Validation of the EQ-5D-5L and psychosocial bolt-ons in a large cohort of people living with multiple sclerosis in Australia
Background Multiple sclerosis (MS) is an inflammatory, neurodegenerative disease of the central nervous system which results in disability over time and reduced quality of life. To increase the sensitivity of the EQ-5D-5L for psychosocial health, four bolt-on items from the AQoL-8D were used to crea...
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| Veröffentlicht in: | Quality of life research 2023-02, Vol.32 (2), p.553-568 |
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| creator | Campbell, Julie A. Ahmad, Hasnat Chen, Gang van der Mei, Ingrid Taylor, Bruce V. Claflin, Suzi Henson, Glen J. Simpson-Yap, Steve Laslett, Laura L. Hawkes, Kirsty Hurst, Carol Waugh, Hilary Palmer, Andrew J. |
| description | Background
Multiple sclerosis (MS) is an inflammatory, neurodegenerative disease of the central nervous system which results in disability over time and reduced quality of life. To increase the sensitivity of the EQ-5D-5L for psychosocial health, four bolt-on items from the AQoL-8D were used to create the nine-item EQ-5D-5L-Psychosocial. We aimed to externally validate the EQ-5D-5L-Psychosocial in a large cohort of people with MS (pwMS) and explore the discriminatory power of the new instrument with EQ-5D-5L/AQoL-8D.
Methods
A large representative sample from the Australian MS Longitudinal Study completed the AQoL-8D and EQ-5D-5L (including EQ VAS) and both instruments health state utilities (HSUs) were scored using Australian tariffs. Sociodemographic/clinical data were also collected. External validity of EQ-5D-5L-Psychosocial scoring algorithm was assessed with mean absolute errors (MAE) and Spearman’s correlation coefficient. Discriminatory sensitivity was assessed with an examination of ceiling/floor effects, and disability severity classifications.
Results
Among 1683 participants (mean age: 58.6 years; 80% female), over half (55%) had moderate or severe disability. MAE (0.063) and the distribution of the prediction error were similar to the original development study. Mean (± standard deviation) HSUs were EQ-5D-5L: 0.58 ± 0.32, EQ-5D-5L-Psychosocial 0.62 ± 0.29, and AQoL-8D: 0.63 ± 0.20.
N
= 157 (10%) scored perfect health (i.e. HSU = 1.0) on the EQ-5D-5L, but reported a mean HSU of 0.90 on the alternative instruments. The Sleep bolt-on dimension was particularly important for pwMS.
Conclusions
The EQ-5D-5L-Psychosocial is more sensitive than the EQ-5D-5L in pwMS whose HSUs approach those reflecting full health. When respondent burden is taken into account, the EQ-5D-5L-Psychosocial is preferential to the AQoL-8D. We suggest a larger confirmatory study comparing all prevalent multi-attribute utility instruments for pwMS. |
| doi_str_mv | 10.1007/s11136-022-03214-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9911481</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2774708170</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-e78c3ebeea2c6ec023f747a6309ea01815b269ef43a182cafa14dcb319fd82693</originalsourceid><addsrcrecordid>eNp9kUuLFDEUhYMoTjv6B1xIwI2baF5dqdoIwzijQoMI6jakUre6MqSTMkmNNPjjJz09jo-Fq0Dud859HISeM_qaUareZMaYaAjlnFDBmST7B2jF1koQ3sjuIVrRruGkE1KcoCc5X1FK247yx-hENFQ0grEV-vnNeDeY4mLAccRlAnzxmazfkfUGmzDgOe_tFHO0znjcR19IDBm7gA32Jm0B2zjFVA7aGeLsAXt37cIW_3BlwrvFF3f4zNZDitndSs-WXFJta56iR6PxGZ7dvafo6-XFl_MPZPPp_cfzsw2xUslCQLVWQA9guG3AUi5GJZVpBO3AUNaydc-bDkYpDGu5NaNhcrC9YN04tLUiTtHbo--89DsYLIRDfz0ntzNpr6Nx-u9KcJPexmvddYzJllWDV3cGKX5fIBe9c9mC9yZAXLLmiqpWSUlFRV_-g17FJYW6XqXq2LRlilaKHylbr5ITjPfDMKoP4epjuLqGq2_D1fsqevHnGveSX2lWQByBXEthC-l37__Y3gAFU7G-</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2774708170</pqid></control><display><type>article</type><title>Validation