Effects of Green Tea Polyphenol Epigallocatechin-3-Gallate on Markers of Inflammation and Fibrosis in a Rat Model of Pulmonary Silicosis
Inhalation of silica particles causes inflammatory changes leading to fibrotizing silicosis. Considering a lack of effective therapy, and a growing information on the wide actions of green tea polyphenols, particularly epigallocatechin-3-gallate (EGCG), the aim of this study was to evaluate the earl...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2023-01, Vol.24 (3), p.1857 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | 1857 |
| container_title | International journal of molecular sciences |
| container_volume | 24 |
| creator | Adamcakova, Jana Balentova, Sona Barosova, Romana Hanusrichterova, Juliana Mikolka, Pavol Prso, Kristian Mokry, Juraj Tatarkova, Zuzana Kalenska, Dagmar Mokra, Daniela |
| description | Inhalation of silica particles causes inflammatory changes leading to fibrotizing silicosis. Considering a lack of effective therapy, and a growing information on the wide actions of green tea polyphenols, particularly epigallocatechin-3-gallate (EGCG), the aim of this study was to evaluate the early effects of EGCG on markers of inflammation and lung fibrosis in silicotic rats. The silicosis model was induced by a single transoral intratracheal instillation of silica (50 mg/mL/animal), while controls received an equivalent volume of saline. The treatment with intraperitoneal EGCG (20 mg/kg, or saline in controls) was initiated the next day after silica instillation and was given twice a week. Animals were euthanized 14 or 28 days after the treatment onset, and the total and differential counts of leukocytes in the blood and bronchoalveolar lavage fluid (BALF), wet/dry lung weight ratio, and markers of inflammation, oxidative stress, and fibrosis in the lung were determined. The presence of collagen and smooth muscle mass in the walls of bronchioles and lung vessels was investigated immunohistochemically. Early treatment with EGCG showed some potential to alleviate inflammation, and a trend to decrease oxidative stress-induced changes, including apoptosis, and a prevention of fibrotic changes in the bronchioles and pulmonary vessels. However, further investigations should be undertaken to elucidate the effects of EGCG in the lung silicosis model in more detail. In addition, because of insufficient data from EGCG delivery in silicosis, the positive and eventual adverse effects of this herbal compound should be carefully studied before any preventive use or therapy with EGCG may be recommended. |
| doi_str_mv | 10.3390/ijms24031857 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9916388</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2775617609</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-fd4a694fbd2bfb03f05cc059606b314e113f3a340c9beaed4c4b5471f168c2e63</originalsourceid><addsrcrecordid>eNpdkU9v1DAQxS0EoqVw44wsceFAwP_ixBckVG2XSq2ooJwtxxl3vTj2YidI_QZ8bLy0VAsn-41_fpqZh9BLSt5xrsh7v50KE4TTvu0eoWMqGGsIkd3jg_sRelbKlhDGWaueoiMuO9nTTh2jXyvnwM4FJ4fXGSDiazD4KoXb3QZiCni18zcmhGTNDHbjY8ObddVV4RTxpcnfIf_5fR5dMNNkZl_rJo74zA85FV-wrxp_MTO-TCOEPXu1hClFk2_xVx-83VPP0RNnQoEX9-cJ-na2uj791Fx8Xp-ffrxorKBsbtwojFTCDSMb3EC4I621pFWSyIFTAZRyxw0XxKoBDIzCiqEVHXVU9paB5Cfow53vbhkmGC3EOZugd9lPtR-djNf_vkS_0Tfpp1aKSt731eDNvUFOPxYos558sVBXEiEtRbOuayXtJFEVff0fuk1LjnW8PSUUbWUrKvX2jrJ1XSWDe2iGEr2PWB9GXPFXhwM8wH8z5b8BmqGkIw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2774915654</pqid></control><display><type>article</type><title>Effects of Green Tea Polyphenol Epigallocatechin-3-Gallate on Markers of Inflammation and Fibrosis in a Rat Model of Pulmonary Silicosis</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Adamcakova, Jana ; Balentova, Sona ; Barosova, Romana ; Hanusrichterova, Juliana ; Mikolka, Pavol ; Prso, Kristian ; Mokry, Juraj ; Tatarkova, Zuzana ; Kalenska, Dagmar ; Mokra, Daniela</creator><creatorcontrib>Adamcakova, Jana ; Balentova, Sona ; Barosova, Romana ; Hanusrichterova, Juliana ; Mikolka, Pavol ; Prso, Kristian ; Mokry, Juraj ; Tatarkova, Zuzana ; Kalenska, Dagmar ; Mokra, Daniela</creatorcontrib><description>Inhalation of silica particles causes inflammatory changes leading to fibrotizing silicosis. Considering a lack of effective therapy, and a growing information on the wide actions of green tea polyphenols, particularly epigallocatechin-3-gallate (EGCG), the aim of this study was to evaluate the early effects of EGCG on markers of inflammation and lung fibrosis in silicotic rats. The silicosis model was induced by a single transoral intratracheal instillation of silica (50 mg/mL/animal), while controls received an equivalent volume of saline. The treatment with intraperitoneal EGCG (20 mg/kg, or saline in controls) was initiated the next day after silica instillation and was given twice a week. Animals were euthanized 14 or 28 days after the treatment onset, and the total and differential counts of leukocytes in the blood and bronchoalveolar lavage fluid (BALF), wet/dry lung weight ratio, and markers of inflammation, oxidative stress, and fibrosis in the lung were determined. The presence of collagen and smooth muscle mass in the walls of bronchioles and lung vessels was investigated immunohistochemically. Early treatment with EGCG showed some potential to alleviate inflammation, and a trend to decrease oxidative stress-induced changes, including apoptosis, and a prevention of fibrotic changes in the bronchioles and pulmonary vessels. However, further investigations should be undertaken to elucidate the effects of EGCG in the lung silicosis model in more detail. In addition, because of insufficient data from EGCG delivery in silicosis, the positive and eventual adverse effects of this herbal compound should be carefully studied before any preventive use or therapy with EGCG may be recommended.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24031857</identifier><identifier>PMID: 36768179</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Antioxidants ; Apoptosis ; Bronchus ; Catechin - pharmacology ; Catechin - therapeutic use ; Collagen ; Cytokines ; Disease ; Enzymes ; Epigallocatechin gallate ; Fibroblasts ; Fibrosis ; Green tea ; Inflammation ; Inflammation - drug therapy ; Inflammation - pathology ; Inhalation ; Kinases ; Lavage ; Leukocytes ; Lung - pathology ; Lungs ; Lymphocytes ; Metabolism ; Muscles ; Neutrophils ; Oxidation ; Oxidative stress ; Polyphenols ; Polyphenols - pharmacology ; Polyphenols - therapeutic use ; Proteins ; Rats ; Respiration ; Silica ; Silicon Dioxide ; Silicosis ; Silicosis - drug therapy ; Silicosis - pathology ; Smooth muscle ; Tea ; Tea - chemistry ; Trachea ; Tumor necrosis factor-TNF</subject><ispartof>International journal of molecular sciences, 2023-01, Vol.24 (3), p.1857</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-fd4a694fbd2bfb03f05cc059606b314e113f3a340c9beaed4c4b5471f168c2e63</citedby><cites>FETCH-LOGICAL-c412t-fd4a694fbd2bfb03f05cc059606b314e113f3a340c9beaed4c4b5471f168c2e63</cites><orcidid>0000-0001-7756-5569 ; 0000-0001-8485-4748 ; 0000-0003-4125-3568 ; 