The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo

Lipid nanoparticles (LNPs) have delivered RNA to hepatocytes in patients, underscoring the potential impact of nonliver delivery. Scientists can shift LNP tropism to the lung by adding cationic helper lipids; however, the biological response to these LNPs remains understudied. To evaluate the hypoth...

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Veröffentlicht in:	Nano letters 2023-02, Vol.23 (3), p.993-1002
Hauptverfasser:	Radmand, Afsane, Lokugamage, Melissa P., Kim, Hyejin, Dobrowolski, Curtis, Zenhausern, Ryan, Loughrey, David, Huayamares, Sebastian G., Hatit, Marine Z. C., Ni, Huanzhen, Del Cid, Ada, Da Silva Sanchez, Alejandro J., Paunovska, Kalina, Schrader Echeverri, Elisa, Shajii, Aram, Peck, Hannah, Santangelo, Philip J., Dahlman, James E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Hepatocytes - metabolism Humans Letter Lipids Liposomes - metabolism Nanoparticles RNA, Messenger - genetics RNA, Small Interfering
Online-Zugang:	Volltext
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