Central Compartment Neck Dissection in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: Clinical Considerations
Metastatic lymph node involvement represents the most relevant prognostic factor in head and neck squamous cell carcinomas (HNSCCs), invariably affecting overall survival, disease-specific survival, and relapse-free survival. Among HNSCCs, laryngeal and hypopharyngeal cancers are known to be at high...
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| Veröffentlicht in: | Cancers 2023-01, Vol.15 (3), p.804 |
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| creator | Deganello, Alberto Ruaro, Alessandra Gualtieri, Tommaso Berretti, Giulia Rampinelli, Vittorio Borsetto, Daniele Russo, Sabino Boscolo-Rizzo, Paolo Ferrari, Marco Bussu, Francesco |
| description | Metastatic lymph node involvement represents the most relevant prognostic factor in head and neck squamous cell carcinomas (HNSCCs), invariably affecting overall survival, disease-specific survival, and relapse-free survival. Among HNSCCs, laryngeal and hypopharyngeal cancers are known to be at highest risk to metastasize to the central neck compartment (CNC). However, prevalence and prognostic implications related to the CNC involvement are not well defined yet, and controversies still exist regarding the occult metastasis rate. Guidelines for the management of CNC in laryngeal and hypopharyngeal cancers are vague, resulting in highly variable selection criteria for the central neck dissection among different surgeons and institutions. With this review, the authors intend to reappraise the existing data related to the involvement of CNC in laryngeal and hypopharyngeal malignancies, in the attempt to define the principles of management while highlighting the debated aspects that are lacking in evidence and consensus. Furthermore, as definition and boundaries of the CNC have changed over the years, an up-to-date anatomical-surgical description of the CNC is provided. |
| doi_str_mv | 10.3390/cancers15030804 |
| format | Article |
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Among HNSCCs, laryngeal and hypopharyngeal cancers are known to be at highest risk to metastasize to the central neck compartment (CNC). However, prevalence and prognostic implications related to the CNC involvement are not well defined yet, and controversies still exist regarding the occult metastasis rate. Guidelines for the management of CNC in laryngeal and hypopharyngeal cancers are vague, resulting in highly variable selection criteria for the central neck dissection among different surgeons and institutions. With this review, the authors intend to reappraise the existing data related to the involvement of CNC in laryngeal and hypopharyngeal malignancies, in the attempt to define the principles of management while highlighting the debated aspects that are lacking in evidence and consensus. Furthermore, as definition and boundaries of the CNC have changed over the years, an up-to-date anatomical-surgical description of the CNC is provided.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers15030804</identifier><identifier>PMID: 36765762</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Boundaries ; Cancer ; Care and treatment ; Clinical aspects ; Dissection ; Head and neck carcinoma ; Laryngeal cancer ; Lymph nodes ; Lymphatic system ; Malignancy ; Metastases ; Metastasis ; Methods ; Nerves ; Parathyroid ; Patient outcomes ; Review ; Squamous cell carcinoma ; Statistical significance ; Thyroid gland ; Tumors ; Veins & arteries</subject><ispartof>Cancers, 2023-01, Vol.15 (3), p.804</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-fb70817737fdc4a222bca1294d459c1c75e56982495f3d368cc33fccc9fb594f3</citedby><cites>FETCH-LOGICAL-c488t-fb70817737fdc4a222bca1294d459c1c75e56982495f3d368cc33fccc9fb594f3</cites><orcidid>0000-0002-6467-3090 ; 0000-0002-4023-0121 ; 0000-0001-6261-2772 ; 0000-0002-5080-0212</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913832/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913832/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36765762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deganello, Alberto</creatorcontrib><creatorcontrib>Ruaro, Alessandra</creatorcontrib><creatorcontrib>Gualtieri, Tommaso</creatorcontrib><creatorcontrib>Berretti, Giulia</creatorcontrib><creatorcontrib>Rampinelli, Vittorio</creatorcontrib><creatorcontrib>Borsetto, Daniele</creatorcontrib><creatorcontrib>Russo, Sabino</creatorcontrib><creatorcontrib>Boscolo-Rizzo, Paolo</creatorcontrib><creatorcontrib>Ferrari, Marco</creatorcontrib><creatorcontrib>Bussu, Francesco</creatorcontrib><title>Central Compartment Neck Dissection in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: Clinical Considerations</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Metastatic lymph node involvement represents the most relevant prognostic factor in head and neck squamous cell carcinomas (HNSCCs), invariably