Defining the Intravital Renal Disposition of Fluorescence-Quenched Exenatide

Despite the understanding that renal clearance is pivotal for driving the pharmacokinetics of numerous therapeutic proteins and peptides, the specific processes that occur following glomerular filtration remain poorly defined. For instance, sites of catabolism within the proximal tubule can occur at...

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Veröffentlicht in:	Molecular pharmaceutics 2023-02, Vol.20 (2), p.987-996
Hauptverfasser:	Bryniarski, Mark A., Sandoval, Ruben M., Ruszaj, Donna M., Fraser-McArthur, John, Yee, Benjamin M., Yacoub, Rabi, Chaves, Lee D., Campos-Bilderback, Silvia B., Molitoris, Bruce A., Morris, Marilyn E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Mellitus, Type 2 - metabolism Exenatide - metabolism Exenatide - pharmacokinetics Kidney - metabolism Kidney Tubules, Proximal - metabolism Peptides - metabolism Rats
Online-Zugang:	Volltext
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