Pharmacokinetic and Target Engagement Measures of ANX007, an Anti-C1q Antibody Fragment, Following Intravitreal Administration in Nonhuman Primates

C1q and the classical complement cascade are key regulators of synaptic pruning, and their aberrant activation has been implicated in neurodegenerative ophthalmic diseases including geographic atrophy and glaucoma. The antigen-binding fragment antibody ANX007 specifically recognizes globular head gr...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2023-02, Vol.64 (2), p.3-3
Hauptverfasser:	Grover, Anita, Sankaranarayanan, Sethu, Mathur, Vidhu, Suri, Poojan, Qiu, Haiyan, Andrews-Zwilling, Yaisa, Mease, Kirsten, Taylor, Lori K, Cahir-McFarland, Ellen, Keswani, Sanjay, Yednock, Ted
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Female Immunoglobulin Fab Fragments Macaca fascicularis Male Retina Retina - metabolism Tissue Distribution Vitreous Body - metabolism
Online-Zugang:	Volltext
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