Leisure-time physical activity is associated with reduced risks of breast cancer and triple negative breast cancer in Nigerian women
Leisure-time physical activity(LTPA) is associated with a reduced risk of breast cancer, but this has less been investigated by cancer subtypes in Africans living in Sub-Saharan Africa(SSA). We examined the associations between LTPA and breast cancer including its subtypes in Nigerian women and expl...
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| Veröffentlicht in: | Cancer epidemiology 2022-08, Vol.79, p.102195-102195, Article 102195 |
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| creator | Bigman, Galya Adebamowo, Sally N. Yawe, King-David Terna Yilkudi, Monday Olaomi, Oluwole Badejo, Olawale Famooto, Ayo Ezeome, Emmanuel Salu, Iliya Karniliyus Miner, Elijah Anosike, Ikechukwu Achusi, Benjamin Adebamowo, Clement |
| description | Leisure-time physical activity(LTPA) is associated with a reduced risk of breast cancer, but this has less been investigated by cancer subtypes in Africans living in Sub-Saharan Africa(SSA). We examined the associations between LTPA and breast cancer including its subtypes in Nigerian women and explored the effect modification of body size on such associations.
The sample included 508 newly diagnosed primary invasive breast cancer cases and 892 controls from the Nigerian Integrative Epidemiology of Breast Cancer(NIBBLE) Study. Immunohistochemical(IHC) analysis was available for 294 cases. Total metabolic equivalents(METs) per hour/week of LTPA were calculated and divided by quartiles(Q1 |
| doi_str_mv | 10.1016/j.canep.2022.102195 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9904209</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S187778212200100X</els_id><sourcerecordid>2678744520</sourcerecordid><originalsourceid>FETCH-LOGICAL-c487t-86842a92952672f51480a6829977f096b2d4b51ce9d28b6ec4531cb940f14e453</originalsourceid><addsrcrecordid>eNp9kUtv1DAUhSMEoqXwC5CQJTZsMtgeJ7YXIKGKR6VR2YDEznKcm5k7JHGwnalmzw_Hw5RR6aIrv757fO49RfGS0QWjrH67XTg7wrTglPN8w5muHhXnTElZSrX88fi05-yseBbjltK6Zqx6WpwtK8lkrdR58XsFGOcAZcIByLTZR3S2J9Yl3GHaE4zExugd2gQtucG0IQHa2eVDwPgzEt-RJoCNiWQ3DgKxY0tSwKkHMsLaZh24R-BIrnENAe1IbvwA4_PiSWf7CC9u14vi-6eP3y6_lKuvn68uP6xKJ5RMpaqV4FZzXfFa8q5iQlFbK661lB3VdcNb0VTMgW65ampwoloy12hBOyYgHy6K90fdaW4GaB2MKdjeTAEHG_bGWzT_v4y4MWu_M1pTwanOAm9uBYL_NUNMZsDooO9zEH6OJvtSUoiK04y-vodu_RzG3F6mVNajlB4cLY-UCz7GAN3JDKPmkLLZmr8pm0PK5phyrnp1t49Tzb9YM_DuCECe5g4hmOgQ8vBbDOCSaT0--MEfoWq7Qg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2689040005</pqid></control><display><type>article</type><title>Leisure-time physical activity is associated with reduced risks of breast cancer and triple negative breast cancer in Nigerian women</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>ProQuest Central UK/Ireland</source><creator>Bigman, Galya ; Adebamowo, Sally N. ; Yawe, King-David Terna ; Yilkudi, Monday ; Olaomi, Oluwole ; Badejo, Olawale ; Famooto, Ayo ; Ezeome, Emmanuel ; Salu, Iliya Karniliyus ; Miner, Elijah ; Anosike, Ikechukwu ; Achusi, Benjamin ; Adebamowo, Clement</creator><creatorcontrib>Bigman, Galya ; Adebamowo, Sally N. ; Yawe, King-David Terna ; Yilkudi, Monday ; Olaomi, Oluwole ; Badejo, Olawale ; Famooto, Ayo ; Ezeome, Emmanuel ; Salu, Iliya Karniliyus ; Miner, Elijah ; Anosike, Ikechukwu ; Achusi, Benjamin ; Adebamowo, Clement</creatorcontrib><description>Leisure-time physical activity(LTPA) is associated with a reduced risk of breast cancer, but this has less been investigated by cancer subtypes in Africans living in Sub-Saharan Africa(SSA). We examined the associations between LTPA and breast cancer including its subtypes in Nigerian women and explored the effect modification of body size on such associations.