0000-0001-5885-6360</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916388/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9916388/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36768179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adamcakova, Jana</creatorcontrib><creatorcontrib>Balentova, Sona</creatorcontrib><creatorcontrib>Barosova, Romana</creatorcontrib><creatorcontrib>Hanusrichterova, Juliana</creatorcontrib><creatorcontrib>Mikolka, Pavol</creatorcontrib><creatorcontrib>Prso, Kristian</creatorcontrib><creatorcontrib>Mokry, Juraj</creatorcontrib><creatorcontrib>Tatarkova, Zuzana</creatorcontrib><creatorcontrib>Kalenska, Dagmar</creatorcontrib><creatorcontrib>Mokra, Daniela</creatorcontrib><title>Effects of Green Tea Polyphenol Epigallocatechin-3-Gallate on Markers of Inflammation and Fibrosis in a Rat Model of Pulmonary Silicosis</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Inhalation of silica particles causes inflammatory changes leading to fibrotizing silicosis. Considering a lack of effective therapy, and a growing information on the wide actions of green tea polyphenols, particularly epigallocatechin-3-gallate (EGCG), the aim of this study was to evaluate the early effects of EGCG on markers of inflammation and lung fibrosis in silicotic rats. The silicosis model was induced by a single transoral intratracheal instillation of silica (50 mg/mL/animal), while controls received an equivalent volume of saline. The treatment with intraperitoneal EGCG (20 mg/kg, or saline in controls) was initiated the next day after silica instillation and was given twice a week. Animals were euthanized 14 or 28 days after the treatment onset, and the total and differential counts of leukocytes in the blood and bronchoalveolar lavage fluid (BALF), wet/dry lung weight ratio, and markers of inflammation, oxidative stress, and fibrosis in the lung were determined. The presence of collagen and smooth muscle mass in the walls of bronchioles and lung vessels was investigated immunohistochemically. Early treatment with EGCG showed some potential to alleviate inflammation, and a trend to decrease oxidative stress-induced changes, including apoptosis, and a prevention of fibrotic changes in the bronchioles and pulmonary vessels. However, further investigations should be undertaken to elucidate the effects of EGCG in the lung silicosis model in more detail. In addition, because of insufficient data from EGCG delivery in silicosis, the positive and eventual adverse effects of this herbal compound should be carefully studied before any preventive use or therapy with EGCG may be recommended.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Bronchus</subject><subject>Catechin - pharmacology</subject><subject>Catechin - therapeutic use</subject><subject>Collagen</subject><subject>Cytokines</subject><subject>Disease</subject><subject>Enzymes</subject><subject>Epigallocatechin gallate</subject><subject>Fibroblasts</subject><subject>Fibrosis</subject><subject>Green tea</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - pathology</subject><subject>Inhalation</subject><subject>Kinases</subject><subject>Lavage</subject><subject>Leukocytes</subject><subject>Lung - pathology</subject><subject>Lungs</subject><subject>Lymphocytes</subject><subject>Metabolism</subject><subject>Muscles</subject><subject>Neutrophils</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Polyphenols</subject><subject>Polyphenols - pharmacology</subject><subject>Polyphenols - therapeutic use</subject><subject>Proteins</subject><subject>Rats</subject><subject>Respiration</subject><subject>Silica</subject><subject>Silicon Dioxide</subject><subject>Silicosis</subject><subject>Silicosis - drug therapy</subject><subject>Silicosis - pathology</subject><subject>Smooth muscle</subject><subject>Tea</subject><subject>Tea - chemistry</subject><subject>Trachea</subject><subject>Tumor necrosis