affecting overall survival, disease-specific survival, and relapse-free survival. Among HNSCCs, laryngeal and hypopharyngeal cancers are known to be at highest risk to metastasize to the central neck compartment (CNC). However, prevalence and prognostic implications related to the CNC involvement are not well defined yet, and controversies still exist regarding the occult metastasis rate. Guidelines for the management of CNC in laryngeal and hypopharyngeal cancers are vague, resulting in highly variable selection criteria for the central neck dissection among different surgeons and institutions. With this review, the authors intend to reappraise the existing data related to the involvement of CNC in laryngeal and hypopharyngeal malignancies, in the attempt to define the principles of management while highlighting the debated aspects that are lacking in evidence and consensus. Furthermore, as definition and boundaries of the CNC have changed over the years, an up-to-date anatomical-surgical description of the CNC is provided.</description><subject>Boundaries</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Clinical aspects</subject><subject>Dissection</subject><subject>Head and neck carcinoma</subject><subject>Laryngeal cancer</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Malignancy</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Methods</subject><subject>Nerves</subject><subject>Parathyroid</subject><subject>Patient outcomes</subject><subject>Review</subject><subject>Squamous cell carcinoma</subject><subject>Statistical significance</subject><subject>Thyroid gland</subject><subject>Tumors</subject><subject>Veins & arteries</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1v3CAQhq2qURMlOfdWWeqll034xvRQKXLzUWnVHtqeETuGDakNDtiR8u_LZtPVJiocgOGZl3nRVNV7jM4oVegcTACbMuaIogaxN9URQZIshFDs7d7-sDrN-Q6VQSmWQr6rDqmQgktBjqqptWFKpq_bOIwmTUM51t8t_Km_-pwtTD6G2od6adJjWNsCmtDVN49jHG93oZ_3sxninOvW9kXJJPAhDuZz3fY-eHhSD9l3NpmNXj6pDpzpsz19Xo-r31eXv9qbxfLH9bf2YrkA1jTTwq0karCUVLoOmCGErMBgoljHuAIMklsuVEOY4o52VDQAlDoAUG7FFXP0uPqy1R3n1WA72FrVY_JDqV1H4_XLm-Bv9To-aKUwbSgpAp-eBVK8n22e9OAzFJMm2OJXEym5ILyUWNCPr9C7OKdQ7G2o4odjtketTW-1Dy6Wd2Ejqi8kowipBvNCnf2HKrOzg4cYrPMl_iLhfJsAKeacrNt5xEhvekW_6pWS8WH_a3b8v86gfwFf_rwS</recordid><startdate>20230128</startdate><enddate>20230128</enddate><creator>Deganello, Alberto</creator><creator>Ruaro, Alessandra</creator><creator>Gualtieri, Tommaso</creator><creator>Berretti, Giulia</creator><creator>Rampinelli, Vittorio</creator><creator>Borsetto, Daniele</creator><creator>Russo, Sabino</creator><creator>Boscolo-Rizzo, Paolo</creator><creator>Ferrari, Marco</creator><creator>Bussu, Francesco</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6467-3090</orcidid><orcidid>https://orcid.org/0000-0002-4023-0121</orcidid><orcidid>https://orcid.org/0000-0001-6261-2772</orcidid><orcidid>https://orcid.org/0000-0002-5080-0212</orcidid></search><sort><creationdate>20230128</creationdate><title>Central Compartment Neck Dissection in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: Clinical Considerations</title><author>Deganello, Alberto ; 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Among HNSCCs, laryngeal and hypopharyngeal cancers are known to be at highest risk to metastasize to the central neck compartment (CNC). However, prevalence and prognostic implications related to the CNC involvement are not well defined yet, and controversies still exist regarding the occult metastasis rate. Guidelines for the management of CNC in laryngeal and hypopharyngeal cancers are vague, resulting in highly variable selection criteria for the central neck dissection among different surgeons and institutions. With this review, the authors intend to reappraise the existing data related to the involvement of CNC in laryngeal and hypopharyngeal malignancies, in the attempt to define the principles of management while highlighting the debated aspects that are lacking in evidence and consensus. Furthermore, as definition and boundaries of the CNC have changed over the years, an up-to-date anatomical-surgical description of the CNC is provided.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36765762</pmid><doi>10.3390/cancers15030804</doi><orcidid>https://orcid.org/0000-0002-6467-3090</orcidid><orcidid>https://orcid.org/0000-0002-4023-0121</orcidid><orcidid>https://orcid.org/0000-0001-6261-2772</orcidid><orcidid>https://orcid.org/0000-0002-5080-0212</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Boundaries Cancer Care and treatment Clinical aspects Dissection Head and neck carcinoma Laryngeal cancer Lymph nodes Lymphatic system Malignancy Metastases Metastasis Methods Nerves Parathyroid Patient outcomes Review Squamous cell carcinoma Statistical significance Thyroid gland Tumors Veins & arteries |
| title | Central Compartment Neck Dissection in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: Clinical Considerations |
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