The sample included 508 newly diagnosed primary invasive breast cancer cases and 892 controls from the Nigerian Integrative Epidemiology of Breast Cancer(NIBBLE) Study. Immunohistochemical(IHC) analysis was available for 294 cases. Total metabolic equivalents(METs) per hour/week of LTPA were calculated and divided by quartiles(Q1 <3.75, Q2:3.75–6.69, Q3:6.70–14.74, Q4:14.75 ≤). We applied logistic regressions to estimate the adjusted Odds Ratios(ORs) between LTPA and breast cancer and by its molecular subtypes and whether age-adjusted associations are modified by BMI.
The mean age(Mean±SD) of cases vs. controls(45.5 ± 11.1vs.40.1 ± 9.0) was higher, and the mean total METs hour/week was higher in controls vs. cases(11.9 ± 14.9vs.8.3 ± 11.1,p-value<0.001). Overall, 43.2%(N = 127/294) were classified as HRP, and 41.8%(N = 123/294) as TNBC. Women in the higher LTPA quartiles(Q3-Q4) vs. Q1 had lower odds of having breast cancer(ORQ4vs.Q1=0.51,95%CI:0.35–0.74) and TNBC(ORQ4vs.Q1=0.51, 95%CI:0.27–0.96), but not HRP(ORQ4vs.Q1=0.61,95%CI:0.34–1.09) after adjusting for age, age at first menarche, body size, breastfeeding, menopausal, parity, contraceptives, demographics, alcohol, smoking, and physical activity at home and work. Lastly, LTPA and its age-adjusted association with breast cancer was more pronounced in women with BMI< 30 vs. BMI 30 + .
LTPA may reduce the risk of breast cancer, especially TNBC, which is the more aggressive and prevalent molecular subtype of breast cancer in SSA.
•Breast cancer incidence in sub-Saharan Africa (SSA) is rising, and it is the most common cancer among Nigerian women.•Leisure-time physical activity (LTPA) is associated with a reduced risk of breast cancer and it varied by its subtypes.•LTPA and its age-adjusted association with breast cancer was more pronounced in non-obese vs. obese women.</description><identifier>ISSN: 1877-7821</identifier><identifier>EISSN: 1877-783X</identifier><identifier>DOI: 10.1016/j.canep.2022.102195</identifier><identifier>PMID: 35717688</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Age ; Biopsy ; Body mass index ; Body size ; Breast cancer ; Breast feeding ; Breastfeeding & lactation ; Cancer ; Contraceptives ; Demographics ; Epidemiology ; Exercise ; Female ; Growth factors ; Health risks ; Humans ; Insulin resistance ; Invasiveness ; Leisure ; Leisure Activities ; Leisure-time physical activity ; Menarche ; Menopause ; Motor Activity ; Nigeria ; Nigeria - epidemiology ; Nurses ; Physical activity ; Physical fitness ; Pregnancy ; Quartiles ; Questionnaires ; Risk management ; Socioeconomic factors ; Sub-Saharan Africa ; Teaching hospitals ; Triple Negative Breast Neoplasms - epidemiology ; Triple-negative ; Tumors ; Womens health</subject><ispartof>Cancer epidemiology, 2022-08, Vol.79, p.102195-102195, Article 102195</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><rights>2022. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-86842a92952672f51480a6829977f096b2d4b51ce9d28b6ec4531cb940f14e453</citedby><cites>FETCH-LOGICAL-c487t-86842a92952672f51480a6829977f096b2d4b51ce9d28b6ec4531cb940f14e453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2689040005?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27925,27926,45996,64386,64388,64390,72470</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35717688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bigman, Galya</creatorcontrib><creatorcontrib>Adebamowo, Sally N.</creatorcontrib><creatorcontrib>Yawe, King-David Terna</creatorcontrib><creatorcontrib>Yilkudi, Monday</creatorcontrib><creatorcontrib>Olaomi, Oluwole</creatorcontrib><creatorcontrib>Badejo, Olawale</creatorcontrib><creatorcontrib>Famooto, Ayo</creatorcontrib><creatorcontrib>Ezeome, Emmanuel</creatorcontrib><creatorcontrib>Salu, Iliya Karniliyus</creatorcontrib><creatorcontrib>Miner, Elijah</creatorcontrib><creatorcontrib>Anosike, Ikechukwu</creatorcontrib><creatorcontrib>Achusi, Benjamin</creatorcontrib><creatorcontrib>Adebamowo, Clement</creatorcontrib><title>Leisure-time physical activity is associated with reduced risks of breast cancer and triple negative breast cancer in Nigerian women</title><title>Cancer epidemiology</title><addtitle>Cancer Epidemiol</addtitle><description>Leisure-time physical activity(LTPA) is associated with a reduced risk of breast cancer, but this has less been investigated by cancer subtypes in Africans living in Sub-Saharan Africa(SSA). We examined the associations between LTPA and breast cancer including its subtypes in Nigerian women and explored the effect modification of body size on such associations.
