Maternal and prenatal factors and age at thelarche in the LEGACY Girls Study cohort: implications for breast cancer risk
Earlier onset of breast development (thelarche) is associated with increased breast cancer risk. Identifying modifiable factors associated with earlier thelarche may provide an opportunity for breast cancer risk reduction starting early in life, which could especially benefit girls with a greater ab...
Gespeichert in:
| Veröffentlicht in: | International journal of epidemiology 2023-02, Vol.52 (1), p.272-283 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 283 |
|---|---|
| container_issue | 1 |
| container_start_page | 272 |
| container_title | International journal of epidemiology |
| container_volume | 52 |
| creator | Goldberg, Mandy McDonald, Jasmine A Houghton, Lauren C Andrulis, Irene L Knight, Julia A Bradbury, Angela R Schwartz, Lisa A Buys, Saundra S Frost, Caren J Daly, Mary B John, Esther M Keegan, Theresa H M Chung, Wendy K Wei, Ying Terry, Mary Beth |
| description | Earlier onset of breast development (thelarche) is associated with increased breast cancer risk. Identifying modifiable factors associated with earlier thelarche may provide an opportunity for breast cancer risk reduction starting early in life, which could especially benefit girls with a greater absolute risk of breast cancer due to family history.
We assessed associations of maternal pre-pregnancy body mass index (BMI), physical activity during pregnancy, gestational weight gain and daughters' weight and length at birth with age at thelarche using longitudinal Weibull models in 1031 girls in the Lessons in Epidemiology and Genetics of Adult Cancer from Youth (LEGACY) Girls Study-a prospective cohort of girls, half of whom have a breast cancer family history (BCFH).
Girls whose mothers had a pre-pregnancy BMI of ≥25 and gained ≥30 lbs were 57% more likely to experience earlier thelarche than girls whose mothers had a pre-pregnancy BMI of |
| doi_str_mv | 10.1093/ije/dyac108 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9908055</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2669501771</sourcerecordid><originalsourceid>FETCH-LOGICAL-c381t-11eb9b6468a4c6e3b3748f1f5117cba1987016f1f75d0bab2e2e99a9397368833</originalsourceid><addsrcrecordid>eNpVUcFuEzEQtRAVDYUTd-QjElrqidfedQ9IVVRCpSAOLQdO1qx3tnHZ2KntIPL3bGlaldPovXl6M3qPsXcgPoEw8tTf0mm_RweifcFmUOu6krpVL9lMSCEq1TRwzF7nfCsE1HVtXrFjqTRIAWrG_nzDQingyDH0fJsoYJnAgK7ElP-ReEMcCy9rGjG5NXEf7gFfXSzPFz_50qcx86uy6_fcxXVM5Yz7zXb0DouPIfMhJt4lwly4w-Ao8eTzrzfsaMAx09vDPGE_vlxcL75Wq-_Ly8X5qnKyhVIBUGc6XesWa6dJdrKp2wEGBdC4DsG0jQA9EY3qRYfdnOZkDBppmimEVsoT9vnBd7vrNtQ7CiXhaLfJbzDtbURv_98Ev7Y38bc1RrRCqcngw8Egxbsd5WI3PjsaRwwUd9nOtTZKwJTyJP34IHUp5pxoeDoDwt53Zaeu7KGrSf3--WdP2sdy5F_cSJJQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2669501771</pqid></control><display><type>article</type><title>Maternal and prenatal factors and age at thelarche in the LEGACY Girls Study cohort: implications for breast cancer risk</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Goldberg, Mandy ; McDonald, Jasmine A ; Houghton, Lauren C ; Andrulis, Irene L ; Knight, Julia A ; Bradbury, Angela R ; Schwartz, Lisa A ; Buys, Saundra S ; Frost, Caren J ; Daly, Mary B ; John, Esther M ; Keegan, Theresa H M ; Chung, Wendy K ; Wei, Ying ; Terry, Mary Beth</creator><creatorcontrib>Goldberg, Mandy ; McDonald, Jasmine A ; Houghton, Lauren C ; Andrulis, Irene L ; Knight, Julia A ; Bradbury, Angela R ; Schwartz, Lisa A ; Buys, Saundra S ; Frost, Caren J ; Daly, Mary B ; John, Esther M ; Keegan, Theresa H M ; Chung, Wendy K ; Wei, Ying ; Terry, Mary Beth</creatorcontrib><description>Earlier onset of breast development (thelarche) is associated with increased breast cancer risk. Identifying modifiable factors associated with earlier thelarche may provide an opportunity for breast cancer risk reduction starting early in life, which could especially benefit girls with a greater absolute risk of breast cancer due to family history.
