Priming of Colorectal Tumor-Associated Fibroblasts with Zoledronic Acid Conjugated to the Anti-Epidermal Growth Factor Receptor Antibody Cetuximab Elicits Anti-Tumor Vδ2 T Lymphocytes

Tumor-associated fibroblasts (TAF) exert immunosuppressive effects in colorectal carcinoma (CRC), impairing the recognition of tumor cells by effector lymphocytes, including Vδ2 T cells. Herein, we show that CRC-derived TAF can be turned by zoledronic acid (ZA), in soluble form or as antibody-drug c...

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Veröffentlicht in:	Cancers 2023-01, Vol.15 (3), p.610
Hauptverfasser:	Fernandez, Jordi Leonardo Castrillo, Benelli, Roberto, Costa, Delfina, Campioli, Alessio, Tavella, Sara, Zocchi, Maria Raffaella, Poggi, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antibodies Antigens Bone marrow Butyrophilin Cancer Care and treatment CD27 antigen CD45RA antigen Cell activation Cell growth Cell proliferation Colorectal cancer Colorectal carcinoma Cytotoxicity Effector cells Epidermal growth factor Epidermal growth factor receptors Experiments Fibroblasts Flow cytometry Health aspects Immunological memory Invasiveness Lymphocytes Lymphocytes T Memory cells Solid tumors Stroma T cell receptors T cells Tumor cells Tumor microenvironment Zoledronic acid
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