The sample included 508 newly diagnosed primary invasive breast cancer cases and 892 controls from the Nigerian Integrative Epidemiology of Breast Cancer(NIBBLE) Study. Immunohistochemical(IHC) analysis was available for 294 cases. Total metabolic equivalents(METs) per hour/week of LTPA were calculated and divided by quartiles(Q1 <3.75, Q2:3.75–6.69, Q3:6.70–14.74, Q4:14.75 ≤). We applied logistic regressions to estimate the adjusted Odds Ratios(ORs) between LTPA and breast cancer and by its molecular subtypes and whether age-adjusted associations are modified by BMI.
The mean age(Mean±SD) of cases vs. controls(45.5 ± 11.1vs.40.1 ± 9.0) was higher, and the mean total METs hour/week was higher in controls vs. cases(11.9 ± 14.9vs.8.3 ± 11.1,p-value<0.001). Overall, 43.2%(N = 127/294) were classified as HRP, and 41.8%(N = 123/294) as TNBC. Women in the higher LTPA quartiles(Q3-Q4) vs. Q1 had lower odds of having breast cancer(ORQ4vs.Q1=0.51,95%CI:0.35–0.74) and TNBC(ORQ4vs.Q1=0.51, 95%CI:0.27–0.96), but not HRP(ORQ4vs.Q1=0.61,95%CI:0.34–1.09) after adjusting for age, age at first menarche, body size, breastfeeding, menopausal, parity, contraceptives, demographics, alcohol, smoking, and physical activity at home and work. Lastly, LTPA and its age-adjusted association with breast cancer was more pronounced in women with BMI< 30 vs. BMI 30 + .
LTPA may reduce the risk of breast cancer, especially TNBC, which is the more aggressive and prevalent molecular subtype of breast cancer in SSA.
•Breast cancer incidence in sub-Saharan Africa (SSA) is rising, and it is the most common cancer among Nigerian women.•Leisure-time physical activity (LTPA) is associated with a reduced risk of breast cancer and it varied by its subtypes.•LTPA and its age-adjusted association with breast cancer was more pronounced in non-obese vs. obese women.</description><subject>Age</subject><subject>Biopsy</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Breast cancer</subject><subject>Breast feeding</subject><subject>Breastfeeding & lactation</subject><subject>Cancer</subject><subject>Contraceptives</subject><subject>Demographics</subject><subject>Epidemiology</subject><subject>Exercise</subject><subject>Female</subject><subject>Growth factors</subject><subject>Health risks</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Invasiveness</subject><subject>Leisure</subject><subject>Leisure Activities</subject><subject>Leisure-time physical activity</subject><subject>Menarche</subject><subject>Menopause</subject><subject>Motor Activity</subject><subject>Nigeria</subject><subject>Nigeria - epidemiology</subject><subject>Nurses</subject><subject>Physical activity</subject><subject>Physical fitness</subject><subject>Pregnancy</subject><subject>Quartiles</subject><subject>Questionnaires</subject><subject>Risk management</subject><subject>Socioeconomic factors</subject><subject>Sub-Saharan Africa</subject><subject>Teaching hospitals</subject><subject>Triple Negative Breast Neoplasms - epidemiology</subject><subject>Triple-negative</subject><subject>Tumors</subject><subject>Womens health</subject><issn>1877-7821</issn><issn>1877-783X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kUtv1DAUhSMEoqXwC5CQJTZsMtgeJ7YXIKGKR6VR2YDEznKcm5k7JHGwnalmzw_Hw5RR6aIrv757fO49RfGS0QWjrH67XTg7wrTglPN8w5muHhXnTElZSrX88fi05-yseBbjltK6Zqx6WpwtK8lkrdR58XsFGOcAZcIByLTZR3S2J9Yl3GHaE4zExugd2gQtucG0IQHa2eVDwPgzEt-RJoCNiWQ3DgKxY0tSwKkHMsLaZh24R-BIrnENAe1IbvwA4_PiSWf7CC9u14vi-6eP3y6_lKuvn68uP6xKJ5RMpaqV4FZzXfFa8q5iQlFbK661lB3VdcNb0VTMgW65ampwoloy12hBOyYgHy6K90fdaW4GaB2MKdjeTAEHG_bGWzT_v4y4MWu_M1pTwanOAm9uBYL_NUNMZsDooO9zEH6OJvtSUoiK04y-vodu_RzG3F6mVNajlB4cLY-UCz7GAN3JDKPmkLLZmr8pm0PK5phyrnp1t49Tzb9YM_DuCECe5g4hmOgQ8vBbDOCSaT0--MEfoWq7Qg</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Bigman, Galya</creator><creator>Adebamowo, Sally N.