factor-TNF</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU9v1DAQxS0EoqVw44wsceFAwP_ixBckVG2XSq2ooJwtxxl3vTj2YidI_QZ8bLy0VAsn-41_fpqZh9BLSt5xrsh7v50KE4TTvu0eoWMqGGsIkd3jg_sRelbKlhDGWaueoiMuO9nTTh2jXyvnwM4FJ4fXGSDiazD4KoXb3QZiCni18zcmhGTNDHbjY8ObddVV4RTxpcnfIf_5fR5dMNNkZl_rJo74zA85FV-wrxp_MTO-TCOEPXu1hClFk2_xVx-83VPP0RNnQoEX9-cJ-na2uj791Fx8Xp-ffrxorKBsbtwojFTCDSMb3EC4I621pFWSyIFTAZRyxw0XxKoBDIzCiqEVHXVU9paB5Cfow53vbhkmGC3EOZugd9lPtR-djNf_vkS_0Tfpp1aKSt731eDNvUFOPxYos558sVBXEiEtRbOuayXtJFEVff0fuk1LjnW8PSUUbWUrKvX2jrJ1XSWDe2iGEr2PWB9GXPFXhwM8wH8z5b8BmqGkIw</recordid><startdate>20230117</startdate><enddate>20230117</enddate><creator>Adamcakova, Jana</creator><creator>Balentova, Sona</creator><creator>Barosova, Romana</creator><creator>Hanusrichterova, Juliana</creator><creator>Mikolka, Pavol</creator><creator>Prso, Kristian</creator><creator>Mokry, Juraj</creator><creator>Tatarkova, Zuzana</creator><creator>Kalenska, Dagmar</creator><creator>Mokra, Daniela</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7756-5569</orcidid><orcidid>https://orcid.org/0000-0001-8485-4748</orcidid><orcidid>https://orcid.org/0000-0003-4125-3568</orcidid><orcidid>https://orcid.org/0000-0001-5885-6360</orcidid></search><sort><creationdate>20230117</creationdate><title>Effects of Green Tea Polyphenol Epigallocatechin-3-Gallate on Markers of Inflammation and Fibrosis in a Rat Model of Pulmonary Silicosis</title><author>Adamcakova, Jana ; Balentova, Sona ; Barosova, Romana ; Hanusrichterova, Juliana ; Mikolka, Pavol ; Prso, Kristian ; Mokry, Juraj ; Tatarkova, Zuzana ; Kalenska, Dagmar ; Mokra, Daniela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-fd4a694fbd2bfb03f05cc059606b314e113f3a340c9beaed4c4b5471f168c2e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Bronchus</topic><topic>Catechin - pharmacology</topic><topic>Catechin - therapeutic use</topic><topic>Collagen</topic><topic>Cytokines</topic><topic>Disease</topic><topic>Enzymes</topic><topic>Epigallocatechin gallate</topic><topic>Fibroblasts</topic><topic>Fibrosis</topic><topic>Green tea</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - pathology</topic><topic>Inhalation</topic><topic>Kinases</topic><topic>Lavage</topic><topic>Leukocytes</topic><topic>Lung - pathology</topic><topic>Lungs</topic><topic>Lymphocytes</topic><topic>Metabolism</topic><topic>Muscles</topic><topic>Neutrophils</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Polyphenols</topic><topic>Polyphenols - pharmacology</topic><topic>Polyphenols - therapeutic use</topic><topic>Proteins</topic><topic>Rats</topic><topic>Respiration</topic><topic>Silica</topic><topic>Silicon Dioxide</topic><topic>Silicosis</topic><topic>Silicosis - drug therapy</topic><topic>Silicosis - pathology</topic><topic>Smooth muscle</topic><topic>Tea</topic><topic>Tea - chemistry</topic><topic>Trachea</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adamcakova, Jana</creatorcontrib><creatorcontrib>Balentova, Sona</creatorcontrib><creatorcontrib>Barosova, Romana</creatorcontrib><creatorcontrib>Hanusrichterova, Juliana</creatorcontrib><creatorcontrib>Mikolka, Pavol</creatorcontrib><creatorcontrib>Prso, Kristian</creatorcontrib><creatorcontrib>Mokry, Juraj</creatorcontrib><creatorcontrib>Tatarkova, Zuzana</creatorcontrib><creatorcontrib>Kalenska, Dagmar</creatorcontrib><creatorcontrib>Mokra, Daniela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adamcakova, Jana</au><au>Balentova, Sona</au><au>Barosova, Romana</au><au>Hanusrichterova, Juliana</au><au>Mikolka, Pavol</au><au>Prso, Kristian</au><au>Mokry, Juraj</au><au>Tatarkova, Zuzana</au><au>Kalenska, Dagmar</au><au>Mokra, Daniela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Green Tea Polyphenol Epigallocatechin-3-Gallate on Markers of Inflammation and Fibrosis in a Rat Model of Pulmonary