Alterations in Natural Killer Cells in Colorectal Cancer Patients with Stroma AReactive Invasion Front Areas (SARIFA)
Recently, our group introduced Stroma AReactive Invasion Front Areas (SARIFA) as an independent prognostic predictor for a poorer outcome in colon cancer patients, which is probably based on immunologic alterations combined with a direct tumor-adipocyte interaction: the two together reflecting a dis...
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| Veröffentlicht in: | Cancers 2023-02, Vol.15 (3), p.994 |
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| creator | Reitsam, Nic G Märkl, Bruno Dintner, Sebastian Sipos, Eva Grochowski, Przemyslaw Grosser, Bianca Sommer, Florian Eser, Stefan Nerlinger, Pia Jordan, Frank Rank, Andreas Löhr, Phillip Waidhauser, Johanna |
| description | Recently, our group introduced Stroma AReactive Invasion Front Areas (SARIFA) as an independent prognostic predictor for a poorer outcome in colon cancer patients, which is probably based on immunologic alterations combined with a direct tumor-adipocyte interaction: the two together reflecting a distinct tumor biology. Considering it is already known that peripheral immune cells are altered in colorectal cancer (CRC) patients, this study aims to investigate the changes in lymphocyte subsets in SARIFA-positive cases and correlate these changes with the local immune response.
Flow cytometry was performed to analyze B, T, and natural killer (NK) cells in the peripheral blood (PB) of 45 CRC patients. Consecutively, lymphocytes in PB, tumor-infiltrating lymphocytes (TILs), and CD56+ and CD57+ lymphocytes at the invasion front and the tumor center were compared between patients with SARIFA-positive and SARIFA-negative CRCs.
Whereas no differences could be observed regarding most PB lymphocyte populations as well as TILs, NK cells were dramatically reduced in the PB of SARIFA-positive cases. Moreover, CD56 and CD57 immunohistochemistry suggested SARIFA-status-dependent changes regarding NK cells and NK-like lymphocytes in the tumor microenvironment.
This study proves that our newly introduced biomarker, SARIFA, comes along with distinct immunologic alterations, especially regarding NK cells. |
| doi_str_mv | 10.3390/cancers15030994 |
| format | Article |
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Flow cytometry was performed to analyze B, T, and natural killer (NK) cells in the peripheral blood (PB) of 45 CRC patients. Consecutively, lymphocytes in PB, tumor-infiltrating lymphocytes (TILs), and CD56+ and CD57+ lymphocytes at the invasion front and the tumor center were compared between patients with SARIFA-positive and SARIFA-negative CRCs.
Whereas no differences could be observed regarding most PB lymphocyte populations as well as TILs, NK cells were dramatically reduced in the PB of SARIFA-positive cases. Moreover, CD56 and CD57 immunohistochemistry suggested SARIFA-status-dependent changes regarding NK cells and NK-like lymphocytes in the tumor microenvironment.
This study proves that our newly introduced biomarker, SARIFA, comes along with distinct immunologic alterations, especially regarding NK cells.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers15030994</identifier><identifier>PMID: 36765951</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adipocytes ; Automation ; Biological markers ; Biomarkers ; Blood & organ donations ; Carcinoma ; Care and treatment ; CD56 antigen ; CD57 antigen ; Colon cancer ; Colorectal cancer ; Colorectal carcinoma ; Flow cytometry ; Health aspects ; Immune response ; Immunohistochemistry ; Immunotherapy ; Inflammation ; Killer cells ; Lymphocytes ; Medical prognosis ; Metabolism ; Monoclonal antibodies ; Morphology ; Natural killer cells ; Patients ; Peripheral blood ; Stroma ; Surgery ; Tumor microenvironment ; Tumor-infiltrating lymphocytes ; Tumors</subject><ispartof>Cancers, 2023-02, Vol.15 (3), p.994</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-379b494dc59545434ddebe8ca59bffeb2697ac7d6945bc540246fbe554bcdbbc3</citedby><cites>FETCH-LOGICAL-c488t-379b494dc59545434ddebe8ca59bffeb2697ac7d6945bc540246fbe554bcdbbc3</cites><orcidid>0000-0003-3242-3027 ; 0000-0003-4939-279X ; 0000-0002-5636-0043 ; 0000-0002-0070-3158 ; 