A review of harmonization strategies for quantitative PET
PET can reveal in vivo biological processes at the molecular level. PET-derived quantitative values have been used as a surrogate marker for clinical decision-making in numerous clinical studies and trials. However, quantitative values in PET are variable depending on technical, biological, and phys...
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| Veröffentlicht in: | Annals of nuclear medicine 2023-02, Vol.37 (2), p.71-88 |
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| container_title | Annals of nuclear medicine |
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| creator | Akamatsu, Go Tsutsui, Yuji Daisaki, Hiromitsu Mitsumoto, Katsuhiko Baba, Shingo Sasaki, Masayuki |
| description | PET can reveal in vivo biological processes at the molecular level. PET-derived quantitative values have been used as a surrogate marker for clinical decision-making in numerous clinical studies and trials. However, quantitative values in PET are variable depending on technical, biological, and physical factors. The variability may have a significant impact on a study outcome. Appropriate scanner calibration and quality control, standardization of imaging protocols, and any necessary harmonization strategies are essential to make use of PET as a biomarker with low bias and variability. This review summarizes benefits, limitations, and remaining challenges for harmonization of quantitative PET, including whole-body PET in oncology, brain PET in neurology, PET/MR, and non-
18
F PET imaging. This review is expected to facilitate harmonization of quantitative PET and to promote the contribution of PET-derived biomarkers to research and development in medicine. |
| doi_str_mv | 10.1007/s12149-022-01820-x |
| format | Article |
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F PET imaging. This review is expected to facilitate harmonization of quantitative PET and to promote the contribution of PET-derived biomarkers to research and development in medicine.</description><subject>Biological activity</subject><subject>Biomarkers</subject><subject>Calibration</subject><subject>Clinical trials</subject><subject>Decision making</subject><subject>Head</subject><subject>Humans</subject><subject>Imaging</subject><subject>Invited Review</subject><subject>Invited Review Article</subject><subject>Magnetic resonance imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Nuclear Medicine</subject><subject>Phantoms, Imaging</subject><subject>Physical factors</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Positron-Emission Tomography - methods</subject><subject>Quality control</subject><subject>R&D</subject><subject>Radiology</subject><subject>Reference Standards</subject><subject>Research & development</subject><subject>Reviews</subject><subject>Standardization</subject><subject>Variability</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kTlPJDEQha0VCIbjD2ywaomEpKF82wkSQiwgIUEAseXutgejmTbY3cPx6_EyHAsBUQXvq1ev9BD6jWEPA8j9jAlmugZCasCKQP34C02wEqwWjNIVNAGNWS2xkutoI-dbAKK4ImtonQoBkgkxQfqwSm4R3EMVfXVj0zz24dkOIfZVHpId3DS4XPmYqvvR9kMYirZw1eXx1RZa9XaW3fbb3ETXf4-vjk7r84uTs6PD87rlgg010R33WHBOlaPEd13LBAPspfW68RzL1jbecw-soZ2WHe5ECck72TScYq_pJjpY-t6Nzdx1retLrpm5S2Fu05OJNpivSh9uzDQujNZAKCXFYPfNIMX70eXBzENu3WxmexfHbIgUWCtKpCrozjf0No6pL-8VSlLFQQEUiiypNsWck_MfYTCYf82YZTOmNGNemzGPZenP_298rLxXUQC6BHKR-qlLn7d_sH0BEOOaRQ</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Akamatsu, Go</creator><creator>Tsutsui, Yuji</creator><creator>Daisaki, Hiromitsu</creator><creator>Mitsumoto, Katsuhiko</creator><creator>Baba, Shingo</creator><creator>Sasaki, Masayuki</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9686-8901</orcidid></search><sort><creationdate>20230201</creationdate><title>A review of harmonization strategies for quantitative PET</title><author>Akamatsu, Go ; 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| subjects | Biological activity Biomarkers Calibration Clinical trials Decision making Head Humans Imaging Invited Review Invited Review Article Magnetic resonance imaging Medicine Medicine & Public Health Neuroimaging Neurology Nuclear Medicine Phantoms, Imaging Physical factors Positron emission Positron emission tomography Positron-Emission Tomography - methods Quality control R&D Radiology Reference Standards Research & development Reviews Standardization Variability |
| title | A review of harmonization strategies for quantitative PET |
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