Exosomes from Adipose-Derived Stem Cells Alleviate Dexamethasone-Induced Bone Loss by Regulating the Nrf2/HO-1 Axis

The widespread use of therapeutic glucocorticoids has increased the incidences of glucocorticoid-induced osteoporosis (GIOP). Oxidative stress and mitochondrial dysfunction are major causes of GIOP; therefore, alleviation of excess oxidative stress in osteoblasts is a potential therapeutic strategy...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2023, Vol.2023, p.3602962-20
Hauptverfasser:	Yao, Xue-wei, Liu, Zhi-yi, Ma, Neng-feng, Jiang, Wen-kai, Zhou, Zhi, Chen, Bing, Guan, Wen-gang, Yan, Jun-jie, Yang, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Dexamethasone - adverse effects Exosomes - metabolism Flow cytometry Glucocorticoids - adverse effects Heme Oxygenase-1 Homeostasis Manufacturers Mesenchymal Stem Cells - metabolism Mice Microscopy NF-E2-Related Factor 2 - metabolism Osteoporosis Osteoporosis - chemically induced Osteoporosis - metabolism Oxidative stress Rats Stem cells Steroids
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