We assessed associations of maternal pre-pregnancy body mass index (BMI), physical activity during pregnancy, gestational weight gain and daughters' weight and length at birth with age at thelarche using longitudinal Weibull models in 1031 girls in the Lessons in Epidemiology and Genetics of Adult Cancer from Youth (LEGACY) Girls Study-a prospective cohort of girls, half of whom have a breast cancer family history (BCFH).
Girls whose mothers had a pre-pregnancy BMI of ≥25 and gained ≥30 lbs were 57% more likely to experience earlier thelarche than girls whose mothers had a pre-pregnancy BMI of <25 and gained <30 lbs [hazard ratio (HR) = 1.57, 95% CI: 1.16, 2.12]. This association was not mediated by childhood BMI and was similar in girls with and without a BCFH (BCFH: HR = 1.41, 95% CI: 0.87, 2.27; No BCFH: HR = 1.62, 95% CI: 1.10, 2.40). Daughters of women who reported no recreational physical activity during pregnancy were more likely to experience earlier thelarche compared with daughters of physically active women. Birthweight and birth length were not associated with thelarche.
Earlier thelarche, a breast cancer risk factor, was associated with three potentially modifiable maternal risk factors-pre-pregnancy BMI, gestational weight gain and physical inactivity-in a cohort of girls enriched for BCFH.</description><identifier>ISSN: 0300-5771</identifier><identifier>EISSN: 1464-3685</identifier><identifier>DOI: 10.1093/ije/dyac108</identifier><identifier>PMID: 35613015</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adolescent ; Adult ; Body Mass Index ; Breast ; Breast Neoplasms - epidemiology ; Child ; Female ; Gestational Weight Gain ; Humans ; Infant, Newborn ; Miscellaneous ; Pregnancy ; Prospective Studies ; Risk</subject><ispartof>International journal of epidemiology, 2023-02, Vol.52 (1), p.272-283</ispartof><rights>The Author(s) 2022; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.</rights><rights>The Author(s) 2022; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-11eb9b6468a4c6e3b3748f1f5117cba1987016f1f75d0bab2e2e99a9397368833</citedby><cites>FETCH-LOGICAL-c381t-11eb9b6468a4c6e3b3748f1f5117cba1987016f1f75d0bab2e2e99a9397368833</cites><orcidid>0000-0002-6794-1206 ; 0000-0002-1432-1580 ; 0000-0002-4106-5033</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35613015$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goldberg, Mandy</creatorcontrib><creatorcontrib>McDonald, Jasmine A</creatorcontrib><creatorcontrib>Houghton, Lauren C</creatorcontrib><creatorcontrib>Andrulis, Irene L</creatorcontrib><creatorcontrib>Knight, Julia A</creatorcontrib><creatorcontrib>Bradbury, Angela R</creatorcontrib><creatorcontrib>Schwartz, Lisa A</creatorcontrib><creatorcontrib>Buys, Saundra S</creatorcontrib><creatorcontrib>Frost, Caren J</creatorcontrib><creatorcontrib>Daly, Mary B</creatorcontrib><creatorcontrib>John, Esther M</creatorcontrib><creatorcontrib>Keegan, Theresa H M</creatorcontrib><creatorcontrib>Chung, Wendy K</creatorcontrib><creatorcontrib>Wei, Ying</creatorcontrib><creatorcontrib>Terry, Mary Beth</creatorcontrib><title>Maternal and prenatal factors and age at thelarche in the LEGACY Girls Study cohort: implications for breast cancer risk</title><title>International journal of epidemiology</title><addtitle>Int J Epidemiol</addtitle><description>Earlier onset of breast development (thelarche) is associated with increased breast cancer risk. Identifying modifiable factors associated with earlier thelarche may provide an opportunity for breast cancer risk reduction starting early in life, which could especially benefit girls with a greater absolute risk of breast cancer due to family history.
We assessed associations of maternal pre-pregnancy body mass index (BMI), physical activity during pregnancy, gestational weight gain and daughters' weight and length at birth with age at thelarche using longitudinal Weibull models in 1031 girls in the Lessons in Epidemiology and Genetics of Adult Cancer from Youth (LEGACY) Girls Study-a prospective cohort of girls, half of whom have a breast cancer family history (BCFH).