0000-0002-7704-850X ; 0000-0003-2776-1590</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913252/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913252/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36765951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reitsam, Nic G</creatorcontrib><creatorcontrib>Märkl, Bruno</creatorcontrib><creatorcontrib>Dintner, Sebastian</creatorcontrib><creatorcontrib>Sipos, Eva</creatorcontrib><creatorcontrib>Grochowski, Przemyslaw</creatorcontrib><creatorcontrib>Grosser, Bianca</creatorcontrib><creatorcontrib>Sommer, Florian</creatorcontrib><creatorcontrib>Eser, Stefan</creatorcontrib><creatorcontrib>Nerlinger, Pia</creatorcontrib><creatorcontrib>Jordan, Frank</creatorcontrib><creatorcontrib>Rank, Andreas</creatorcontrib><creatorcontrib>Löhr, Phillip</creatorcontrib><creatorcontrib>Waidhauser, Johanna</creatorcontrib><title>Alterations in Natural Killer Cells in Colorectal Cancer Patients with Stroma AReactive Invasion Front Areas (SARIFA)</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Recently, our group introduced Stroma AReactive Invasion Front Areas (SARIFA) as an independent prognostic predictor for a poorer outcome in colon cancer patients, which is probably based on immunologic alterations combined with a direct tumor-adipocyte interaction: the two together reflecting a distinct tumor biology. Considering it is already known that peripheral immune cells are altered in colorectal cancer (CRC) patients, this study aims to investigate the changes in lymphocyte subsets in SARIFA-positive cases and correlate these changes with the local immune response.
Flow cytometry was performed to analyze B, T, and natural killer (NK) cells in the peripheral blood (PB) of 45 CRC patients. Consecutively, lymphocytes in PB, tumor-infiltrating lymphocytes (TILs), and CD56+ and CD57+ lymphocytes at the invasion front and the tumor center were compared between patients with SARIFA-positive and SARIFA-negative CRCs.
Whereas no differences could be observed regarding most PB lymphocyte populations as well as TILs, NK cells were dramatically reduced in the PB of SARIFA-positive cases. Moreover, CD56 and CD57 immunohistochemistry suggested SARIFA-status-dependent changes regarding NK cells and NK-like lymphocytes in the tumor microenvironment.
This study proves that our newly introduced biomarker, SARIFA, comes along with distinct immunologic alterations, especially regarding NK cells.</description><subject>Adipocytes</subject><subject>Automation</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Blood & organ donations</subject><subject>Carcinoma</subject><subject>Care and treatment</subject><subject>CD56 antigen</subject><subject>CD57 antigen</subject><subject>Colon cancer</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Flow cytometry</subject><subject>Health aspects</subject><subject>Immune response</subject><subject>Immunohistochemistry</subject><subject>Immunotherapy</subject><subject>Inflammation</subject><subject>Killer cells</subject><subject>Lymphocytes</subject><subject>Medical prognosis</subject><subject>Metabolism</subject><subject>Monoclonal antibodies</subject><subject>Morphology</subject><subject>Natural killer cells</subject><subject>Patients</subject><subject>Peripheral blood</subject><subject>Stroma</subject><subject>Surgery</subject><subject>Tumor microenvironment</subject><subject>Tumor-infiltrating 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in Natural Killer Cells in Colorectal Cancer Patients with Stroma AReactive Invasion Front Areas (SARIFA)</title><author>Reitsam, Nic G ; Märkl, Bruno ; Dintner, Sebastian ; Sipos, Eva ; Grochowski, Przemyslaw ; Grosser, Bianca ; Sommer, Florian ; Eser, Stefan ; Nerlinger, Pia ; Jordan, Frank ; Rank, Andreas ; Löhr, Phillip ; Waidhauser, Johanna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-379b494dc59545434ddebe8ca59bffeb2697ac7d6945bc540246fbe554bcdbbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adipocytes</topic><topic>Automation</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Blood & organ donations</topic><topic>Carcinoma</topic><topic>Care and treatment</topic><topic>CD56 antigen</topic><topic>CD57 antigen</topic><topic>Colon cancer</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Flow