of the EQ-5D-5L and psychosocial bolt-ons in a large cohort of people living with multiple sclerosis in Australia</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Campbell, Julie A. ; Ahmad, Hasnat ; Chen, Gang ; van der Mei, Ingrid ; Taylor, Bruce V. ; Claflin, Suzi ; Henson, Glen J. ; Simpson-Yap, Steve ; Laslett, Laura L. ; Hawkes, Kirsty ; Hurst, Carol ; Waugh, Hilary ; Palmer, Andrew J.</creator><creatorcontrib>Campbell, Julie A. ; Ahmad, Hasnat ; Chen, Gang ; van der Mei, Ingrid ; Taylor, Bruce V. ; Claflin, Suzi ; Henson, Glen J. ; Simpson-Yap, Steve ; Laslett, Laura L. ; Hawkes, Kirsty ; Hurst, Carol ; Waugh, Hilary ; Palmer, Andrew J.</creatorcontrib><description>Background
Multiple sclerosis (MS) is an inflammatory, neurodegenerative disease of the central nervous system which results in disability over time and reduced quality of life. To increase the sensitivity of the EQ-5D-5L for psychosocial health, four bolt-on items from the AQoL-8D were used to create the nine-item EQ-5D-5L-Psychosocial. We aimed to externally validate the EQ-5D-5L-Psychosocial in a large cohort of people with MS (pwMS) and explore the discriminatory power of the new instrument with EQ-5D-5L/AQoL-8D.
Methods
A large representative sample from the Australian MS Longitudinal Study completed the AQoL-8D and EQ-5D-5L (including EQ VAS) and both instruments health state utilities (HSUs) were scored using Australian tariffs. Sociodemographic/clinical data were also collected. External validity of EQ-5D-5L-Psychosocial scoring algorithm was assessed with mean absolute errors (MAE) and Spearman’s correlation coefficient. Discriminatory sensitivity was assessed with an examination of ceiling/floor effects, and disability severity classifications.
Results
Among 1683 participants (mean age: 58.6 years; 80% female), over half (55%) had moderate or severe disability. MAE (0.063) and the distribution of the prediction error were similar to the original development study. Mean (± standard deviation) HSUs were EQ-5D-5L: 0.58 ± 0.32, EQ-5D-5L-Psychosocial 0.62 ± 0.29, and AQoL-8D: 0.63 ± 0.20.
N
= 157 (10%) scored perfect health (i.e. HSU = 1.0) on the EQ-5D-5L, but reported a mean HSU of 0.90 on the alternative instruments. The Sleep bolt-on dimension was particularly important for pwMS.
Conclusions
The EQ-5D-5L-Psychosocial is more sensitive than the EQ-5D-5L in pwMS whose HSUs approach those reflecting full health. When respondent burden is taken into account, the EQ-5D-5L-Psychosocial is preferential to the AQoL-8D. We suggest a larger confirmatory study comparing all prevalent multi-attribute utility instruments for pwMS.