HIV silencing and cell survival signatures in infected T cell reservoirs

Rare CD4 T cells that contain HIV under antiretroviral therapy represent an important barrier to HIV cure 1 – 3 , but the infeasibility of isolating and characterizing these cells in their natural state has led to uncertainty about whether they possess distinctive attributes that HIV cure-directed t...

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Veröffentlicht in:	Nature (London) 2023-02, Vol.614 (7947), p.318-325
Hauptverfasser:	Clark, Iain C., Mudvari, Prakriti, Thaploo, Shravan, Smith, Samuel, Abu-Laban, Mohammad, Hamouda, Mehdi, Theberge, Marc, Shah, Sakshi, Ko, Sung Hee, Pérez, Liliana, Bunis, Daniel G., Lee, James S., Kilam, Divya, Zakaria, Saami, Choi, Sally, Darko, Samuel, Henry, Amy R., Wheeler, Michael A., Hoh, Rebecca, Butrus, Salwan, Deeks, Steven G., Quintana, Francisco J., Douek, Daniel C., Abate, Adam R., Boritz, Eli A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/62 38/39 38/91 631/250/255/1901 631/326/421 692/699/255/1901 Anti-Retroviral Agents - pharmacology Anti-Retroviral Agents - therapeutic use Antiretroviral agents Antiretroviral therapy CD4 antigen CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology Cell growth Cell proliferation Cell Proliferation - drug effects Cell survival Cell Survival - drug effects Deoxyribonucleic acid DNA DNA, Viral - isolation & purification Drug therapy Gene expression Gene Expression Regulation, Viral - drug effects Genes Genetic engineering HIV HIV Infections - drug therapy HIV Infections - genetics HIV Infections - immunology HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics HIV-1 - isolation & purification HIV-1 - pathogenicity Human immunodeficiency virus Humanities and Social Sciences Humans Immunologic Memory Immunological memory Lymphocytes Lymphocytes T Memory cells Microfluidics multidisciplinary Necroptosis Necroptosis - drug effects RNA processing Science Science (multidisciplinary) Signal transduction Signal Transduction - drug effects Signaling Survival Therapy Transcriptome - drug effects Transcriptomes Transcriptomics Virus Latency - drug effects Viruses
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