Girls whose mothers had a pre-pregnancy BMI of ≥25 and gained ≥30 lbs were 57% more likely to experience earlier thelarche than girls whose mothers had a pre-pregnancy BMI of <25 and gained <30 lbs [hazard ratio (HR) = 1.57, 95% CI: 1.16, 2.12]. This association was not mediated by childhood BMI and was similar in girls with and without a BCFH (BCFH: HR = 1.41, 95% CI: 0.87, 2.27; No BCFH: HR = 1.62, 95% CI: 1.10, 2.40). Daughters of women who reported no recreational physical activity during pregnancy were more likely to experience earlier thelarche compared with daughters of physically active women. Birthweight and birth length were not associated with thelarche.
Earlier thelarche, a breast cancer risk factor, was associated with three potentially modifiable maternal risk factors-pre-pregnancy BMI, gestational weight gain and physical inactivity-in a cohort of girls enriched for BCFH.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Body Mass Index</subject><subject>Breast</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Child</subject><subject>Female</subject><subject>Gestational Weight Gain</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Miscellaneous</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Risk</subject><issn>0300-5771</issn><issn>1464-3685</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUcFuEzEQtRAVDYUTd-QjElrqidfedQ9IVVRCpSAOLQdO1qx3tnHZ2KntIPL3bGlaldPovXl6M3qPsXcgPoEw8tTf0mm_RweifcFmUOu6krpVL9lMSCEq1TRwzF7nfCsE1HVtXrFjqTRIAWrG_nzDQingyDH0fJsoYJnAgK7ElP-ReEMcCy9rGjG5NXEf7gFfXSzPFz_50qcx86uy6_fcxXVM5Yz7zXb0DouPIfMhJt4lwly4w-Ao8eTzrzfsaMAx09vDPGE_vlxcL75Wq-_Ly8X5qnKyhVIBUGc6XesWa6dJdrKp2wEGBdC4DsG0jQA9EY3qRYfdnOZkDBppmimEVsoT9vnBd7vrNtQ7CiXhaLfJbzDtbURv_98Ev7Y38bc1RrRCqcngw8Egxbsd5WI3PjsaRwwUd9nOtTZKwJTyJP34IHUp5pxoeDoDwt53Zaeu7KGrSf3--WdP2sdy5F_cSJJQ</recordid><startdate>20230208</startdate><enddate>20230208</enddate><creator>Goldberg, Mandy</creator><creator>McDonald, Jasmine A</creator><creator>Houghton, Lauren C</creator><creator>Andrulis, Irene L</creator><creator>Knight, Julia A</creator><creator>Bradbury, Angela R</creator><creator>Schwartz, Lisa A</creator><creator>Buys, Saundra S</creator><creator>Frost, Caren J</creator><creator>Daly, Mary B</creator><creator>John, Esther M</creator><creator>Keegan, Theresa H M</creator><creator>Chung, Wendy K</creator><creator>Wei, Ying</creator><creator>Terry, Mary Beth</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6794-1206</orcidid><orcidid>https://orcid.org/0000-0002-1432-1580</orcidid><orcidid>https://orcid.org/0000-0002-4106-5033</orcidid></search><sort><creationdate>20230208</creationdate><title>Maternal and prenatal factors and age at thelarche in the LEGACY Girls Study cohort: implications for breast cancer risk</title><author>Goldberg, Mandy ; McDonald, Jasmine A ; Houghton, Lauren C ; Andrulis, Irene L ; Knight, Julia A ; Bradbury, Angela R ; Schwartz, Lisa A ; Buys, Saundra S ; Frost, Caren J ; Daly, Mary B ; John, Esther M ; Keegan, Theresa H M ; Chung, Wendy K ; Wei, Ying ; Terry, Mary Beth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-11eb9b6468a4c6e3b3748f1f5117cba1987016f1f75d0bab2e2e99a9397368833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Body Mass Index</topic><topic>Breast</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Child</topic><topic>Female</topic><topic>Gestational Weight Gain</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Miscellaneous</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Risk</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goldberg, Mandy</creatorcontrib><creatorcontrib>McDonald, Jasmine A</creatorcontrib><creatorcontrib>Houghton, Lauren C</creatorcontrib><creatorcontrib>Andrulis, Irene L</creatorcontrib><creatorcontrib>Knight, Julia A</creatorcontrib><creatorcontrib>Bradbury, Angela R</creatorcontrib><creatorcontrib>Schwartz, Lisa A</creatorcontrib><creatorcontrib>Buys, Saundra S</creatorcontrib><creatorcontrib>Frost, Caren J</creatorcontrib><creatorcontrib>Daly, Mary B</creatorcontrib><creatorcontrib>John, Esther M</creatorcontrib><creatorcontrib>Keegan, Theresa H M</creatorcontrib><creatorcontrib>Chung, Wendy