Mining metatranscriptomes reveals a vast world of viroid-like circular RNAs

Viroids and viroid-like covalently closed circular (ccc) RNAs are minimal replicators that typically encode no proteins and hijack cellular enzymes for replication. The extent and diversity of viroid-like agents are poorly understood. We developed a computational pipeline to identify viroid-like ccc...

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Veröffentlicht in:	Cell 2023-02, Vol.186 (3), p.646-661.e4
Hauptverfasser:	Lee, Benjamin D., Neri, Uri, Roux, Simon, Wolf, Yuri I., Camargo, Antonio Pedro, Krupovic, Mart, Simmonds, Peter, Kyrpides, Nikos, Gophna, Uri, Dolja, Valerian V., Koonin, Eugene V.
Format:	Artikel
Sprache:	eng
Schlagworte:	BASIC BIOLOGICAL SCIENCES Ecosystem Life Sciences Plant Diseases RNA, Catalytic - genetics RNA, Circular - metabolism RNA, Viral - genetics RNA, Viral - metabolism Viroids - genetics Viroids - metabolism
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