cytometry</topic><topic>Health aspects</topic><topic>Immune response</topic><topic>Immunohistochemistry</topic><topic>Immunotherapy</topic><topic>Inflammation</topic><topic>Killer cells</topic><topic>Lymphocytes</topic><topic>Medical prognosis</topic><topic>Metabolism</topic><topic>Monoclonal antibodies</topic><topic>Morphology</topic><topic>Natural killer cells</topic><topic>Patients</topic><topic>Peripheral blood</topic><topic>Stroma</topic><topic>Surgery</topic><topic>Tumor microenvironment</topic><topic>Tumor-infiltrating lymphocytes</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reitsam, Nic G</creatorcontrib><creatorcontrib>Märkl, Bruno</creatorcontrib><creatorcontrib>Dintner, Sebastian</creatorcontrib><creatorcontrib>Sipos, Eva</creatorcontrib><creatorcontrib>Grochowski, Przemyslaw</creatorcontrib><creatorcontrib>Grosser, Bianca</creatorcontrib><creatorcontrib>Sommer, 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Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reitsam, Nic G</au><au>Märkl, Bruno</au><au>Dintner, Sebastian</au><au>Sipos, Eva</au><au>Grochowski, Przemyslaw</au><au>Grosser, Bianca</au><au>Sommer, Florian</au><au>Eser, Stefan</au><au>Nerlinger, Pia</au><au>Jordan, Frank</au><au>Rank, Andreas</au><au>Löhr, Phillip</au><au>Waidhauser, Johanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations in Natural Killer Cells in Colorectal Cancer Patients with Stroma AReactive Invasion Front Areas (SARIFA)</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2023-02-03</date><risdate>2023</risdate><volume>15</volume><issue>3</issue><spage>994</spage><pages>994-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Recently, our group introduced Stroma AReactive Invasion Front Areas (SARIFA) as an independent prognostic predictor for a poorer outcome in colon cancer patients, which is probably based on immunologic alterations combined with a direct tumor-adipocyte interaction: the two together reflecting a distinct tumor biology. Considering it is already known that peripheral immune cells are altered in colorectal cancer (CRC) patients, this study aims to investigate the changes in lymphocyte subsets in SARIFA-positive cases and correlate these changes with the local immune response.
Flow cytometry was performed to analyze B, T, and natural killer (NK) cells in the peripheral blood (PB) of 45 CRC patients. Consecutively, lymphocytes in PB, tumor-infiltrating lymphocytes (TILs), and CD56+ and CD57+ lymphocytes at the invasion front and the tumor center were compared between patients with SARIFA-positive and SARIFA-negative CRCs.
Whereas no differences could be observed regarding most PB lymphocyte populations as well as TILs, NK cells were dramatically reduced in the PB of SARIFA-positive cases. Moreover, CD56 and CD57 immunohistochemistry suggested SARIFA-status-dependent changes regarding NK cells and NK-like lymphocytes in the tumor microenvironment.
This study proves that our newly introduced biomarker, SARIFA, comes along with distinct immunologic alterations, especially regarding NK cells.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36765951</pmid><doi>10.3390/cancers15030994</doi><orcidid>https://orcid.org/0000-0003-3242-3027</orcidid><orcidid>https://orcid.org/0000-0003-4939-279X</orcidid><orcidid>https://orcid.org/0000-0002-5636-0043</orcidid><orcidid>https://orcid.org/0000-0002-0070-3158</orcidid><orcidid>https://orcid.org/0000-0002-7704-850X</orcidid><orcidid>https://orcid.org/0000-0003-2776-1590</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Adipocytes Automation Biological markers Biomarkers Blood & organ donations Carcinoma Care and treatment CD56 antigen CD57 antigen Colon cancer Colorectal cancer Colorectal carcinoma Flow cytometry Health aspects Immune response Immunohistochemistry Immunotherapy Inflammation Killer cells Lymphocytes Medical prognosis Metabolism Monoclonal antibodies Morphology Natural killer cells Patients Peripheral blood Stroma Surgery Tumor microenvironment Tumor-infiltrating lymphocytes Tumors |
| title | Alterations in Natural Killer Cells in Colorectal Cancer Patients with Stroma AReactive Invasion Front Areas (SARIFA) |
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