</creator><creator>Yawe, King-David Terna</creator><creator>Yilkudi, Monday</creator><creator>Olaomi, Oluwole</creator><creator>Badejo, Olawale</creator><creator>Famooto, Ayo</creator><creator>Ezeome, Emmanuel</creator><creator>Salu, Iliya Karniliyus</creator><creator>Miner, Elijah</creator><creator>Anosike, Ikechukwu</creator><creator>Achusi, Benjamin</creator><creator>Adebamowo, Clement</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220801</creationdate><title>Leisure-time physical activity is associated with reduced risks of breast cancer and triple negative breast cancer in Nigerian women</title><author>Bigman, Galya ; Adebamowo, Sally N. ; Yawe, King-David Terna ; Yilkudi, Monday ; Olaomi, Oluwole ; Badejo, Olawale ; Famooto, Ayo ; Ezeome, Emmanuel ; Salu, Iliya Karniliyus ; Miner, Elijah ; Anosike, Ikechukwu ; Achusi, Benjamin ; Adebamowo, Clement</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-86842a92952672f51480a6829977f096b2d4b51ce9d28b6ec4531cb940f14e453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Biopsy</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Breast cancer</topic><topic>Breast feeding</topic><topic>Breastfeeding & lactation</topic><topic>Cancer</topic><topic>Contraceptives</topic><topic>Demographics</topic><topic>Epidemiology</topic><topic>Exercise</topic><topic>Female</topic><topic>Growth factors</topic><topic>Health risks</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Invasiveness</topic><topic>Leisure</topic><topic>Leisure Activities</topic><topic>Leisure-time physical activity</topic><topic>Menarche</topic><topic>Menopause</topic><topic>Motor Activity</topic><topic>Nigeria</topic><topic>Nigeria - epidemiology</topic><topic>Nurses</topic><topic>Physical activity</topic><topic>Physical fitness</topic><topic>Pregnancy</topic><topic>Quartiles</topic><topic>Questionnaires</topic><topic>Risk management</topic><topic>Socioeconomic factors</topic><topic>Sub-Saharan Africa</topic><topic>Teaching hospitals</topic><topic>Triple Negative Breast Neoplasms - epidemiology</topic><topic>Triple-negative</topic><topic>Tumors</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bigman, Galya</creatorcontrib><creatorcontrib>Adebamowo, Sally N.</creatorcontrib><creatorcontrib>Yawe, King-David Terna</creatorcontrib><creatorcontrib>Yilkudi, Monday</creatorcontrib><creatorcontrib>Olaomi, Oluwole</creatorcontrib><creatorcontrib>Badejo, Olawale</creatorcontrib><creatorcontrib>Famooto, Ayo</creatorcontrib><creatorcontrib>Ezeome, Emmanuel</creatorcontrib><creatorcontrib>Salu, Iliya Karniliyus</creatorcontrib><creatorcontrib>Miner, Elijah</creatorcontrib><creatorcontrib>Anosike, Ikechukwu</creatorcontrib><creatorcontrib>Achusi, Benjamin</creatorcontrib><creatorcontrib>Adebamowo, Clement</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bigman, Galya</au><au>Adebamowo, Sally N.</au><au>Yawe, King-David Terna</au><au>Yilkudi, Monday</au><au>Olaomi, Oluwole</au><au>Badejo, Olawale</au><au>Famooto, Ayo</au><au>Ezeome, Emmanuel</au><au>Salu, Iliya Karniliyus</au><au>Miner, Elijah</au><au>Anosike, Ikechukwu</au><au>Achusi, Benjamin</au><au>Adebamowo, Clement</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leisure-time physical activity is associated with reduced risks of breast cancer and triple negative breast cancer in Nigerian women</atitle><jtitle>Cancer epidemiology</jtitle><addtitle>Cancer Epidemiol</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>79</volume><spage>102195</spage><epage>102195</epage><pages>102195-102195</pages><artnum>102195</artnum><issn>1877-7821</issn><eissn>1877-783X</eissn><abstract>Leisure-time physical activity(LTPA) is associated with a reduced risk of breast cancer, but this has less been investigated by cancer subtypes in Africans living in Sub-Saharan Africa(SSA). We examined the associations between LTPA and breast cancer including its subtypes in Nigerian women and explored the effect modification of body size on such associations.
