanowsky-Escatell, Francisco Gerardo</creatorcontrib><creatorcontrib>Pacheco-Moisés, Fermín Paul</creatorcontrib><creatorcontrib>Andrade-Sierra, Jorge</creatorcontrib><creatorcontrib>Campos-Bayardo, Tannia Isabel</creatorcontrib><creatorcontrib>Román-Rojas, Daniel</creatorcontrib><creatorcontrib>García-Sánchez, Andrés</creatorcontrib><creatorcontrib>Miranda-Díaz, Alejandra Guillermina</creatorcontrib><title>Oxidation State in Peritoneal Dialysis in Patients with Type 2 Diabetes Mellitus</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>End-stage renal disease (ESRD) progression is closely related to oxidative stress (OS). The study objective was to determine the oxidant and antioxidant status in peritoneal dialysis (PD) patients with type 2 diabetes mellitus (DM). An analytical cross-sectional study from the PD program was carried out with 62 patients, 22 with and 40 without DM. Lipoperoxides (LPO) levels in patients with DM, 3.74 ± 1.09 mM/L, and without DM, 3.87 ± 0.84 mM/L were found to increase compared to healthy controls (HC) 3.05 ± 0.58 mM/L (
= 0.006). The levels of the oxidative DNA damage marker (8-OH-dG) were found to be significantly increased in patients with DM, 1.71 ng/mL (0.19-71.92) and without DM, 1.05 ng/mL (0.16-68.80) front to 0.15 ng/mL (0.15-0.1624) of HC (
= 0.001). The antioxidant enzyme superoxide dismutase (SOD) activity was found to be significantly increased in patients with DM, 0.37 ± 0.15 U/mL, and without DM, 0.37 ± 0.17 compared to HC, 0.23 ± 0.05 U/mL (
= 0.038). The activity of the enzyme glutathione peroxidase (GPx) showed a significant increase (
< 0.001) in patients with DM, 3.56 ± 2.18 nmol/min/mL, and without DM, 3.28 ± 1.46 nmol/min/mL, contrary to the activity obtained in HC, 1.55 ± 0.34 nmol/min/mL. In conclusion, we found an imbalance of oxidative status in patients undergoing PD with and without DM through the significant increase in LPO oxidants and the marker of oxidative damage in DNA. The activity of the antioxidant enzymes SOD and GPx were significantly increased in patients with and without DM undergoing PD, possibly in an attempt to compensate for the deregulation of oxidants. Antioxidant enzymes could be promising therapeutic strategies as a complement to the management of chronic kidney diseases.</description><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Body mass index</subject><subject>Creatinine</subject><subject>Cross-Sectional Studies</subject><subject>Deregulation</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2</subject><subject>DNA damage</subject><subject>DNA repair</subject><subject>End-stage renal disease</subject><subject>Enzymes</subject><subject>Glucose</subject><subject>Glutathione peroxidase</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Health care</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hypertension</subject><subject>Kidney diseases</subject><subject>Lipid Peroxides</subject><subject>Malnutrition</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Mortality</subject><subject>Nitric oxide</subject><subject>Overweight</subject><subject>Oxidants</subject><subject>Oxidation</subject><subject>Oxidative Stress</subject><subject>Oxidizing agents</subject><subject>Peritoneal Dialysis</subject><subject>Peritoneum</subject><subject>Peroxidase</subject><subject>Potassium</subject><subject>Proteins</subject><subject>Regression analysis</subject><subject>Superoxide Dismutase - 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metabolism</topic><topic>Body mass index</topic><topic>Creatinine</topic><topic>Cross-Sectional Studies</topic><topic>Deregulation</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2</topic><topic>DNA damage</topic><topic>DNA repair</topic><topic>End-stage renal disease</topic><topic>Enzymes</topic><topic>Glucose</topic><topic>Glutathione peroxidase</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Health care</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hypertension</topic><topic>Kidney diseases</topic><topic>Lipid Peroxides</topic><topic>Malnutrition</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Mortality</topic><topic>Nitric oxide</topic><topic>Overweight</topic><topic>Oxidants</topic><topic>Oxidation</topic><topic>Oxidative Stress</topic><topic>Oxidizing agents</topic><topic>Peritoneal Dialysis</topic><topic>Peritoneum</topic><topic>Peroxidase</topic><topic>Potassium</topic><topic>Proteins</topic><topic>Regression analysis</topic><topic>Superoxide Dismutase - 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The study objective was to determine the oxidant and antioxidant status in peritoneal dialysis (PD) patients with type 2 diabetes mellitus (DM). An analytical cross-sectional study from the PD program was carried out with 62 patients, 22 with and 40 without DM. Lipoperoxides (LPO) levels in patients with DM, 3.74 ± 1.09 mM/L, and without DM, 3.87 ± 0.84 mM/L were found to increase compared to healthy controls (HC) 3.05 ± 0.58 mM/L (
= 0.006). The levels of the oxidative DNA damage marker (8-OH-dG) were found to be significantly increased in patients with DM, 1.71 ng/mL (0.19-71.92) and without DM, 1.05 ng/mL (0.16-68.80) front to 0.15 ng/mL (0.15-0.1624) of HC (
= 0.001). The antioxidant enzyme superoxide dismutase (SOD) activity was found to be significantly increased in patients with DM, 0.37 ± 0.15 U/mL, and without DM, 0.37 ± 0.17 compared to HC, 0.23 ± 0.05 U/mL (
= 0.038). The activity of the enzyme glutathione peroxidase (GPx) showed a significant increase (
< 0.001) in patients with DM, 3.56 ± 2.18 nmol/min/mL, and without DM, 3.28 ± 1.46 nmol/min/mL, contrary to the activity obtained in HC, 1.55 ± 0.34 nmol/min/mL. In conclusion, we found an imbalance of oxidative status in patients undergoing PD with and without DM through the significant increase in LPO oxidants and the marker of oxidative damage in DNA. The activity of the antioxidant enzymes SOD and GPx were significantly increased in patients with and without DM undergoing PD, possibly in an attempt to compensate for the deregulation of oxidants. Antioxidant enzymes could be promising therapeutic strategies as a complement to the management of chronic kidney diseases.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36768992</pmid><doi>10.3390/ijms24032669</doi><orcidid>https://orcid.org/0000-0002-0621-5075</orcidid><orcidid>https://orcid.org/0000-0001-8755-9058</orcidid><orcidid>https://orcid.org/0000-0002-1663-8223</orcidid><orcidid>https://orcid.org/0000-0002-4435-9686</orcidid><orcidid>https://orcid.org/0000-0002-0924-4365</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Antioxidants - metabolism Body mass index Creatinine Cross-Sectional Studies Deregulation Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 DNA damage DNA repair End-stage renal disease Enzymes Glucose Glutathione peroxidase Glutathione Peroxidase - metabolism Health care Hemodialysis Humans Hyperglycemia Hypertension Kidney diseases Lipid Peroxides Malnutrition Metabolism Metabolites Mortality Nitric oxide Overweight Oxidants Oxidation Oxidative Stress Oxidizing agents Peritoneal Dialysis Peritoneum Peroxidase Potassium Proteins Regression analysis Superoxide Dismutase - metabolism Transplants & implants |
| title | Oxidation State in Peritoneal Dialysis in Patients with Type 2 Diabetes Mellitus |
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