Follicular pancreatitis: Case report and literature review
Follicular pancreatitis is a very rare type of focal chronic pancreatitis and is often mistaken for pancreatic neoplasms. It is histologically characterized by extensive lymphoid follicular formation with reactive germinal centers. A 50-year-old man was admitted to our hospital with 1-month history...
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| Veröffentlicht in: | Medicine (Baltimore) 2023-02, Vol.102 (5), p.e32837-e32837 |
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| creator | Lee, Wan-Sik Kim, Ki-Hyun Noh, Myung-Giun Joo, Young-Eun |
| description | Follicular pancreatitis is a very rare type of focal chronic pancreatitis and is often mistaken for pancreatic neoplasms. It is histologically characterized by extensive lymphoid follicular formation with reactive germinal centers.
A 50-year-old man was admitted to our hospital with 1-month history of epigastric pain. Contrast-enhanced computed tomography and magnetic resonance imaging revealed a 4.7 cm sized enhancing pancreatic head mass with anterior mesenteric soft tissue infiltration and superior mesenteric vein invasion. Endoscopic ultrasonography revealed an ill-defined hypoechoic mass in the head of the pancreas.
A laparoscopic surgical biopsy was performed. Hematoxylin-eosin staining showed the acini structure destruction within the pancreatic parenchyma and different-sized lymphoid follicles with reactive germinal centers around the duct. Immunohistochemical examination showed that cells were positive for the B-cell marker CD20, T-cell marker CD3, and slightly positive for IgG4. However, cells were negative for the B-cell marker Bcl-2. Follicular pancreatitis was confirmed based on the findings of histology and immunohistochemistry.
The patient was regularly followed without any specific treatment.
Follow-up computed tomography revealed no change in the lesion 1 year after diagnosis.
To the best of our knowledge, this is the first case of follicular pancreatitis in Korea. |
| doi_str_mv | 10.1097/MD.0000000000032837 |
| format | Article |
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A 50-year-old man was admitted to our hospital with 1-month history of epigastric pain. Contrast-enhanced computed tomography and magnetic resonance imaging revealed a 4.7 cm sized enhancing pancreatic head mass with anterior mesenteric soft tissue infiltration and superior mesenteric vein invasion. Endoscopic ultrasonography revealed an ill-defined hypoechoic mass in the head of the pancreas.
A laparoscopic surgical biopsy was performed. Hematoxylin-eosin staining showed the acini structure destruction within the pancreatic parenchyma and different-sized lymphoid follicles with reactive germinal centers around the duct. Immunohistochemical examination showed that cells were positive for the B-cell marker CD20, T-cell marker CD3, and slightly positive for IgG4. However, cells were negative for the B-cell marker Bcl-2. Follicular pancreatitis was confirmed based on the findings of histology and immunohistochemistry.
The patient was regularly followed without any specific treatment.
Follow-up computed tomography revealed no change in the lesion 1 year after diagnosis.
To the best of our knowledge, this is the first case of follicular pancreatitis in Korea.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000032837</identifier><identifier>PMID: 36749228</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Clinical Case Report ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Pancreas - pathology ; Pancreatic Neoplasms - pathology ; Pancreatitis, Chronic - pathology</subject><ispartof>Medicine (Baltimore), 2023-02, Vol.102 (5), p.e32837-e32837</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4508-731929b24a5d5b9ca1944dc56dae7783079450aa5d9b59e8b75e94f8503142943</citedby><cites>FETCH-LOGICAL-c4508-731929b24a5d5b9ca1944dc56dae7783079450aa5d9b59e8b75e94f8503142943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901974/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901974/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36749228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Wan-Sik</creatorcontrib><creatorcontrib>Kim, Ki-Hyun</creatorcontrib><creatorcontrib>Noh, Myung-Giun</creatorcontrib><creatorcontrib>Joo, Young-Eun</creatorcontrib><title>Follicular pancreatitis: Case report and literature review</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Follicular pancreatitis is a very rare type of focal chronic pancreatitis and is often mistaken for pancreatic neoplasms. It is histologically characterized by extensive lymphoid follicular formation with reactive germinal centers.
A 50-year-old man was admitted to our hospital with 1-month history of epigastric pain. Contrast-enhanced computed tomography and magnetic resonance imaging revealed a 4.7 cm sized enhancing pancreatic head mass with anterior mesenteric soft tissue infiltration and superior mesenteric vein invasion. Endoscopic ultrasonography revealed an ill-defined hypoechoic mass in the head of the pancreas.
