Choroid plexus perfusion and bulk cerebrospinal fluid flow across the adult lifespan
The choroid plexus (ChP) comprises a collection of modified ependymal cells that play an important role in the production of brain cerebrospinal fluid (CSF), and ChP perfusion aberrations have been implicated in a range of cerebrovascular and neurodegenerative disorders. To provide an exemplar for t...
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| Veröffentlicht in: | Journal of cerebral blood flow and metabolism 2023-02, Vol.43 (2), p.269-280 |
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| container_title | Journal of cerebral blood flow and metabolism |
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| creator | Eisma, Jarrod J McKnight, Colin D Hett, Kilian Elenberger, Jason Song, Alexander K Stark, Adam J Claassen, Daniel O Donahue, Manus J |
| description | The choroid plexus (ChP) comprises a collection of modified ependymal cells that play an important role in the production of brain cerebrospinal fluid (CSF), and ChP perfusion aberrations have been implicated in a range of cerebrovascular and neurodegenerative disorders. To provide an exemplar for the growing interest in ChP activity, we evaluated ChP perfusion and bulk CSF flow cross-sectionally across the healthy adult lifespan. Participants (n = 77; age range = 21–86 years) were scanned at 3T using T1-weighted, T2-weighted-FLAIR, perfusion-weighted pCASL, and phase contrast MRI to calculate ChP anatomy, perfusion, and aqueductal CSF flow, respectively. Regression models were applied to evaluate aging effects on ChP volume and ChP perfusion in the lateral ventricles, as well as CSF flow. ChP volume (mean ± std = 2.81 ± 1.1 cm3) increased (p |
| doi_str_mv | 10.1177/0271678X221129101 |
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To provide an exemplar for the growing interest in ChP activity, we evaluated ChP perfusion and bulk CSF flow cross-sectionally across the healthy adult lifespan. Participants (n = 77; age range = 21–86 years) were scanned at 3T using T1-weighted, T2-weighted-FLAIR, perfusion-weighted pCASL, and phase contrast MRI to calculate ChP anatomy, perfusion, and aqueductal CSF flow, respectively. Regression models were applied to evaluate aging effects on ChP volume and ChP perfusion in the lateral ventricles, as well as CSF flow. ChP volume (mean ± std = 2.81 ± 1.1 cm3) increased (p < 0.001), ChP perfusion (36.3 ± 8.6 mL/100 g/min) decreased (p = 0.0078), and ChP total blood flow (1.13 ± 0.34 mL/min) increased (p < 0.001) with age. Cranial-to-caudal net CSF flow (0.245 ± 0.20 mL/min) decreased, absolute CSF flow (4.86 ± 2.96 mL/min) increased, and CSF regurgitant fraction (0.87 ± 0.126) increased with age (all: p < 0.001). ChP perfusion was directly related to net cranial-to-caudal CSF flow through the aqueduct (p = 0.033). The implications of these findings are discussed in the context of the growing literature on CSF circulatory dysfunction in neurodegeneration and cerebrovascular disease.</description><identifier>ISSN: 0271-678X</identifier><identifier>EISSN: 1559-7016</identifier><identifier>DOI: 10.1177/0271678X221129101</identifier><identifier>PMID: 36200473</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Brain ; Cerebral Ventricles ; Cerebrospinal Fluid - physiology ; Choroid Plexus - diagnostic imaging ; Choroid Plexus - metabolism ; Humans ; Longevity ; Middle Aged ; Original ; Perfusion ; Young Adult</subject><ispartof>Journal of cerebral blood flow and metabolism, 2023-02, Vol.43 (2), p.269-280</ispartof><rights>The Author(s) 2022</rights><rights>The Author(s) 2022 2022 International Society for Cerebral Blood Flow and