K</creatorcontrib><creatorcontrib>Wei, Ying</creatorcontrib><creatorcontrib>Terry, Mary Beth</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goldberg, Mandy</au><au>McDonald, Jasmine A</au><au>Houghton, Lauren C</au><au>Andrulis, Irene L</au><au>Knight, Julia A</au><au>Bradbury, Angela R</au><au>Schwartz, Lisa A</au><au>Buys, Saundra S</au><au>Frost, Caren J</au><au>Daly, Mary B</au><au>John, Esther M</au><au>Keegan, Theresa H M</au><au>Chung, Wendy K</au><au>Wei, Ying</au><au>Terry, Mary Beth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal and prenatal factors and age at thelarche in the LEGACY Girls Study cohort: implications for breast cancer risk</atitle><jtitle>International journal of epidemiology</jtitle><addtitle>Int J Epidemiol</addtitle><date>2023-02-08</date><risdate>2023</risdate><volume>52</volume><issue>1</issue><spage>272</spage><epage>283</epage><pages>272-283</pages><issn>0300-5771</issn><eissn>1464-3685</eissn><abstract>Earlier onset of breast development (thelarche) is associated with increased breast cancer risk. Identifying modifiable factors associated with earlier thelarche may provide an opportunity for breast cancer risk reduction starting early in life, which could especially benefit girls with a greater absolute risk of breast cancer due to family history.
We assessed associations of maternal pre-pregnancy body mass index (BMI), physical activity during pregnancy, gestational weight gain and daughters' weight and length at birth with age at thelarche using longitudinal Weibull models in 1031 girls in the Lessons in Epidemiology and Genetics of Adult Cancer from Youth (LEGACY) Girls Study-a prospective cohort of girls, half of whom have a breast cancer family history (BCFH).
Girls whose mothers had a pre-pregnancy BMI of ≥25 and gained ≥30 lbs were 57% more likely to experience earlier thelarche than girls whose mothers had a pre-pregnancy BMI of <25 and gained <30 lbs [hazard ratio (HR) = 1.57, 95% CI: 1.16, 2.12]. This association was not mediated by childhood BMI and was similar in girls with and without a BCFH (BCFH: HR = 1.41, 95% CI: 0.87, 2.27; No BCFH: HR = 1.62, 95% CI: 1.10, 2.40). Daughters of women who reported no recreational physical activity during pregnancy were more likely to experience earlier thelarche compared with daughters of physically active women. Birthweight and birth length were not associated with thelarche.
Earlier thelarche, a breast cancer risk factor, was associated with three potentially modifiable maternal risk factors-pre-pregnancy BMI, gestational weight gain and physical inactivity-in a cohort of girls enriched for BCFH.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>35613015</pmid><doi>10.1093/ije/dyac108</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6794-1206</orcidid><orcidid>https://orcid.org/0000-0002-1432-1580</orcidid><orcidid>https://orcid.org/0000-0002-4106-5033</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-5771 |
| ispartof | International journal of epidemiology, 2023-02, Vol.52 (1), p.272-283 |
| issn | 0300-5771 1464-3685 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9908055 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Body Mass Index Breast Breast Neoplasms - epidemiology Child Female Gestational Weight Gain Humans Infant, Newborn Miscellaneous Pregnancy Prospective Studies Risk |
| title | Maternal and prenatal factors and age at thelarche in the LEGACY Girls Study cohort: implications for breast cancer risk |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T11%3A00%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Maternal%20and%20prenatal%20factors%20and%20age%20at%20thelarche%20in%20the%20LEGACY%20Girls%20Study%20cohort:%20implications%20for%20breast%20cancer%20risk&rft.jtitle=International%20journal%20of%20epidemiology&rft.au=Goldberg,%20Mandy&rft.date=2023-02-08&rft.volume=52&rft.issue=1&rft.spage=272&rft.epage=283&rft.pages=272-283&rft.issn=0300-5771&rft.eissn=1464-3685&rft_id=info:doi/10.1093/ije/dyac108&rft_dat=%3Cproquest_pubme%3E2669501771%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2669501771&rft_id=info:pmid/35613015&rfr_iscdi=true |