Deletion of Glycogen Synthase Kinase 3 Beta Reprograms NK Cell Metabolism

Loss of cytotoxicity and defective metabolism are linked to glycogen synthase kinase 3 beta (GSK3β) overexpression in natural killer (NK) cells from patients with acute myeloid leukemia or from healthy donors after expansion ex vivo with IL-15. Drug inhibition of GSK3β in these NK cells improves the...

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Veröffentlicht in:	Cancers 2023-01, Vol.15 (3), p.705
Hauptverfasser:	Pereira, Marcelo S F, Sorathia, Kinnari, Sezgin, Yasemin, Thakkar, Aarohi, Maguire, Colin, Collins, Patrick L, Mundy-Bosse, Bethany L, Lee, Dean A, Naeimi Kararoudi, Meisam
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Antibodies B cells Biotechnology industry Blood CD57 antigen Cell metabolism Cell proliferation Cells CRISPR Cytokines Cytotoxicity Gene expression Genes Genetic aspects Glucose metabolism Glycogen Glycogen synthase kinase 3 Health aspects Interleukin 15 Interleukin 21 Killer cells Kinases Leukemia Metabolism Mitochondria Natural killer cells Phenotypes Physiological aspects Protein kinases RNA RNA processing rRNA Software Synthesis
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