Investigation of image-based lesion and kidney dosimetry protocols for 177Lu-PSMA-I&T therapy with and without a late SPECT/CT acquisition

Background 177 Lu-PSMA therapy has been successfully used to prolong the survival of patients with metastatic castration-resistant prostate cancer. Patient-specific dosimetry based on serial quantitative SPECT/CT imaging can support the understanding of dose–effect relationships. However, multiple S...

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Veröffentlicht in:	EJNMMI physics 2023-02, Vol.10 (1), p.11-11, Article 11
Hauptverfasser:	Resch, Sandra, Takayama Fouladgar, Sarah, Zacherl, Mathias, Sheikh, Gabriel T., Liubchenko, Grigory, Rumiantcev, Mikhail, Unterrainer, Lena M., Wenter, Vera, Bartenstein, Peter, Ziegler, Sibylle I., Ilhan, Harun, Beyer, Leonie, Böning, Guido, Delker, Astrid
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied and Technical Physics Biological effects Coefficient of variation Computational Mathematics and Numerical Analysis Computed tomography Deviation Dosimeters Dosimetry Engineering Goodness of fit Image segmentation Imaging Imaging and dosimetry for radionuclide based therapy Inspection Investigations Kidneys Lesions Lutetium isotopes Mathematical models Medicine Medicine & Public Health Nuclear Medicine Optimization Original Research Outliers (statistics) Parameters Radiology Sampling Schedules Therapy
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