</description><identifier>ISSN: 0962-9343</identifier><identifier>EISSN: 1573-2649</identifier><identifier>DOI: 10.1007/s11136-022-03214-y</identifier><identifier>PMID: 36036311</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Australia ; Female ; Humans ; Longitudinal Studies ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multiple Sclerosis ; Neurodegenerative Diseases ; Psychometrics - methods ; Public Health ; Quality of Life - psychology ; Quality of Life Research ; Sociology ; Surveys and Questionnaires</subject><ispartof>Quality of life research, 2023-02, Vol.32 (2), p.553-568</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-e78c3ebeea2c6ec023f747a6309ea01815b269ef43a182cafa14dcb319fd82693</citedby><cites>FETCH-LOGICAL-c474t-e78c3ebeea2c6ec023f747a6309ea01815b269ef43a182cafa14dcb319fd82693</cites><orcidid>0000-0001-6521-3056 ; 0000-0001-9009-7472 ; 0000-0002-8385-5965 ; 0000-0002-4336-0095 ; 0000-0002-1237-5710 ; 0000-0003-2807-0070 ; 0000-0002-1820-6758</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11136-022-03214-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11136-022-03214-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36036311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Campbell, Julie A.</creatorcontrib><creatorcontrib>Ahmad, Hasnat</creatorcontrib><creatorcontrib>Chen, Gang</creatorcontrib><creatorcontrib>van der Mei, Ingrid</creatorcontrib><creatorcontrib>Taylor, Bruce V.</creatorcontrib><creatorcontrib>Claflin, Suzi</creatorcontrib><creatorcontrib>Henson, Glen J.</creatorcontrib><creatorcontrib>Simpson-Yap, Steve</creatorcontrib><creatorcontrib>Laslett, Laura L.</creatorcontrib><creatorcontrib>Hawkes, Kirsty</creatorcontrib><creatorcontrib>Hurst, Carol</creatorcontrib><creatorcontrib>Waugh, Hilary</creatorcontrib><creatorcontrib>Palmer, Andrew J.</creatorcontrib><title>Validation of the EQ-5D-5L and psychosocial bolt-ons in a large cohort of people living with multiple sclerosis in Australia</title><title>Quality of life research</title><addtitle>Qual Life Res</addtitle><addtitle>Qual Life Res</addtitle><description>Background
Multiple sclerosis (MS) is an inflammatory, neurodegenerative disease of the central nervous system which results in disability over time and reduced quality of life. To increase the sensitivity of the EQ-5D-5L for psychosocial health, four bolt-on items from the AQoL-8D were used to create the nine-item EQ-5D-5L-Psychosocial. We aimed to externally validate the EQ-5D-5L-Psychosocial in a large cohort of people with MS (pwMS) and explore the discriminatory power of the new instrument with EQ-5D-5L/AQoL-8D.
Methods
A large representative sample from the Australian MS Longitudinal Study completed the AQoL-8D and EQ-5D-5L (including EQ VAS) and both instruments health state utilities (HSUs) were scored using Australian tariffs. Sociodemographic/clinical data were also collected. External validity of EQ-5D-5L-Psychosocial scoring algorithm was assessed with mean absolute errors (MAE) and Spearman’s correlation coefficient. Discriminatory sensitivity was assessed with an examination of ceiling/floor effects, and disability severity classifications.
Results
Among 1683 participants (mean age: 58.6 years; 80% female), over half (55%) had moderate or severe disability. MAE (0.063) and the distribution of the prediction error were similar to the original development study. Mean (± standard deviation) HSUs were EQ-5D-5L: 0.58 ± 0.32, EQ-5D-5L-Psychosocial 0.62 ± 0.29, and AQoL-8D: 0.63 ± 0.20.
N
= 157 (10%) scored perfect health (i.e. HSU = 1.0) on the EQ-5D-5L, but reported a mean HSU of 0.90 on the alternative instruments. The Sleep bolt-on dimension was particularly important for pwMS.