A laparoscopic surgical biopsy was performed. Hematoxylin-eosin staining showed the acini structure destruction within the pancreatic parenchyma and different-sized lymphoid follicles with reactive germinal centers around the duct. Immunohistochemical examination showed that cells were positive for the B-cell marker CD20, T-cell marker CD3, and slightly positive for IgG4. However, cells were negative for the B-cell marker Bcl-2. Follicular pancreatitis was confirmed based on the findings of histology and immunohistochemistry.
The patient was regularly followed without any specific treatment.
Follow-up computed tomography revealed no change in the lesion 1 year after diagnosis.
To the best of our knowledge, this is the first case of follicular pancreatitis in Korea.</description><subject>Clinical Case Report</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreas - pathology</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatitis, Chronic - pathology</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtPwzAMxyMEYuPxCZBQj1wKzqtpOCCh8ZRAXOAcpa3HAlk7knYT356Ojacvluyf_7b_hBxQOKag1cn9xTH8BGc5VxtkSCXPUqkzsUmGAEymSisxIDsxvgBQrpjYJgOeKaEZy4fk9Krx3pWdtyGZ2boMaFvXuniajGzEJOCsCW1i6yrxrsVg2y4sq3OHiz2yNbY-4v4675Knq8vH0U1693B9Ozq_S0shIU8Vp5rpggkrK1no0lItRFXKrLKoVM5B6Z6zfVcXUmNeKIlajHMJnAqmBd8lZyvdWVdMsSqxboP1Zhbc1IZ301hn_nZqNzHPzdxoDbR_vhc4WguE5q3D2JqpiyV6b2tsumiYUoJleQZLlK_QMjQxBhx_r6Fglq6b-wvz3_V-6vD3hd8zXzb3gFgBi8b3LsZX3y0wmAla304-9aTSLGXAODDgkC5LOf8ApZuMaQ</recordid><startdate>20230203</startdate><enddate>20230203</enddate><creator>Lee, Wan-Sik</creator><creator>Kim, Ki-Hyun</creator><creator>Noh, Myung-Giun</creator><creator>Joo, Young-Eun</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230203</creationdate><title>Follicular pancreatitis: Case report and literature review</title><author>Lee, Wan-Sik ; Kim, Ki-Hyun ; Noh, Myung-Giun ; Joo, Young-Eun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4508-731929b24a5d5b9ca1944dc56dae7783079450aa5d9b59e8b75e94f8503142943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Clinical Case Report</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pancreas - pathology</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatitis, Chronic - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Wan-Sik</creatorcontrib><creatorcontrib>Kim, Ki-Hyun</creatorcontrib><creatorcontrib>Noh, Myung-Giun</creatorcontrib><creatorcontrib>Joo, Young-Eun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Wan-Sik</au><au>Kim, Ki-Hyun</au><au>Noh, Myung-Giun</au><au>Joo, Young-Eun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Follicular pancreatitis: Case report and literature review</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2023-02-03</date><risdate>2023</risdate><volume>102</volume><issue>5</issue><spage>e32837</spage><epage>e32837</epage><pages>e32837-e32837</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Follicular pancreatitis is a very rare type of focal chronic pancreatitis and is often mistaken for pancreatic neoplasms. It is histologically characterized by extensive lymphoid follicular formation with reactive germinal centers.
A 50-year-old man was admitted to our hospital with 1-month history of epigastric pain. Contrast-enhanced computed tomography and magnetic resonance imaging revealed a 4.7 cm sized enhancing pancreatic head mass with anterior mesenteric soft tissue infiltration and superior mesenteric vein invasion. Endoscopic ultrasonography revealed an ill-defined hypoechoic mass in the head of the pancreas.
A laparoscopic surgical biopsy was performed. Hematoxylin-eosin staining showed the acini structure destruction within the pancreatic parenchyma and different-sized lymphoid follicles with reactive germinal centers around the duct. Immunohistochemical examination showed that cells were positive for the B-cell marker CD20, T-cell marker CD3, and slightly positive for IgG4. However, cells were negative for the B-cell marker Bcl-2. Follicular pancreatitis was confirmed based on the findings of histology and immunohistochemistry.
The patient was regularly followed without any specific treatment.
Follow-up computed tomography revealed no change in the lesion 1 year after diagnosis.
To the best of our knowledge, this is the first case of follicular pancreatitis in Korea.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>36749228</pmid><doi>10.1097/MD.0000000000032837</doi><oa>free_for_read</oa></addata></record> |
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| source | Wolters Kluwer Open Health; MEDLINE; DOAJ Directory of Open Access Journals; IngentaConnect Free/Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Clinical Case Report Humans Magnetic Resonance Imaging Male Middle Aged Pancreas - pathology Pancreatic Neoplasms - pathology Pancreatitis, Chronic - pathology |
| title | Follicular pancreatitis: Case report and literature review |
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