Silicosis</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2023-01-17</date><risdate>2023</risdate><volume>24</volume><issue>3</issue><spage>1857</spage><pages>1857-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Inhalation of silica particles causes inflammatory changes leading to fibrotizing silicosis. Considering a lack of effective therapy, and a growing information on the wide actions of green tea polyphenols, particularly epigallocatechin-3-gallate (EGCG), the aim of this study was to evaluate the early effects of EGCG on markers of inflammation and lung fibrosis in silicotic rats. The silicosis model was induced by a single transoral intratracheal instillation of silica (50 mg/mL/animal), while controls received an equivalent volume of saline. The treatment with intraperitoneal EGCG (20 mg/kg, or saline in controls) was initiated the next day after silica instillation and was given twice a week. Animals were euthanized 14 or 28 days after the treatment onset, and the total and differential counts of leukocytes in the blood and bronchoalveolar lavage fluid (BALF), wet/dry lung weight ratio, and markers of inflammation, oxidative stress, and fibrosis in the lung were determined. The presence of collagen and smooth muscle mass in the walls of bronchioles and lung vessels was investigated immunohistochemically. Early treatment with EGCG showed some potential to alleviate inflammation, and a trend to decrease oxidative stress-induced changes, including apoptosis, and a prevention of fibrotic changes in the bronchioles and pulmonary vessels. However, further investigations should be undertaken to elucidate the effects of EGCG in the lung silicosis model in more detail. In addition, because of insufficient data from EGCG delivery in silicosis, the positive and eventual adverse effects of this herbal compound should be carefully studied before any preventive use or therapy with EGCG may be recommended.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36768179</pmid><doi>10.3390/ijms24031857</doi><orcidid>https://orcid.org/0000-0001-7756-5569</orcidid><orcidid>https://orcid.org/0000-0001-8485-4748</orcidid><orcidid>https://orcid.org/0000-0003-4125-3568</orcidid><orcidid>https://orcid.org/0000-0001-5885-6360</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2023-01, Vol.24 (3), p.1857 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9916388 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Antioxidants Apoptosis Bronchus Catechin - pharmacology Catechin - therapeutic use Collagen Cytokines Disease Enzymes Epigallocatechin gallate Fibroblasts Fibrosis Green tea Inflammation Inflammation - drug therapy Inflammation - pathology Inhalation Kinases Lavage Leukocytes Lung - pathology Lungs Lymphocytes Metabolism Muscles Neutrophils Oxidation Oxidative stress Polyphenols Polyphenols - pharmacology Polyphenols - therapeutic use Proteins Rats Respiration Silica Silicon Dioxide Silicosis Silicosis - drug therapy Silicosis - pathology Smooth muscle Tea Tea - chemistry Trachea Tumor necrosis factor-TNF |
| title | Effects of Green Tea Polyphenol Epigallocatechin-3-Gallate on Markers of Inflammation and Fibrosis in a Rat Model of Pulmonary Silicosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T18%3A27%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Green%20Tea%20Polyphenol%20Epigallocatechin-3-Gallate%20on%20Markers%20of%20Inflammation%20and%20Fibrosis%20in%20a%20Rat%20Model%20of%20Pulmonary%20Silicosis&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Adamcakova,%20Jana&rft.date=2023-01-17&rft.volume=24&rft.issue=3&rft.spage=1857&rft.pages=1857-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms24031857&rft_dat=%3Cproquest_pubme%3E2775617609%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2774915654&rft_id=info:pmid/36768179&rfr_iscdi=true |