The sample included 508 newly diagnosed primary invasive breast cancer cases and 892 controls from the Nigerian Integrative Epidemiology of Breast Cancer(NIBBLE) Study. Immunohistochemical(IHC) analysis was available for 294 cases. Total metabolic equivalents(METs) per hour/week of LTPA were calculated and divided by quartiles(Q1 <3.75, Q2:3.75–6.69, Q3:6.70–14.74, Q4:14.75 ≤). We applied logistic regressions to estimate the adjusted Odds Ratios(ORs) between LTPA and breast cancer and by its molecular subtypes and whether age-adjusted associations are modified by BMI.
The mean age(Mean±SD) of cases vs. controls(45.5 ± 11.1vs.40.1 ± 9.0) was higher, and the mean total METs hour/week was higher in controls vs. cases(11.9 ± 14.9vs.8.3 ± 11.1,p-value<0.001). Overall, 43.2%(N = 127/294) were classified as HRP, and 41.8%(N = 123/294) as TNBC. Women in the higher LTPA quartiles(Q3-Q4) vs. Q1 had lower odds of having breast cancer(ORQ4vs.Q1=0.51,95%CI:0.35–0.74) and TNBC(ORQ4vs.Q1=0.51, 95%CI:0.27–0.96), but not HRP(ORQ4vs.Q1=0.61,95%CI:0.34–1.09) after adjusting for age, age at first menarche, body size, breastfeeding, menopausal, parity, contraceptives, demographics, alcohol, smoking, and physical activity at home and work. Lastly, LTPA and its age-adjusted association with breast cancer was more pronounced in women with BMI< 30 vs. BMI 30 + .
LTPA may reduce the risk of breast cancer, especially TNBC, which is the more aggressive and prevalent molecular subtype of breast cancer in SSA.
•Breast cancer incidence in sub-Saharan Africa (SSA) is rising, and it is the most common cancer among Nigerian women.•Leisure-time physical activity (LTPA) is associated with a reduced risk of breast cancer and it varied by its subtypes.•LTPA and its age-adjusted association with breast cancer was more pronounced in non-obese vs. obese women.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>35717688</pmid><doi>10.1016/j.canep.2022.102195</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1877-7821 |
| ispartof | Cancer epidemiology, 2022-08, Vol.79, p.102195-102195, Article 102195 |
| issn | 1877-7821 1877-783X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9904209 |
| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Age Biopsy Body mass index Body size Breast cancer Breast feeding Breastfeeding & lactation Cancer Contraceptives Demographics Epidemiology Exercise Female Growth factors Health risks Humans Insulin resistance Invasiveness Leisure Leisure Activities Leisure-time physical activity Menarche Menopause Motor Activity Nigeria Nigeria - epidemiology Nurses Physical activity Physical fitness Pregnancy Quartiles Questionnaires Risk management Socioeconomic factors Sub-Saharan Africa Teaching hospitals Triple Negative Breast Neoplasms - epidemiology Triple-negative Tumors Womens health |
| title | Leisure-time physical activity is associated with reduced risks of breast cancer and triple negative breast cancer in Nigerian women |
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