Conclusions
The EQ-5D-5L-Psychosocial is more sensitive than the EQ-5D-5L in pwMS whose HSUs approach those reflecting full health. When respondent burden is taken into account, the EQ-5D-5L-Psychosocial is preferential to the AQoL-8D. We suggest a larger confirmatory study comparing all prevalent multi-attribute utility instruments for pwMS.</description><subject>Australia</subject><subject>Female</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multiple Sclerosis</subject><subject>Neurodegenerative Diseases</subject><subject>Psychometrics - methods</subject><subject>Public Health</subject><subject>Quality of Life - psychology</subject><subject>Quality of Life Research</subject><subject>Sociology</subject><subject>Surveys and Questionnaires</subject><issn>0962-9343</issn><issn>1573-2649</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUuLFDEUhYMoTjv6B1xIwI2baF5dqdoIwzijQoMI6jakUre6MqSTMkmNNPjjJz09jo-Fq0Dud859HISeM_qaUareZMaYaAjlnFDBmST7B2jF1koQ3sjuIVrRruGkE1KcoCc5X1FK247yx-hENFQ0grEV-vnNeDeY4mLAccRlAnzxmazfkfUGmzDgOe_tFHO0znjcR19IDBm7gA32Jm0B2zjFVA7aGeLsAXt37cIW_3BlwrvFF3f4zNZDitndSs-WXFJta56iR6PxGZ7dvafo6-XFl_MPZPPp_cfzsw2xUslCQLVWQA9guG3AUi5GJZVpBO3AUNaydc-bDkYpDGu5NaNhcrC9YN04tLUiTtHbo--89DsYLIRDfz0ntzNpr6Nx-u9KcJPexmvddYzJllWDV3cGKX5fIBe9c9mC9yZAXLLmiqpWSUlFRV_-g17FJYW6XqXq2LRlilaKHylbr5ITjPfDMKoP4epjuLqGq2_D1fsqevHnGveSX2lWQByBXEthC-l37__Y3gAFU7G-</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Campbell, Julie A.</creator><creator>Ahmad, Hasnat</creator><creator>Chen, Gang</creator><creator>van der Mei, Ingrid</creator><creator>Taylor, Bruce V.</creator><creator>Claflin, Suzi</creator><creator>Henson, Glen J.</creator><creator>Simpson-Yap, Steve</creator><creator>Laslett, Laura L.</creator><creator>Hawkes, Kirsty</creator><creator>Hurst, Carol</creator><creator>Waugh, Hilary</creator><creator>Palmer, Andrew J.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>KB0</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6521-3056</orcidid><orcidid>https://orcid.org/0000-0001-9009-7472</orcidid><orcidid>https://orcid.org/0000-0002-8385-5965</orcidid><orcidid>https://orcid.org/0000-0002-4336-0095</orcidid><orcidid>https://orcid.org/0000-0002-1237-5710</orcidid><orcidid>https://orcid.org/0000-0003-2807-0070</orcidid><orcidid>https://orcid.org/0000-0002-1820-6758</orcidid></search><sort><creationdate>20230201</creationdate><title>Validation of the EQ-5D-5L and psychosocial bolt-ons in a large cohort of people living with multiple sclerosis in Australia</title><author>Campbell, Julie A. ; Ahmad, Hasnat ; Chen, Gang ; van der Mei, Ingrid ; Taylor, Bruce V. ; Claflin, Suzi ; Henson, Glen J. ; Simpson-Yap, Steve ; Laslett, Laura L. ; Hawkes, Kirsty ; Hurst, Carol ; Waugh, Hilary ; Palmer, Andrew J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-e78c3ebeea2c6ec023f747a6309ea01815b269ef43a182cafa14dcb319fd82693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Australia</topic><topic>Female</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multiple Sclerosis</topic><topic>Neurodegenerative Diseases</topic><topic>Psychometrics - methods</topic><topic>Public Health</topic><topic>Quality of Life - psychology</topic><topic>Quality of Life Research</topic><topic>Sociology</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campbell, Julie A.</creatorcontrib><creatorcontrib>Ahmad, Hasnat</creatorcontrib><creatorcontrib>Chen, Gang</creatorcontrib><creatorcontrib>van der Mei, Ingrid</creatorcontrib><creatorcontrib>Taylor, Bruce V.</creatorcontrib><creatorcontrib>Claflin, Suzi</creatorcontrib><creatorcontrib>Henson, Glen J.</creatorcontrib><creatorcontrib>Simpson-Yap, Steve</creatorcontrib><creatorcontrib>Laslett, Laura L.</creatorcontrib><creatorcontrib>Hawkes, Kirsty</creatorcontrib><creatorcontrib>Hurst, Carol</creatorcontrib><creatorcontrib>Waugh, Hilary</creatorcontrib><creatorcontrib>Palmer, Andrew J.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Access via ABI/INFORM (ProQuest)</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Quality of life research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campbell, Julie A.</au><au>Ahmad, Hasnat</au><au>Chen, Gang</au><au>van der Mei, Ingrid</au><au>Taylor, Bruce V.</au><au>Claflin, Suzi</au><au>Henson, Glen J.</au><au>Simpson-Yap, Steve</au><au>Laslett, Laura L.</au><au>Hawkes, Kirsty</au><au>Hurst, Carol</au><au>Waugh, Hilary</au><au>Palmer, Andrew J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation of the EQ-5D-5L and psychosocial bolt-ons in a large cohort of people living with multiple sclerosis in Australia</atitle><jtitle>Quality of life research</jtitle><stitle>Qual Life Res</stitle><addtitle>Qual Life Res</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>32</volume><issue>2</issue><spage>553</spage><epage>568</epage><pages>553-568</pages><issn>0962-9343</issn><eissn>1573-2649</eissn><abstract>Background
Multiple sclerosis (MS) is an inflammatory, neurodegenerative disease of the central nervous system which results in disability over time and reduced quality of life. To increase the sensitivity of the EQ-5D-5L for psychosocial health, four bolt-on items from the AQoL-8D were used to create the nine-item EQ-5D-5L-Psychosocial. We aimed to externally validate the EQ-5D-5L-Psychosocial in a large cohort of people with MS (pwMS) and explore the discriminatory power of the new instrument with EQ-5D-5L/AQoL-8D.