Metabolism</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-22fccceaa207f2828d0d8f75c41416084932dc75c105ef9f8bb27ff111bee90f3</citedby><cites>FETCH-LOGICAL-c438t-22fccceaa207f2828d0d8f75c41416084932dc75c105ef9f8bb27ff111bee90f3</cites><orcidid>0000-0002-2056-5469</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903224/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903224/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,21819,27924,27925,43621,43622,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36200473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eisma, Jarrod J</creatorcontrib><creatorcontrib>McKnight, Colin D</creatorcontrib><creatorcontrib>Hett, Kilian</creatorcontrib><creatorcontrib>Elenberger, Jason</creatorcontrib><creatorcontrib>Song, Alexander K</creatorcontrib><creatorcontrib>Stark, Adam J</creatorcontrib><creatorcontrib>Claassen, Daniel O</creatorcontrib><creatorcontrib>Donahue, Manus J</creatorcontrib><title>Choroid plexus perfusion and bulk cerebrospinal fluid flow across the adult lifespan</title><title>Journal of cerebral blood flow and metabolism</title><addtitle>J Cereb Blood Flow Metab</addtitle><description>The choroid plexus (ChP) comprises a collection of modified ependymal cells that play an important role in the production of brain cerebrospinal fluid (CSF), and ChP perfusion aberrations have been implicated in a range of cerebrovascular and neurodegenerative disorders. To provide an exemplar for the growing interest in ChP activity, we evaluated ChP perfusion and bulk CSF flow cross-sectionally across the healthy adult lifespan. Participants (n = 77; age range = 21–86 years) were scanned at 3T using T1-weighted, T2-weighted-FLAIR, perfusion-weighted pCASL, and phase contrast MRI to calculate ChP anatomy, perfusion, and aqueductal CSF flow, respectively. Regression models were applied to evaluate aging effects on ChP volume and ChP perfusion in the lateral ventricles, as well as CSF flow. ChP volume (mean ± std = 2.81 ± 1.1 cm3) increased (p < 0.001), ChP perfusion (36.3 ± 8.6 mL/100 g/min) decreased (p = 0.0078), and ChP total blood flow (1.13 ± 0.34 mL/min) increased (p < 0.001) with age. Cranial-to-caudal net CSF flow (0.245 ± 0.20 mL/min) decreased, absolute CSF flow (4.86 ± 2.96 mL/min) increased, and CSF regurgitant fraction (0.87 ± 0.126) increased with age (all: p < 0.001). ChP perfusion was directly related to net cranial-to-caudal CSF flow through the aqueduct (p = 0.033). The implications of these findings are discussed in the context of the growing literature on CSF circulatory dysfunction in neurodegeneration and cerebrovascular disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brain</subject><subject>Cerebral Ventricles</subject><subject>Cerebrospinal Fluid - physiology</subject><subject>Choroid Plexus - diagnostic imaging</subject><subject>Choroid Plexus - metabolism</subject><subject>Humans</subject><subject>Longevity</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Perfusion</subject><subject>Young Adult</subject><issn>0271-678X</issn><issn>1559-7016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtr3DAQx0VoSbZpP0AvRcdenM6M7ZV9CYSlLwjkkkJvQpZHWaday5GsPr59vd00NAR6GmbmN_95CfEa4QxRqXdACteq-UqESC0CHokV1nVbKMD1M7Ha54s9cCJepHQLAE1Z18fipFwTQKXKlbjebEMMQy8nzz9zkhNHl9MQRmnGXnbZf5OWI3cxpGkYjZfO54V2PvyQxi7RJOctS9NnP0s_OE6TGV-K5874xK_u7an48uH99eZTcXn18fPm4rKwVdnMBZGz1rIxBMpRQ00PfeNUbSuscA1N1ZbU28VHqNm1ruk6Us4hYsfcgitPxflBd8rdjnvL4xyN11Mcdib-0sEM-nFmHLb6JnzXbQslUbUIvL0XiOEuc5r1bkiWvTcjh5w0KaISK1KwoHhA_ywd2T20QdD7b-gn31hq3vw730PF3_MvwNkBSOaG9W3IcTlx-o_ib75IlJM</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Eisma, Jarrod J</creator><creator>McKnight, Colin D</creator><creator>Hett, Kilian</creator><creator>Elenberger, Jason</creator><creator>Song, Alexander K</creator><creator>Stark, Adam J</creator><creator>Claassen, Daniel O</creator><creator>Donahue, Manus J</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2056-5469</orcidid></search><sort><creationdate>20230201</creationdate><title>Choroid plexus