Number of Local Regional Therapies for Hepatocellular Carcinoma and Peri-Operative Outcomes after Liver Transplantation

The wait times for patients with hepatocellular carcinoma (HCC) listed for liver transplant are longer than ever, which has led to an increased reliance on the use of pre-operative LRTs. The impact that multiple rounds of LRTs have on peri-operative outcomes following transplant is unknown. This was...

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Veröffentlicht in:Cancers 2023-01, Vol.15 (3), p.620
Hauptverfasser: Brown, Audrey E, Shui, Amy M, Adelmann, Dieter, Mehta, Neil, Roll, Garrett R, Hirose, Ryutaro, Syed, Shareef M
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container_issue 3
container_start_page 620
container_title Cancers
container_volume 15
creator Brown, Audrey E
Shui, Amy M
Adelmann, Dieter
Mehta, Neil
Roll, Garrett R
Hirose, Ryutaro
Syed, Shareef M
description The wait times for patients with hepatocellular carcinoma (HCC) listed for liver transplant are longer than ever, which has led to an increased reliance on the use of pre-operative LRTs. The impact that multiple rounds of LRTs have on peri-operative outcomes following transplant is unknown. This was a retrospective single center analysis of 298 consecutive patients with HCC who underwent liver transplant (January 2017 to May 2021). The data was obtained from two institution-specific databases and the TransQIP database. Of the 298 patients, 27 (9.1%) underwent no LRTs, 156 (52.4%) underwent 1-2 LRTs, and 115 (38.6%) underwent ≥3 LRTs prior to LT. The patients with ≥3 LRTs had a significantly higher rate of bile leak compared to patients who received 1-2 LRTs (7.0 vs. 1.3%, = 0.014). Unadjusted and adjusted regression analyses demonstrated a significant association between the total number of LRTs administered and bile leak, but not rates of overall biliary complications. The total number of LRTs was not significantly associated with any other peri-operative or post-operative outcome measure. These findings support the aggressive use of LRTs to control HCC in patients awaiting liver transplant, with further evaluation needed to confirm the biliary leak findings.
doi_str_mv 10.3390/cancers15030620
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source PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Ablation
Bile
Care and treatment
Hepatocellular carcinoma
Hepatoma
Ischemia
Liver
Liver cancer
Liver transplantation
Liver transplants
Methods
Patient outcomes
Patients
Preoperative care
Regression analysis
Thrombosis
Transplantation
title Number of Local Regional Therapies for Hepatocellular Carcinoma and Peri-Operative Outcomes after Liver Transplantation
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