Characterization and ex vivo evaluation of excised skin samples as substitutes for human dermal barrier in pharmaceutical and dermatological studies

Background Excised animal and human skins are frequently used in permeability testing in pharmaceutical research. Several factors exist that may have influence on the results. In the current study some of the skin parameters that may affect drug permeability were analysed for human, mouse, rat and p...

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Veröffentlicht in:	Skin research and technology 2022-09, Vol.28 (5), p.664-676
Hauptverfasser:	Kocsis, Dorottya, Klang, Victoria, Schweiger, Eva‐Maria, Varga‐Medveczky, Zsófia, Mihály, Anna, Pongor, Csaba, Révész, Zsolt, Somogyi, Zoltán, Erdő, Franciska
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging (natural) Animals Ceramide Ceramides - metabolism Chemical composition Cholesterol confocal Raman spectroscopy dermal barrier Epidermis Evaluation excised skins Freeze-thaw Freezing freezing/thawing Humans Hydration Keratin Keratins - metabolism Lipids Mechanical properties Mice Microscopy Moisture content Original Parameters Permeability Permittivity pH effects Pharmaceutical Preparations - metabolism Pharmaceuticals Pigskins Psoriasis Raman spectroscopy Rats Scanning electron microscopy Skin - metabolism Skin diseases Skin tests Swine tape stripping TEWL Thawing two‐photon microscopy Urea Urea - metabolism Water - metabolism Water content Water loss Water Loss, Insensible - physiology
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