perfusion and bulk cerebrospinal fluid flow across the adult lifespan</title><author>Eisma, Jarrod J ; McKnight, Colin D ; Hett, Kilian ; Elenberger, Jason ; Song, Alexander K ; Stark, Adam J ; Claassen, Daniel O ; Donahue, Manus J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-22fccceaa207f2828d0d8f75c41416084932dc75c105ef9f8bb27ff111bee90f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Brain</topic><topic>Cerebral Ventricles</topic><topic>Cerebrospinal Fluid - physiology</topic><topic>Choroid Plexus - diagnostic imaging</topic><topic>Choroid Plexus - metabolism</topic><topic>Humans</topic><topic>Longevity</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Perfusion</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eisma, Jarrod J</creatorcontrib><creatorcontrib>McKnight, Colin D</creatorcontrib><creatorcontrib>Hett, Kilian</creatorcontrib><creatorcontrib>Elenberger, Jason</creatorcontrib><creatorcontrib>Song, Alexander K</creatorcontrib><creatorcontrib>Stark, Adam J</creatorcontrib><creatorcontrib>Claassen, Daniel O</creatorcontrib><creatorcontrib>Donahue, Manus J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cerebral blood flow and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eisma, Jarrod J</au><au>McKnight, Colin D</au><au>Hett, Kilian</au><au>Elenberger, Jason</au><au>Song, Alexander K</au><au>Stark, Adam J</au><au>Claassen, Daniel O</au><au>Donahue, Manus J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Choroid plexus perfusion and bulk cerebrospinal fluid flow across the adult lifespan</atitle><jtitle>Journal of cerebral blood flow and metabolism</jtitle><addtitle>J Cereb Blood Flow Metab</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>43</volume><issue>2</issue><spage>269</spage><epage>280</epage><pages>269-280</pages><issn>0271-678X</issn><eissn>1559-7016</eissn><abstract>The choroid plexus (ChP) comprises a collection of modified ependymal cells that play an important role in the production of brain cerebrospinal fluid (CSF), and ChP perfusion aberrations have been implicated in a range of cerebrovascular and neurodegenerative disorders. To provide an exemplar for the growing interest in ChP activity, we evaluated ChP perfusion and bulk CSF flow cross-sectionally across the healthy adult lifespan. Participants (n = 77; age range = 21–86 years) were scanned at 3T using T1-weighted, T2-weighted-FLAIR, perfusion-weighted pCASL, and phase contrast MRI to calculate ChP anatomy, perfusion, and aqueductal CSF flow, respectively. Regression models were applied to evaluate aging effects on ChP volume and ChP perfusion in the lateral ventricles, as well as CSF flow. ChP volume (mean ± std = 2.81 ± 1.1 cm3) increased (p < 0.001), ChP perfusion (36.3 ± 8.6 mL/100 g/min) decreased (p = 0.0078), and ChP total blood flow (1.13 ± 0.34 mL/min) increased (p < 0.001) with age. Cranial-to-caudal net CSF flow (0.245 ± 0.20 mL/min) decreased, absolute CSF flow (4.86 ± 2.96 mL/min) increased, and CSF regurgitant fraction (0.87 ± 0.126) increased with age (all: p < 0.001). ChP perfusion was directly related to net cranial-to-caudal CSF flow through the aqueduct (p = 0.033). The implications of these findings are discussed in the context of the growing literature on CSF circulatory dysfunction in neurodegeneration and cerebrovascular disease.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>36200473</pmid><doi>10.1177/0271678X221129101</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-2056-5469</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Brain Cerebral Ventricles Cerebrospinal Fluid - physiology Choroid Plexus - diagnostic imaging Choroid Plexus - metabolism Humans Longevity Middle Aged Original Perfusion Young Adult |
| title | Choroid plexus perfusion and bulk cerebrospinal fluid flow across the adult lifespan |
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