Methods
A large representative sample from the Australian MS Longitudinal Study completed the AQoL-8D and EQ-5D-5L (including EQ VAS) and both instruments health state utilities (HSUs) were scored using Australian tariffs. Sociodemographic/clinical data were also collected. External validity of EQ-5D-5L-Psychosocial scoring algorithm was assessed with mean absolute errors (MAE) and Spearman’s correlation coefficient. Discriminatory sensitivity was assessed with an examination of ceiling/floor effects, and disability severity classifications.
Results
Among 1683 participants (mean age: 58.6 years; 80% female), over half (55%) had moderate or severe disability. MAE (0.063) and the distribution of the prediction error were similar to the original development study. Mean (± standard deviation) HSUs were EQ-5D-5L: 0.58 ± 0.32, EQ-5D-5L-Psychosocial 0.62 ± 0.29, and AQoL-8D: 0.63 ± 0.20.
N
= 157 (10%) scored perfect health (i.e. HSU = 1.0) on the EQ-5D-5L, but reported a mean HSU of 0.90 on the alternative instruments. The Sleep bolt-on dimension was particularly important for pwMS.
Conclusions
The EQ-5D-5L-Psychosocial is more sensitive than the EQ-5D-5L in pwMS whose HSUs approach those reflecting full health. When respondent burden is taken into account, the EQ-5D-5L-Psychosocial is preferential to the AQoL-8D. We suggest a larger confirmatory study comparing all prevalent multi-attribute utility instruments for pwMS.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36036311</pmid><doi>10.1007/s11136-022-03214-y</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0001-6521-3056</orcidid><orcidid>https://orcid.org/0000-0001-9009-7472</orcidid><orcidid>https://orcid.org/0000-0002-8385-5965</orcidid><orcidid>https://orcid.org/0000-0002-4336-0095</orcidid><orcidid>https://orcid.org/0000-0002-1237-5710</orcidid><orcidid>https://orcid.org/0000-0003-2807-0070</orcidid><orcidid>https://orcid.org/0000-0002-1820-6758</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Quality of life research, 2023-02, Vol.32 (2), p.553-568 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9911481 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Australia Female Humans Longitudinal Studies Male Medicine Medicine & Public Health Middle Aged Multiple Sclerosis Neurodegenerative Diseases Psychometrics - methods Public Health Quality of Life - psychology Quality of Life Research Sociology Surveys and Questionnaires |
| title | Validation of the EQ-5D-5L and psychosocial bolt-ons in a large cohort of people living with multiple sclerosis in Australia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T17%3A18%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Validation%20of%20the%20EQ-5D-5L%20and%20psychosocial%20bolt-ons%20in%20a%20large%20cohort%20of%20people%20living%20with%20multiple%20sclerosis%20in%20Australia&rft.jtitle=Quality%20of%20life%20research&rft.au=Campbell,%20Julie%20A.&rft.date=2023-02-01&rft.volume=32&rft.issue=2&rft.spage=553&rft.epage=568&rft.pages=553-568&rft.issn=0962-9343&rft.eissn=1573-2649&rft_id=info:doi/10.1007/s11136-022-03214-y&rft_dat=%3Cproquest_pubme%3E2774708170%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2774708170&rft_id=info:pmid/36036311&rfr_iscdi=true |